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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mthe_0159
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987541 – 2212-phospho-L-lactate guanylyltransferaseAdd BLAST221

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349307.Mthe_0159.

Structurei

3D structure databases

ProteinModelPortaliA0B5I5.
SMRiA0B5I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiFRVDYHG.
OrthoDBiPOG093Z0CT7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0B5I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRPVHCVVP FKSSGCKTRL SSALSGEQRW QLAVAMLRDV LRTLRSIGMV
60 70 80 90 100
TVLARPGMRE DIIADLDATL RFSELELGDA LNGFIDENTA AGWPADILIV
110 120 130 140 150
MADLPLIREE DVLEMIRTPG GVVLAPGRGG GTNMILIRDS RFRTRYKGLS
160 170 180 190 200
FAKHKREAEE LGIEAGYCYS YRAGCDIDEP GDLIEILLHT NGESRALLER
210 220
FGLRILESDG RGRLDQTQSN E
Length:221
Mass (Da):24,488
Last modified:November 28, 2006 - v1
Checksum:i3F53F4E0E921ECAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK13959.1.

Genome annotation databases

EnsemblBacteriaiABK13959; ABK13959; Mthe_0159.
KEGGimtp:Mthe_0159.

Similar proteinsi

Entry informationi

Entry nameiCOFC_METTP
AccessioniPrimary (citable) accession number: A0B5I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 28, 2006
Last modified: January 31, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families