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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Burkholderia cenocepacia (strain HI2424)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciBCEN331272:GHR7-3241-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:Bcen2424_3168
OrganismiBurkholderia cenocepacia (strain HI2424)
Taxonomic identifieri331272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Probable malate:quinone oxidoreductasePRO_0000325490Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0AWY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A0AWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGSAVIKT LRVILSALAL CVATSSAHAA DTKKVDVLLV GGGIMSSTLG
60 70 80 90 100
VWLHELQPNW SMTMVERLDG VALESSNGWN NAGTGHSALA ELNYTPEKAD
110 120 130 140 150
GKVDISKAIE INESFQISRQ FWAWQVKQGV LKNPHSFINS TPHMSFVWGD
160 170 180 190 200
DNVRFLKKRY EALQASPLFR GMQYSEDYDQ IKQWVPLMME GRDRNQKVAA
210 220 230 240 250
TWTPIGTDVN FGEITRQFVG YLKTQPNFTL SLSSEVREIT RNADGTWHVS
260 270 280 290 300
WVKLHSDEPP QSVDAKFVFI GAGGGALHLL QASGIPEAKD YGAFPVGGSF
310 320 330 340 350
LVTDNPEVVK QHLAKAYGKA SVGSPPMSVP HLDTRIIDGK KIILFGPFAT
360 370 380 390 400
FSTKFLKNGS YFDLAKSTNL HNVAPMMRVG VDEFPLVQYL AGQLMLTDDD
410 420 430 440 450
RFNALKEYFP NAKKEDWRLW QAGQRVQIIK RDPVKGGVLK LGTEIVASQD
460 470 480 490 500
GSIAGLLGAS PGASTAAPIM LNLMQKVFKD KVATPEWQQK IRQIVPSYGT
510 520 530 540 550
KLNDSPAKVV EEWTYTSDVL QLSPPPKIDL GAPSQATGNA PARPAKASAD

MAL
Length:553
Mass (Da):60,584
Last modified:March 18, 2008 - v2
Checksum:i113DCA21FC45E048
GO

Sequence cautioni

The sequence ABK09915.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000459 Genomic DNA. Translation: ABK09915.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABK09915; ABK09915; Bcen2424_3168.
KEGGibch:Bcen2424_3168.
PATRICi19063850. VBIBurCen15205_3256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000459 Genomic DNA. Translation: ABK09915.1. Different initiation.

3D structure databases

ProteinModelPortaliA0AWY9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK09915; ABK09915; Bcen2424_3168.
KEGGibch:Bcen2424_3168.
PATRICi19063850. VBIBurCen15205_3256.

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciBCEN331272:GHR7-3241-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia HI2424."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., LiPuma J.J., Gonzalez C.F., Konstantinidis K., Tiedje J.M., Richardson P.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI2424.

Entry informationi

Entry nameiMQO_BURCH
AccessioniPrimary (citable) accession number: A0AWY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.