A0B6F6 (ARGC_METTP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Mthe_0489

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011017
Sites
	Active site	145	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0B6F6 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 6EAC8FB9E9AF10B4	FASTA	341	37,012
	10 20 30 40 50 60 MIDIGIVGGS GYTGGELLRL LSVHPSANVV CVTSRKLAGK PVTSVHQHLR GLLDLRFEAP 70 80 90 100 110 120 SPAEIAQRCD VVFTAVPHGT AMDWVPELLD NGAKVIDLSA DYRLPVDVFE KTYGIKHRAP 130 140 150 160 170 180 RDAVFGLPEL HPEVAGASLV GNPGCYPTGA TLAIAPLAKA GMVDRVVFDS KSGISGAGAE 190 200 210 220 230 240 PTETSHYPNL AENIRCYRVT NHRHVPEIKQ ELSRLQNDIR ISFTPHVIPA VRGILTTAHV 250 260 270 280 290 300 FVKDSFQDTI QDREFISKLY SDFYRNAKFV RLVEGVPMLG NVRCSNFCDI GFEIEKNSDR 310 320 330 340 IVVISAIDNL VKGASGQAIQ NMNLMMGLDE TAGLWFPGGA P

References

[1]

"Complete sequence of Methanosaeta thermophila PT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK14280.1.
RefSeq	YP_842920.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B6F6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B6F6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4463236.
GenomeReviews	Gene locus Mthe_0489 in contig CP000477_GR.
KEGG	mtp:Mthe_0489.
NMPDR	fig|349307.7.peg.503.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05044.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	A0B6F6.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MTHE349307:MTHE_0489-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_METTP

Accession

Primary (citable) accession number: A0B6F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program