A0B578 (A0B578_METTP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Mthe_0050

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABK13852.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	189	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	242	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	114	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	116	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	124	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	227	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	199	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	211	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	268	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	307	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A0B578 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: EBBCD11F84AD41F8	FASTA	317	35,197
	10 20 30 40 50 60 MRRMRRLRRP GIREMVAETR ISVRDLIMPV FVDERIDQPV PISSMPGQMR QSLNSVAEEA 70 80 90 100 110 120 GRIEDLGIPA VILFGIPSRK DDLGSGAYDH DGVIQKAVRR IKESTDLVVI TDLCLCEYTS 130 140 150 160 170 180 HGHCGVIRGQ EIVNDETLPL LGRTAVSQAE SGADIVAPSG MMDHMVRAIR SALDDNGYTD 190 200 210 220 230 240 VAILSYAAKY ASYFYGPFRE AAESGFAFGD RRSYQMDPAN ANEALWEVQL DIEEGADMVM 250 260 270 280 290 300 VKPALPYLDI LRMVKERFSM PTAAYQVSGE YSMIMAAAER NWIDGDGVML ETLTSIKRAG 310 ADMIITYYAK DFAARFA

References

[1]

"Complete sequence of Methanosaeta thermophila PT." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK13852.1.
RefSeq	YP_842492.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B578.
SMR	A0B578. Positions 1-315.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B578.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4462741.
GenomeReviews	Gene locus Mthe_0050 in contig CP000477_GR.
KEGG	mtp:Mthe_0050.
NMPDR	fig|349307.7.peg.51.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	A0B578.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0B578_METTP

Accession

Primary (citable) accession number: A0B578

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)