A0B6K7 (AROD_METTP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Mthe_0540

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325538
Sites
	Active site	124	1	Proton acceptor By similarity
	Active site	149	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0B6K7 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: F451815DA2DA4089	FASTA	226	24,335
	10 20 30 40 50 60 MCLRELDLNG LRIKTPAIVA SLGADAERVA SRAESEGADI IEVRLDLLAD PDVIRDIRST 70 80 90 100 110 120 VSLPLIATNR IASEGGSFRG SEERRISILR DASRFSDIID IELMAPGRDM LLKNISCPAL 130 140 150 160 170 180 ISYHDFSGVP DNLKSIIEDA MRAGADLVKI AVTPHSMQEA LAILRILLDV DCPLCIIGMG 190 200 210 220 AVGRHLRAVA PLYGSLLTYG YVTGPTAPGQ MSVRELDTAL RCLGAR

References

[1]

"Complete sequence of Methanosaeta thermophila PT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK14331.1.
RefSeq	YP_842971.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B6K7.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B6K7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4463000.
GenomeReviews	Gene locus Mthe_0540 in contig CP000477_GR.
KEGG	mtp:Mthe_0540.
NMPDR	fig|349307.7.peg.557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12575.
HOGENOM	HBG732926.
OMA	IESYHNF.
PhylomeDB	A0B6K7.
Enzyme and pathway databases
BioCyc	MTHE349307:MTHE_0540-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_METTP

Accession

Primary (citable) accession number: A0B6K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program