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A0B2F5

- BETI_BURCH

UniProt

A0B2F5 - BETI_BURCH

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Protein

HTH-type transcriptional regulator BetI

Gene
betI, Bcen2424_5098
Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine By similarity.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
  2. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBCEN331272:GHR7-5173-MONOMER.
UniPathwayiUPA00529.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator BetI
Gene namesi
Name:betI
Ordered Locus Names:Bcen2424_5098
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000000776: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194HTH-type transcriptional regulator BetIUniRule annotationPRO_1000083553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331272.Bcen2424_5098.

Structurei

3D structure databases

ProteinModelPortaliA0B2F5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6861HTH tetR-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248227.
KOiK02167.
OMAiGHYPPET.
OrthoDBiEOG6FFS5N.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_00768. HTH_type_BetI.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B2F5-1 [UniParc]FASTAAdd to Basket

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MPKVGMREIR RAQLIDATLR SIDEAGLPGT TLASVAQRAN ISTGIVSHYF    50
GDKDGLLEAT MRHVLRDLWS ATTRRRVAAR KDPRSRLRAV VAANFDDTQV 100
SAPVMKTWLA FWSQSMHDPM LKRLQHVNTR RLHSNLCAEF AKALPLAKAR 150
EAASGLAALI DGLWLRGALA GGPIDTRAAL KLAHDYIDLL LASD 194
Length:194
Mass (Da):21,330
Last modified:November 28, 2006 - v1
Checksum:iBAF2C87D2E0D1B12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000459 Genomic DNA. Translation: ABK11831.1.
RefSeqiYP_838724.1. NC_008543.1.

Genome annotation databases

EnsemblBacteriaiABK11831; ABK11831; Bcen2424_5098.
GeneIDi4453674.
KEGGibch:Bcen2424_5098.
PATRICi19067828. VBIBurCen15205_5236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000459 Genomic DNA. Translation: ABK11831.1 .
RefSeqi YP_838724.1. NC_008543.1.

3D structure databases

ProteinModelPortali A0B2F5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331272.Bcen2424_5098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK11831 ; ABK11831 ; Bcen2424_5098 .
GeneIDi 4453674.
KEGGi bch:Bcen2424_5098.
PATRICi 19067828. VBIBurCen15205_5236.

Phylogenomic databases

eggNOGi COG1309.
HOGENOMi HOG000248227.
KOi K02167.
OMAi GHYPPET.
OrthoDBi EOG6FFS5N.

Enzyme and pathway databases

UniPathwayi UPA00529 .
BioCyci BCEN331272:GHR7-5173-MONOMER.

Family and domain databases

Gene3Di 1.10.357.10. 1 hit.
HAMAPi MF_00768. HTH_type_BetI.
InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsi TIGR03384. betaine_BetI. 1 hit.
PROSITEi PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI2424.

Entry informationi

Entry nameiBETI_BURCH
AccessioniPrimary (citable) accession number: A0B2F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 28, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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