A0B6L2 (APGM_METTP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	Mthe_0545

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_1000068384

Sequences

	Sequence		Length	Mass (Da)
	A0B6L2 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 94EAEA1F1AEA025E	FASTA	392	42,413
	10 20 30 40 50 60 MKYVVLLGDG MADWPMEALG GRTPLQVARK PNMDSIARIG RCGLARTVPE GMTPGSDVAN 70 80 90 100 110 120 LSIMGYDPRR YYTGRAPLEA AAMRIPLGEK EVAFRCNFVT VMDGIMDDYS AGHITSEEGA 130 140 150 160 170 180 EIAESLKKVI PGGRIYPGVS YRNIVVLKVC RDAVCTPPHD IMGKPISDHL PRGDDAHILI 190 200 210 220 230 240 DIMERARPLL EEHPVNRRRV SMGLKPANMI WLWGQGPAPS MPRFHEIYGL KGAVISAVDL 250 260 270 280 290 300 LKGLGVCAGW RVIDVPGATG TIDTNYAGKV RAALEALGSV DLVYLHIEAP DEAAHSGDVE 310 320 330 340 350 360 QKIRAIELFD ERVVGPMIHG LERSGEAWRV LLLPDHPTPI EIRTHSTDPV PFAIAGSGVC 370 380 390 VDSVDAFDEI SASEGGYGMI EGNDLIRLLI AG

References

[1]

"Complete sequence of Methanosaeta thermophila PT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK14336.1.
RefSeq	YP_842976.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B6L2.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B6L2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4463005.
GenomeReviews	Gene locus Mthe_0545 in contig CP000477_GR.
KEGG	mtp:Mthe_0545.
NMPDR	fig|349307.7.peg.562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04733.
HOGENOM	HBG463247.
OMA	ANSIWLW.
Enzyme and pathway databases
BioCyc	MTHE349307:MTHE_0545-MONOMER.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kinase_put. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit. TIGR02535. Hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METTP

Accession

Primary (citable) accession number: A0B6L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program