Reviewed, UniProtKB/Swiss-Prot A0AYX8 (KHSE_BURCH)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bcen2424_3867

Organism

Burkholderia cenocepacia (strain HI2424) [Complete proteome] [HAMAP]

Taxonomic identifier

331272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Homoserine kinase HAMAP MF_00301		PRO_0000300785

Sequences

	Sequence		Length	Mass (Da)
	A0AYX8-1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: CA5E3D0BD59F3755	FASTA	332	37,186
	10 20 30 40 50 60 MAVFTAVSDS DLAQWMRHYE LGDVLAFRGI PSGIENSNFF LTTTRGEYVL TIFEKLTAQQ 70 80 90 100 110 120 LPFYLDLMRH LAAHGVPVPD PIPRDDGALF GELHGKPAAI VTKLDGAAEL APGVEHCIEV 130 140 150 160 170 180 GQMLARLHLA GRDYPRNQPN LRSLPWWQEN VPAIVPFITD AQRALLEGEL AHQAGFFASD 190 200 210 220 230 240 DYAALPAGPC HCDLFRDNVL FAHAAPGTGH DVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGVLDV ARADALLRAY QTVRPFTAEE RRHWSDMLRA GAYRFWVSRL YDFYLPRAAE 310 320 330 MLKPHDPGHF ERILRERIAH TPALPEIQTA CN

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000459 Genomic DNA. Translation: ABK10604.1.
RefSeq	YP_837497.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0AYX8.
Genome annotation databases
GeneID	4452048.
GenomeReviews	Gene locus Bcen2424_3867 in contig CP000459_GR.
KEGG	bch:Bcen2424_3867.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	A0AYX8.
OMA	ADLFRDN.
Family and domain databases
HAMAP	MF_00301. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURCH

Accession

Primary (citable) accession number: A0AYX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 28, 2006
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)