A0AZQ0 (HYPRE_BURCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyproline epimerase
EC=5.1.1.8

Alternative name(s):
Hydroxyproline-2-epimerase
Short name=HyPRE

Gene names

Ordered Locus Names:

Bcen2424_4140

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases By similarity.
Catalytic activity	Trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the proline racemase family. 4-hydroxyproline epimerase subfamily.
Sequence caution	The sequence ABK10876.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	4-hydroxyproline epimerase activity Inferred from electronic annotation. Source: EC proline racemase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	4-hydroxyproline epimerase		PRO_0000354033
Sites
	Active site	88	1	Proton acceptor By similarity
	Active site	236	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0AZQ0 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 8A5DDDFE72E5C963	FASTA	310	32,684
	10 20 30 40 50 60 MKRIQIIDSH TGGEPTRLVV SGFPSLGRGT MAERRDVLAR EHDRYRTACI LEPRGSDVMV 70 80 90 100 110 120 GALLCDPVAP DAAAGVIFFN NSGYLGMCGH GTIGVVRTLH HMGRIEPGVH RIETPVGTVE 130 140 150 160 170 180 ATLHDDLSVS VRNVPAYRHA QGVVLDVPGY GPVKGDIAWG GNWFFLISDH GQRVAGDNVA 190 200 210 220 230 240 ALTAYASAVR EGLERAGITG ANGGEIDHIE LFADDPEHDS RSFVLCPGLA YDRSPCGTGT 250 260 270 280 290 300 SAKLACLAAD GKLAPGVVWR QASVIGSVFH ASYELADGGI VPTIRGSAHL SAEATLLIDE 310 DDPFGWGIGS

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI2424.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000459 Genomic DNA. Translation: ABK10876.1. Different initiation.
RefSeq	YP_837769.1. NC_008543.1.
3D structure databases
ProteinModelPortal	A0AZQ0.
ModBase	Search...
Protein-protein interaction databases
STRING	331272.Bcen2424_4140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK10876; ABK10876; Bcen2424_4140.
GeneID	4453008.
KEGG	bch:Bcen2424_4140.
PATRIC	19065821. VBIBurCen15205_4237.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3938.
HOGENOM	HOG000084335.
KO	K12658.
ProtClustDB	PRK13970.
Enzyme and pathway databases
BioCyc	BCEN331272:GHR7-1990-MONOMER.
Family and domain databases
InterPro	IPR008794. Pro_racemase. [Graphical view]
Pfam	PF05544. Pro_racemase. 1 hit. [Graphical view]
PIRSF	PIRSF029792. Pro_racemase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HYPRE_BURCH

Accession

Primary (citable) accession number: A0AZQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program