A0B6C9 (TYPH_METTP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mthe_0462

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta › Methanosaeta thermophila

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314729

Sequences

	Sequence		Length	Mass (Da)
	A0B6C9 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 0C521FACEB78335E	FASTA	512	55,406
	10 20 30 40 50 60 MFEVVPFDIE IGQYKVMLNI ADARAMGLNP GDRVRVRTRG ASLTAILDVT GQMIGQGQVG 70 80 90 100 110 120 IFTEAFRDLK EAKSVEISPA PRPASISYIK MLMDRQKLSE DQIRSIVRDI VYNNLSEIEL 130 140 150 160 170 180 SAYITASYIH NLDPQETEWL TRAMIETGER IYFDKHPVVD KHSIGGVPGN KVSMLVVPIV 190 200 210 220 230 240 AASGLLIPKT SSRAITGAGG TADLMEVLAP VEFTADEIKE ITETVGGVIA WGGATNIAPA 250 260 270 280 290 300 DDRLIKAEYA LAIDPYSQML ASIMAKKGAV GADAVVVDMP TGPGTKLETP EKARVLAKDL 310 320 330 340 350 360 TDLGERLGIR VECAMTFGGS PVGRTVGPAL EVREALKMLE TGEGPNSLRE KSLALAGILL 370 380 390 400 410 420 EMGGVAARGE GYRAAEEILV SGKAHRKLME IVEAQGGDPK IRSEDIQIGE HQKQILSPTN 430 440 450 460 470 480 GYVVAFYNKR IIEIARAAGA PGDKRAGVII HKKMGEIVKK GEPLLTICSS TDWELECAVK 490 500 510 MCSMRDALEQ PPIVVEGMLL ERYPTERYPR TI

References

[1]

"Complete sequence of Methanosaeta thermophila PT." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK14253.1.
RefSeq	YP_842893.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B6C9.
ModBase	Search...
Protein-protein interaction databases
STRING	349307.Mthe_0462.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK14253; ABK14253; Mthe_0462.
GeneID	4462619.
KEGG	mtp:Mthe_0462.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MMET349307:GHKI-512-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METTP

Accession

Primary (citable) accession number: A0B6C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program