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A0B5T8

- TF2B_METTP

UniProt

A0B5T8 - TF2B_METTP

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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411ZincUniRule annotation
Metal bindingi44 – 441ZincUniRule annotation
Metal bindingi60 – 601ZincUniRule annotation
Metal bindingi63 – 631ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri37 – 6832TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMET349307:GHKI-271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Mthe_0265
OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
ProteomesiUP000000674: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Transcription initiation factor IIBPRO_1000080114Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_0265.

Structurei

3D structure databases

ProteinModelPortaliA0B5T8.
SMRiA0B5T8. Positions 41-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 237841Add
BLAST
Repeati248 – 329822Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri37 – 6832TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B5T8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEIERIREI ERTEQEKIKE RIKLQREKEK EEELDKYTVE CPECGSRALV
60 70 80 90 100
RDYERAELVC SECGLVIDEN FIDQGPEWRA FDHDQRMKRS RVGAPMTYTI
110 120 130 140 150
HDKGLSTMID WRNRDSYGKT ISSKNRAQLY RLRKWQRRIR VSNATERNLA
160 170 180 190 200
FALSELDRMA SALGLSRNVR ETAAVIYRRA VEKNLIRGRS IEGVAAAALY
210 220 230 240 250
AACRQCNVPR TLDEIAEVSR VSRKEIGRTY RFVSRELSLK LMPTSPIDYI
260 270 280 290 300
PRFCSGLNLK GDVQAKGIEI LRQAAEKELT SGRGPTGVAA AAIYIASILC
310 320 330
NDRRTQREVA DVAGVTEVTI RNRYKELAEE LNIEIIL
Length:337
Mass (Da):38,703
Last modified:November 28, 2006 - v1
Checksum:iF1475DB2E705C788
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000477 Genomic DNA. Translation: ABK14062.1.
RefSeqiYP_842702.1. NC_008553.1.

Genome annotation databases

EnsemblBacteriaiABK14062; ABK14062; Mthe_0265.
GeneIDi4462795.
KEGGimtp:Mthe_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000477 Genomic DNA. Translation: ABK14062.1 .
RefSeqi YP_842702.1. NC_008553.1.

3D structure databases

ProteinModelPortali A0B5T8.
SMRi A0B5T8. Positions 41-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349307.Mthe_0265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK14062 ; ABK14062 ; Mthe_0265 .
GeneIDi 4462795.
KEGGi mtp:Mthe_0265.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MMET349307:GHKI-271-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6194 / PT.

Entry informationi

Entry nameiTF2B_METTP
AccessioniPrimary (citable) accession number: A0B5T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 28, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3