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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Methanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei159 – 1591May be catalytically importantUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMMET349307:GHKI-363-MONOMER.
UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:Mthe_0355
OrganismiMethanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322GTP cyclohydrolase MptAPRO_0000289538Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349307.Mthe_0355.

Structurei

3D structure databases

ProteinModelPortaliA0B624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A0B624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLPDVQAC HPAYPINLTR VGVTGVKKLV KVERSGERPI VLISNFEVFV
60 70 80 90 100
DLPSSRKGAN LSRNTEAIDE VLEEEISRPV YEIEELCGKI ALRLLERHEY
110 120 130 140 150
ATRAEVKMKS EYIVKRQTPA TRVNCQEVVD IFAEAMATSG PDPHVKKIVG
160 170 180 190 200
AEVIGTTACP CAQEIVREQM RRDLLNLGLS EDAIEGFLKK VPVATHNQRG
210 220 230 240 250
RGSISIEVRD RKCVPIDRII RIIEESMSSK VYGLLKRPDE ALVVSRAHMN
260 270 280 290 300
PMFVEDCVRE MAQRVVATFV ELPDDAVVTL KQINEESIHR HNAFAERVAK
310 320
MGELRAELAA IHEMQPCGAS QM
Length:322
Mass (Da):36,117
Last modified:November 28, 2006 - v1
Checksum:i01C2A1F1319FD457
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK14148.1.

Genome annotation databases

EnsemblBacteriaiABK14148; ABK14148; Mthe_0355.
KEGGimtp:Mthe_0355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK14148.1.

3D structure databases

ProteinModelPortaliA0B624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349307.Mthe_0355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK14148; ABK14148; Mthe_0355.
KEGGimtp:Mthe_0355.

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Enzyme and pathway databases

UniPathwayiUPA00065.
BioCyciMMET349307:GHKI-363-MONOMER.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6194 / JCM 14653 / NBRC 101360 / PT.

Entry informationi

Entry nameiMPTA_METTP
AccessioniPrimary (citable) accession number: A0B624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.