A0B2F5 (BETI_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator BetI

Gene names

Name:	betI
Ordered Locus Names:	Bcen2424_5098

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Repressor involved in choline regulation of the bet genes By similarity. HAMAP-Rule MF_00768
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway [regulation]. HAMAP-Rule MF_00768
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	HTH-type transcriptional regulator BetI HAMAP-Rule MF_00768		PRO_1000083553
Regions
	Domain	8 – 68	61	HTH tetR-type
	DNA binding	31 – 50	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0B2F5 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: BAF2C87D2E0D1B12	FASTA	194	21,330
	10 20 30 40 50 60 MPKVGMREIR RAQLIDATLR SIDEAGLPGT TLASVAQRAN ISTGIVSHYF GDKDGLLEAT 70 80 90 100 110 120 MRHVLRDLWS ATTRRRVAAR KDPRSRLRAV VAANFDDTQV SAPVMKTWLA FWSQSMHDPM 130 140 150 160 170 180 LKRLQHVNTR RLHSNLCAEF AKALPLAKAR EAASGLAALI DGLWLRGALA GGPIDTRAAL 190 KLAHDYIDLL LASD

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000459 Genomic DNA. Translation: ABK11831.1.
RefSeq	YP_838724.1. NC_008543.1.
3D structure databases
ProteinModelPortal	A0B2F5.
ModBase	Search...
Protein-protein interaction databases
STRING	331272.Bcen2424_5098.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK11831; ABK11831; Bcen2424_5098.
GeneID	4453674.
KEGG	bch:Bcen2424_5098.
PATRIC	19067828. VBIBurCen15205_5236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1309.
HOGENOM	HOG000248227.
KO	K02167.
OMA	INHYFGG.
ProtClustDB	PRK00767.
Enzyme and pathway databases
BioCyc	BCEN331272:GHR7-3031-MONOMER.
UniPathway	UPA00529.
Family and domain databases
Gene3D	1.10.357.10. 1 hit.
HAMAP	MF_00768. HTH-type_BetI.
InterPro	IPR023772. DNA-bd_HTH_TetR-type_CS. IPR009057. Homeodomain-like. IPR001647. HTH_TetR. IPR015893. Tet_transcr_reg_TetR-like_C. IPR011075. Tet_transcr_reg_TetR-rel_C. IPR017757. Tscrpt_rep_BetI. [Graphical view]
Pfam	PF00440. TetR_N. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF48498. TetR_like_C. 1 hit.
TIGRFAMs	TIGR03384. betaine_BetI. 1 hit.
PROSITE	PS01081. HTH_TETR_1. 1 hit. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETI_BURCH

Accession

Primary (citable) accession number: A0B2F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program