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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 1 (folE2-1), GTP cyclohydrolase FolE2 2 (folE2-2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-1UniRule annotation
Ordered Locus Names:Bcen2424_3880
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002894771 – 269GTP cyclohydrolase FolE2 1Add BLAST269

Structurei

3D structure databases

ProteinModelPortaliA0AYZ1
SMRiA0AYZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A0AYZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVCT ESGDVQPTVG
60 70 80 90 100
VWNLDVRLPA DQKGTHMSRF VALLEENRAP LTVERFRAML ASMLVKLEAE
110 120 130 140 150
AGRIEVTFPY FVNKTAPVSG VQSLLDYEVT LAGESRNGDT RLFLKVLVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DLPVEALIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLDADERVV AYVLEAENFE
260
SIHNHSAYAL IERDKRQAA
Length:269
Mass (Da):30,143
Last modified:November 28, 2006 - v1
Checksum:i39A9ACB49B04B529
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000459 Genomic DNA Translation: ABK10617.1
RefSeqiWP_011548148.1, NC_008543.1

Genome annotation databases

EnsemblBacteriaiABK10617; ABK10617; Bcen2424_3880
KEGGibch:Bcen2424_3880

Similar proteinsi

Entry informationi

Entry nameiGCH41_BURCH
AccessioniPrimary (citable) accession number: A0AYZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health