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Protein

GTP cyclohydrolase FolE2 2

Gene

folE2-2

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathway:i7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 1 (folE2-1), GTP cyclohydrolase FolE2 2 (folE2-2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661May be catalytically importantUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBCEN331272:GHR7-5411-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-2UniRule annotation
Ordered Locus Names:Bcen2424_5331
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316GTP cyclohydrolase FolE2 2PRO_0000289478Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0B338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiPYSSTCP.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR
60 70 80 90 100
RDVHARADVQ VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA
110 120 130 140 150
MVDSHRDCET RSARVRLRFD LLARRTALVT EGLAGWKAYP VRLDATLAGD
160 170 180 190 200
AFALRAQVTV VYSSTCPCSA ALSRHWIEQA FLTAFGHEAR VEPTAVAAWL
210 220 230 240 250
KRHAMAATPH SQRSEAVVSV ALPADGTTLG LLDLIDRVEQ ALGTPVQTAV
260 270 280 290 300
KRADEQAFAV LNGGNLMFVE DAARRVQAAL EDRHASPRVR VRHLESLHPH
310
DAVAWAAPLR EGADAC
Length:316
Mass (Da):34,188
Last modified:November 28, 2006 - v1
Checksum:i4152523B461CBCE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000459 Genomic DNA. Translation: ABK12064.1.

Genome annotation databases

EnsemblBacteriaiABK12064; ABK12064; Bcen2424_5331.
KEGGibch:Bcen2424_5331.
PATRICi19068309. VBIBurCen15205_5471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000459 Genomic DNA. Translation: ABK12064.1.

3D structure databases

ProteinModelPortaliA0B338.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK12064; ABK12064; Bcen2424_5331.
KEGGibch:Bcen2424_5331.
PATRICi19068309. VBIBurCen15205_5471.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiPYSSTCP.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciBCEN331272:GHR7-5411-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI2424.

Entry informationi

Entry nameiGCH42_BURCH
AccessioniPrimary (citable) accession number: A0B338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.