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A0B2F5

- BETI_BURCH

UniProt

A0B2F5 - BETI_BURCH

Protein

HTH-type transcriptional regulator BetI

Gene

betI

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine By similarity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
    2. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBCEN331272:GHR7-5173-MONOMER.
    UniPathwayiUPA00529.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator BetIUniRule annotation
    Gene namesi
    Name:betIUniRule annotation
    Ordered Locus Names:Bcen2424_5098
    OrganismiBurkholderia cenocepacia (strain HI2424)
    Taxonomic identifieri331272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000000776: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194HTH-type transcriptional regulator BetIPRO_1000083553Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331272.Bcen2424_5098.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B2F5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 6861HTH tetR-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000248227.
    KOiK02167.
    OMAiGHYPPET.
    OrthoDBiEOG6FFS5N.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_00768. HTH_type_BetI.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR017757. Tscrpt_rep_BetI.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0B2F5-1 [UniParc]FASTAAdd to Basket

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    MPKVGMREIR RAQLIDATLR SIDEAGLPGT TLASVAQRAN ISTGIVSHYF    50
    GDKDGLLEAT MRHVLRDLWS ATTRRRVAAR KDPRSRLRAV VAANFDDTQV 100
    SAPVMKTWLA FWSQSMHDPM LKRLQHVNTR RLHSNLCAEF AKALPLAKAR 150
    EAASGLAALI DGLWLRGALA GGPIDTRAAL KLAHDYIDLL LASD 194
    Length:194
    Mass (Da):21,330
    Last modified:November 28, 2006 - v1
    Checksum:iBAF2C87D2E0D1B12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000459 Genomic DNA. Translation: ABK11831.1.
    RefSeqiYP_838724.1. NC_008543.1.

    Genome annotation databases

    EnsemblBacteriaiABK11831; ABK11831; Bcen2424_5098.
    GeneIDi4453674.
    KEGGibch:Bcen2424_5098.
    PATRICi19067828. VBIBurCen15205_5236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000459 Genomic DNA. Translation: ABK11831.1 .
    RefSeqi YP_838724.1. NC_008543.1.

    3D structure databases

    ProteinModelPortali A0B2F5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331272.Bcen2424_5098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK11831 ; ABK11831 ; Bcen2424_5098 .
    GeneIDi 4453674.
    KEGGi bch:Bcen2424_5098.
    PATRICi 19067828. VBIBurCen15205_5236.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000248227.
    KOi K02167.
    OMAi GHYPPET.
    OrthoDBi EOG6FFS5N.

    Enzyme and pathway databases

    UniPathwayi UPA00529 .
    BioCyci BCEN331272:GHR7-5173-MONOMER.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_00768. HTH_type_BetI.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR017757. Tscrpt_rep_BetI.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    TIGRFAMsi TIGR03384. betaine_BetI. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI2424.

    Entry informationi

    Entry nameiBETI_BURCH
    AccessioniPrimary (citable) accession number: A0B2F5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3