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A0B6C1 (DAPF_METTP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7
Gene names
Name:dapF
Ordered Locus Names:Mthe_0454
OrganismMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]
Taxonomic identifier349307 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197

Subcellular location

Cytoplasm By similarity HAMAP MF_00197.

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlysine biosynthetic process via diaminopimelate

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondiaminopimelate epimerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Diaminopimelate epimerase HAMAP MF_00197
PRO_1000011905

Sites

Active site771 By similarity
Active site2171 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0B6C1 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: F1CF018283554695

FASTA27930,386
        10         20         30         40         50         60 
MNQLEFVKLH GNGNDFILID ELNGERIPED EKSEASRILC HRNFGIGGDG VLFLVPSERA 

        70         80         90        100        110        120 
DIGMRLFQPD GSEAEMCGNG IRCLAKHAWE SGYVGERFSV ETLAGVIPIQ VRRDRKGFWA 

       130        140        150        160        170        180 
RVEMGIPRFE RSEIPADGEG TFLKVPLHGF EVSAVNTGVP HAVIFVENLD IPVEQIAPKI 

       190        200        210        220        230        240 
RHSSCFPEGA NVNFVRLGNH LEVRTFERGV EAETLSCGTG SVAAAAVARR LGLVGETVEV 

       250        260        270 
MTKGGPLRIS FAGEKAFMEG PAVTVCRGVV SDEILQTLQ

« Hide

References

[1]"Complete sequence of Methanosaeta thermophila PT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Smith K.S., Ingram-Smith C., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6194 / PT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000477 Genomic DNA. Translation: ABK14245.1.
RefSeqYP_842885.1. NC_008553.1.

3D structure databases

ProteinModelPortalA0B6C1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0B6C1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4462611.
GenomeReviewsGene locus Mthe_0454 in contig CP000477_GR.
KEGGmtp:Mthe_0454.
NMPDRfig|349307.7.peg.468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG07445.
HOGENOMHBG399442.
OMANTGVPHV.
PhylomeDBA0B6C1.
ProtClustDBPRK00450.

Enzyme and pathway databases

BioCycMTHE349307:MTHE_0454-MONOMER.

Family and domain databases

HAMAPMF_00197. DAP_epimerase.
[Tree]
InterProIPR001653. DAP_epimerase_DapF.
[Graphical view]
KOK01778.
PfamPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsTIGR00652. DapF. 1 hit.
PROSITEPS01326. DAP_EPIMERASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPF_METTP
AccessionPrimary (citable) accession number: A0B6C1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 28, 2006
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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