A0B6F9 (ARLY_METTP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Mthe_0492

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321461

Sequences

	Sequence		Length	Mass (Da)
	A0B6F9 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 067EAC9AE5A99622	FASTA	487	53,853
	10 20 30 40 50 60 MLLRGSRLGD ISGEVLDFIS SRDVDLWIAE ADVLVDMAHL LMLYERGLIP REDCARILTA 70 80 90 100 110 120 LKELLAEGFG VLGEGEDIHE AIEAYVIERV GPAGGRMHTA RSRNDEVATC IRIALREQML 130 140 150 160 170 180 GLMDELIQMI DALVRIADET RERIIPGYTH LQHAQPTTLA HHLLAHADAL IRDLERFEST 190 200 210 220 230 240 YERVNLSPLG AAAFASTGFD IDRYMTCELL GFSGLVENSM DAVSSRDFAL EVLSDTSILM 250 260 270 280 290 300 INLSRIAEEI ILWSTSEFGY VEVNDLFAST SSIMPQKKNP DTAELVRAKS GTAIGSLVGA 310 320 330 340 350 360 LSICKALPMS YNRDLQELTP HIWRGIGAAR SSLRVMRGCV STLRFDFERL ERSSTEGFTT 370 380 390 400 410 420 ATELADSMVR ITGIPFRTAH QIVGRLARLP GKPSLEDLDR AAMVVADLRL SQMGFTAEDL 430 440 450 460 470 480 ERALDPRTNI SMRSKPGGPA PEEVSRMLDA RKKYLESASS RLAEKRSKVD SAIRRLMEGV DRTVTAT

References

[1]

"Complete sequence of Methanosaeta thermophila PT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK14283.1.
RefSeq	YP_842923.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B6F9.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B6F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4463239.
GenomeReviews	Gene locus Mthe_0492 in contig CP000477_GR.
KEGG	mtp:Mthe_0492.
NMPDR	fig|349307.7.peg.506.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04975.
HOGENOM	HBG539632.
OMA	EDIHTVI.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	MTHE349307:MTHE_0492-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_METTP

Accession

Primary (citable) accession number: A0B6F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program