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A0B338

- GCH42_BURCH

UniProt

A0B338 - GCH42_BURCH

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Protein
GTP cyclohydrolase FolE2 2
Gene
folE2-2, Bcen2424_5331
Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBCEN331272:GHR7-5411-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 2 (EC:3.5.4.16)
Gene namesi
Name:folE2-2
Ordered Locus Names:Bcen2424_5331
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000000776: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316GTP cyclohydrolase FolE2 2UniRule annotation
PRO_0000289478Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331272.Bcen2424_5331.

Structurei

3D structure databases

ProteinModelPortaliA0B338.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B338-1 [UniParc]FASTAAdd to Basket

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MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR    50
RDVHARADVQ VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA 100
MVDSHRDCET RSARVRLRFD LLARRTALVT EGLAGWKAYP VRLDATLAGD 150
AFALRAQVTV VYSSTCPCSA ALSRHWIEQA FLTAFGHEAR VEPTAVAAWL 200
KRHAMAATPH SQRSEAVVSV ALPADGTTLG LLDLIDRVEQ ALGTPVQTAV 250
KRADEQAFAV LNGGNLMFVE DAARRVQAAL EDRHASPRVR VRHLESLHPH 300
DAVAWAAPLR EGADAC 316
Length:316
Mass (Da):34,188
Last modified:November 28, 2006 - v1
Checksum:i4152523B461CBCE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000459 Genomic DNA. Translation: ABK12064.1.
RefSeqiYP_838957.1. NC_008543.1.

Genome annotation databases

EnsemblBacteriaiABK12064; ABK12064; Bcen2424_5331.
GeneIDi4453728.
KEGGibch:Bcen2424_5331.
PATRICi19068309. VBIBurCen15205_5471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000459 Genomic DNA. Translation: ABK12064.1 .
RefSeqi YP_838957.1. NC_008543.1.

3D structure databases

ProteinModelPortali A0B338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331272.Bcen2424_5331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK12064 ; ABK12064 ; Bcen2424_5331 .
GeneIDi 4453728.
KEGGi bch:Bcen2424_5331.
PATRICi 19068309. VBIBurCen15205_5471.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BCEN331272:GHR7-5411-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI2424.

Entry informationi

Entry nameiGCH42_BURCH
AccessioniPrimary (citable) accession number: A0B338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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