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A0B6C1

- DAPF_METTP

UniProt

A0B6C1 - DAPF_METTP

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei50 – 501SubstrateUniRule annotation
    Binding sitei68 – 681SubstrateUniRule annotation
    Active sitei77 – 771Proton donor/acceptorUniRule annotation
    Sitei161 – 1611Important for catalytic activityUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Sitei207 – 2071Important for catalytic activityUniRule annotation
    Active sitei217 – 2171Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciMMET349307:GHKI-462-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Mthe_0454
    OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
    Taxonomic identifieri349307 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000000674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Diaminopimelate epimerasePRO_1000011905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 217

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi349307.Mthe_0454.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B6C1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni77 – 793Substrate bindingUniRule annotation
    Regioni207 – 2082Substrate bindingUniRule annotation
    Regioni218 – 2192Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiLIVEPPY.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0B6C1-1 [UniParc]FASTAAdd to Basket

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    MNQLEFVKLH GNGNDFILID ELNGERIPED EKSEASRILC HRNFGIGGDG    50
    VLFLVPSERA DIGMRLFQPD GSEAEMCGNG IRCLAKHAWE SGYVGERFSV 100
    ETLAGVIPIQ VRRDRKGFWA RVEMGIPRFE RSEIPADGEG TFLKVPLHGF 150
    EVSAVNTGVP HAVIFVENLD IPVEQIAPKI RHSSCFPEGA NVNFVRLGNH 200
    LEVRTFERGV EAETLSCGTG SVAAAAVARR LGLVGETVEV MTKGGPLRIS 250
    FAGEKAFMEG PAVTVCRGVV SDEILQTLQ 279
    Length:279
    Mass (Da):30,386
    Last modified:November 28, 2006 - v1
    Checksum:iF1CF018283554695
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14245.1.
    RefSeqiWP_011695643.1. NC_008553.1.
    YP_842885.1. NC_008553.1.

    Genome annotation databases

    EnsemblBacteriaiABK14245; ABK14245; Mthe_0454.
    GeneIDi4462611.
    KEGGimtp:Mthe_0454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14245.1 .
    RefSeqi WP_011695643.1. NC_008553.1.
    YP_842885.1. NC_008553.1.

    3D structure databases

    ProteinModelPortali A0B6C1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349307.Mthe_0454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK14245 ; ABK14245 ; Mthe_0454 .
    GeneIDi 4462611.
    KEGGi mtp:Mthe_0454.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi LIVEPPY.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci MMET349307:GHKI-462-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6194 / PT.

    Entry informationi

    Entry nameiDAPF_METTP
    AccessioniPrimary (citable) accession number: A0B6C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3