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A0B5T8

- TF2B_METTP

UniProt

A0B5T8 - TF2B_METTP

Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi41 – 411ZincUniRule annotation
    Metal bindingi44 – 441ZincUniRule annotation
    Metal bindingi60 – 601ZincUniRule annotation
    Metal bindingi63 – 631ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri37 – 6832TFIIB-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMMET349307:GHKI-271-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIBUniRule annotation
    Short name:
    TFIIBUniRule annotation
    Gene namesi
    Name:tfbUniRule annotation
    Ordered Locus Names:Mthe_0265
    OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
    Taxonomic identifieri349307 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000000674: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Transcription initiation factor IIBPRO_1000080114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349307.Mthe_0265.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B5T8.
    SMRiA0B5T8. Positions 41-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati154 – 237841Add
    BLAST
    Repeati248 – 329822Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.UniRule annotation
    Contains 1 TFIIB-type zinc finger.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri37 – 6832TFIIB-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108633.
    KOiK03124.
    OMAiWRAFDHD.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    HAMAPiMF_00383. TF2B_arch.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0B5T8-1 [UniParc]FASTAAdd to Basket

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    MEEIERIREI ERTEQEKIKE RIKLQREKEK EEELDKYTVE CPECGSRALV    50
    RDYERAELVC SECGLVIDEN FIDQGPEWRA FDHDQRMKRS RVGAPMTYTI 100
    HDKGLSTMID WRNRDSYGKT ISSKNRAQLY RLRKWQRRIR VSNATERNLA 150
    FALSELDRMA SALGLSRNVR ETAAVIYRRA VEKNLIRGRS IEGVAAAALY 200
    AACRQCNVPR TLDEIAEVSR VSRKEIGRTY RFVSRELSLK LMPTSPIDYI 250
    PRFCSGLNLK GDVQAKGIEI LRQAAEKELT SGRGPTGVAA AAIYIASILC 300
    NDRRTQREVA DVAGVTEVTI RNRYKELAEE LNIEIIL 337
    Length:337
    Mass (Da):38,703
    Last modified:November 28, 2006 - v1
    Checksum:iF1475DB2E705C788
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14062.1.
    RefSeqiYP_842702.1. NC_008553.1.

    Genome annotation databases

    EnsemblBacteriaiABK14062; ABK14062; Mthe_0265.
    GeneIDi4462795.
    KEGGimtp:Mthe_0265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14062.1 .
    RefSeqi YP_842702.1. NC_008553.1.

    3D structure databases

    ProteinModelPortali A0B5T8.
    SMRi A0B5T8. Positions 41-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349307.Mthe_0265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK14062 ; ABK14062 ; Mthe_0265 .
    GeneIDi 4462795.
    KEGGi mtp:Mthe_0265.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108633.
    KOi K03124.
    OMAi WRAFDHD.

    Enzyme and pathway databases

    BioCyci MMET349307:GHKI-271-MONOMER.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    HAMAPi MF_00383. TF2B_arch.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6194 / PT.

    Entry informationi

    Entry nameiTF2B_METTP
    AccessioniPrimary (citable) accession number: A0B5T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3