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A0B5T8 (TF2B_METTP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB

Short name=TFIIB
Gene names
Name:tfb
Ordered Locus Names:Mthe_0265
OrganismMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]
Taxonomic identifier349307 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity. HAMAP-Rule MF_00383

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00383

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Transcription initiation factor IIB HAMAP-Rule MF_00383
PRO_1000080114

Regions

Repeat154 – 237841 HAMAP-Rule MF_00383
Repeat248 – 329822 HAMAP-Rule MF_00383
Zinc finger37 – 6832TFIIB-type HAMAP-Rule MF_00383

Sites

Metal binding411Zinc By similarity
Metal binding441Zinc By similarity
Metal binding601Zinc By similarity
Metal binding631Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A0B5T8 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: F1475DB2E705C788

FASTA33738,703
        10         20         30         40         50         60 
MEEIERIREI ERTEQEKIKE RIKLQREKEK EEELDKYTVE CPECGSRALV RDYERAELVC 

        70         80         90        100        110        120 
SECGLVIDEN FIDQGPEWRA FDHDQRMKRS RVGAPMTYTI HDKGLSTMID WRNRDSYGKT 

       130        140        150        160        170        180 
ISSKNRAQLY RLRKWQRRIR VSNATERNLA FALSELDRMA SALGLSRNVR ETAAVIYRRA 

       190        200        210        220        230        240 
VEKNLIRGRS IEGVAAAALY AACRQCNVPR TLDEIAEVSR VSRKEIGRTY RFVSRELSLK 

       250        260        270        280        290        300 
LMPTSPIDYI PRFCSGLNLK GDVQAKGIEI LRQAAEKELT SGRGPTGVAA AAIYIASILC 

       310        320        330 
NDRRTQREVA DVAGVTEVTI RNRYKELAEE LNIEIIL 

« Hide

References

[1]"Complete sequence of Methanosaeta thermophila PT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Smith K.S., Ingram-Smith C., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6194 / PT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000477 Genomic DNA. Translation: ABK14062.1.
RefSeqYP_842702.1. NC_008553.1.

3D structure databases

ProteinModelPortalA0B5T8.
SMRA0B5T8. Positions 41-82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349307.Mthe_0265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK14062; ABK14062; Mthe_0265.
GeneID4462795.
KEGGmtp:Mthe_0265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108633.
KOK03124.
OMAWRAFDHD.

Enzyme and pathway databases

BioCycMMET349307:GHKI-271-MONOMER.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
HAMAPMF_00383. TF2B_arch.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTF2B_METTP
AccessionPrimary (citable) accession number: A0B5T8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 28, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families