A0B466 (ARGC_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Bcen2424_5709

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000137112
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0B466 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: CC8CF751C341BA62	FASTA	313	33,216
	10 20 30 40 50 60 MSFPTVFIDG DQGTTGLQIH ARLRDRTDVR LLTLPAAERK EAARRADALN ACDIAILCLP 70 80 90 100 110 120 DAAAREAVGF IRNPAVRVID ASSAHRTQPD WVYGFPEMAD GHAHEIAHAK RVTNPGCYPT 130 140 150 160 170 180 GAIGLLRPLL QAGLLPRDYP VSIHAVSGYS GGGRAAVDAF ESGDAAARAL PLQVYGLALA 190 200 210 220 230 240 HKHVPEIRQH AGLAHRPFFV PAYGAYRQGI VLTIPIELRL LPAGVTGERL HACLAHHYAD 250 260 270 280 290 300 ARHVDVMPLA DARAATHLDP QALNGTNDLR LGVFVNANGG QVLLSAVFDN LGKGASGAAV 310 QNLDLMLGAR HAA

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000459 Genomic DNA. Translation: ABK12442.1.
RefSeq	YP_839335.1. NC_008543.1.
3D structure databases
ProteinModelPortal	A0B466.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B466.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4452433.
GenomeReviews	Gene locus Bcen2424_5709 in contig CP000459_GR.
KEGG	bch:Bcen2424_5709.
PATRIC	19069057. VBIBurCen15205_5845.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	EIQQHAG.
ProtClustDB	PRK11863.
Enzyme and pathway databases
BioCyc	BCEN331272:BCEN2424_5709-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BURCH

Accession

Primary (citable) accession number: A0B466

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 28, 2006
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program