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A0AZ18 (A0AZ18_BURCH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109
EC=1.1.1.44 PIRNR PIRNR000109
Gene names
Ordered Locus Names:Bcen2424_3907
OrganismBurkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP] EMBL ABK10644.1
Taxonomic identifier331272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2621Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2891Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A0AZ18 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: 0BDC58CA96722195

FASTA47050,944
        10         20         30         40         50         60 
MGKQAIGVIG LAVMGRNLAL NIESRGYAVS VFNRSREKTD ELIAEFPGRN LVPTYTLEEF 

        70         80         90        100        110        120 
VASLETPRRI LMMVKAGEAT DATIASLKPL LEKGDVLIDG GNTHFTDTIR RNQELAQSGL 

       130        140        150        160        170        180 
HFIGTGVSGG EEGALRGPSI MPGGQRDAYD LVEPILKQIA AKAPSDGEPC VAYMGPDGAG 

       190        200        210        220        230        240 
HYVKMVHNGI EYGDMQLIAE SYSVLKDVAG LTNDELGAVY TEWNQGELDS YLIEITSKIF 

       250        260        270        280        290        300 
GKKDEETGKH LVDVILDRAA QKGTGKWTSQ NALDLGVPLP LITESVFARV LSSLKTERVA 

       310        320        330        340        350        360 
ASKILSGPAA APFDGDRAAF VEAVRRALYL SKVISYAQGF AQLRTASEEY GWNLDLGTIA 

       370        380        390        400        410        420 
KIFRAGCIIR ARFLQKITDA YAKDPALANL LLDPYFKDIA ANYQTALRDV VVAAVKAGVP 

       430        440        450        460        470 
VPAFASAVAY FDSYRSERLP ANLVQAQRDF FGAHTFERTD KPGSFHANWS

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000459 Genomic DNA. Translation: ABK10644.1.
RefSeqYP_837537.1. NC_008543.1.

3D structure databases

ProteinModelPortalA0AZ18.
SMRA0AZ18. Positions 7-469.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0AZ18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4452260.
GenomeReviewsGene locus Bcen2424_3907 in contig CP000459_GR.
KEGGbch:Bcen2424_3907.
PATRIC19065336. VBIBurCen15205_3995.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMAMEHNEMA.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0AZ18_BURCH
AccessionPrimary (citable) accession number: A0AZ18
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info