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A0B2E2 (A0B2E2_BURCH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 2 HAMAP MF_00051
Short name=SHMT 2 HAMAP MF_00051
Short name=Serine methylase 2 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA2 HAMAP MF_00051
Ordered Locus Names:Bcen2424_5085
OrganismBurkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP] EMBL ABK11818.1
Taxonomic identifier331272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2571N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
A0B2E2 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: 745A20E27833176D

FASTA44747,965
        10         20         30         40         50         60 
MGNPGTAGLE LRLQPFILRH GRTMSNTQPF FSQPLAERDA PVRSAILKEL ERQQSQVELI 

        70         80         90        100        110        120 
ASENIVSRAV LEAQGSVLTN KYAEGYPGKR YYGGCEFADE VEALAIDRVK QIFNAGYANV 

       130        140        150        160        170        180 
QPHSGAQANG SVMLALAKPG DTVLGMSLDA GGHLTHGAKP ALSGKWFNAV QYGVNRDTLR 

       190        200        210        220        230        240 
IDYDQVEALA HEHKPNLIIA GFSAYPRALD FARFRAIADS VGAKLMVDMA HIAGVIAAGR 

       250        260        270        280        290        300 
HANPVEHAHV VTSTTHKTLR GPRGGFVLTN DEDIAKKINS AVFPGLQGGP LMHVIAGKAV 

       310        320        330        340        350        360 
AFGEVLHADF KTYIDNVLAN AQALGEVLKA GGVDLVTGGT DNHLLLVDLR PKGLKGAPVE 

       370        380        390        400        410        420 
QALERAGITC NKNGIPFDTE KPTVTSGIRL GTPAGTTRGF GVAEFREVGR LILEVFDALR 

       430        440 
ANPEGDPATE QRVRREIFAL CERFPIY

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000459 Genomic DNA. Translation: ABK11818.1.
RefSeqYP_838711.2. NC_008543.1.

3D structure databases

ProteinModelPortalA0B2E2.
SMRA0B2E2. Positions 34-442.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0B2E2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4452969.
GenomeReviewsGene locus Bcen2424_5085 in contig CP000459_GR.
KEGGbch:Bcen2424_5085.
PATRIC19067798. VBIBurCen15205_5221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAIFNAGYA.
ProtClustDBPRK13034.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0B2E2_BURCH
AccessionPrimary (citable) accession number: A0B2E2
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info