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A0AVT1

- UBA6_HUMAN

UniProt

A0AVT1 - UBA6_HUMAN

Protein

Ubiquitin-like modifier-activating enzyme 6

Gene

UBA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.3 Publications

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei625 – 6251Glycyl thioester intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi470 – 50031ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FAT10 activating enzyme activity Source: UniProtKB
    3. ligase activity Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 6
    Short name:
    Ubiquitin-activating enzyme 6
    Alternative name(s):
    Monocyte protein 4
    Short name:
    MOP-4
    Ubiquitin-activating enzyme E1-like protein 2
    Short name:
    E1-L2
    Gene namesi
    Name:UBA6
    Synonyms:MOP4, UBE1L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25581. UBA6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. cytosol Source: RefGenome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi625 – 6251C → A or S: Impairs ubiquitin activation. 2 Publications

    Organism-specific databases

    PharmGKBiPA162407690.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10521052Ubiquitin-like modifier-activating enzyme 6PRO_0000277797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei544 – 5441N6-acetyllysine1 Publication
    Modified residuei729 – 7291N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiA0AVT1.
    PaxDbiA0AVT1.
    PRIDEiA0AVT1.

    PTM databases

    PhosphoSiteiA0AVT1.

    Expressioni

    Tissue specificityi

    Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.2 Publications

    Gene expression databases

    ArrayExpressiA0AVT1.
    BgeeiA0AVT1.
    GenevestigatoriA0AVT1.

    Organism-specific databases

    HPAiHPA037001.
    HPA044870.

    Interactioni

    Subunit structurei

    Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).

    Protein-protein interaction databases

    BioGridi120529. 40 interactions.
    DIPiDIP-57633N.
    IntActiA0AVT1. 1 interaction.
    MINTiMINT-1195700.

    Structurei

    3D structure databases

    ProteinModelPortaliA0AVT1.
    SMRiA0AVT1. Positions 38-1019.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-activating E1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0476.
    HOVERGENiHBG054199.
    InParanoidiA0AVT1.
    KOiK10699.
    OMAiFSPLCQW.
    OrthoDBiEOG74R1PV.
    PhylomeDBiA0AVT1.
    TreeFamiTF300586.

    Family and domain databases

    Gene3Di1.10.3240.10. 2 hits.
    3.40.50.720. 4 hits.
    InterProiIPR009036. Molybdenum_cofac_synth_MoeB.
    IPR016040. NAD(P)-bd_dom.
    IPR000594. ThiF_NAD_FAD-bd.
    IPR018965. Ub-activating_enz_e1_C.
    IPR023280. Ub-like_act_enz_cat_cys_dom.
    IPR000127. UBact_repeat.
    IPR019572. Ubiquitin-activating_enzyme.
    IPR018075. UBQ-activ_enz_E1.
    IPR000011. UBQ/SUMO-activ_enz_E1-like.
    [Graphical view]
    PfamiPF00899. ThiF. 2 hits.
    PF09358. UBA_e1_C. 1 hit.
    PF10585. UBA_e1_thiolCys. 1 hit.
    PF02134. UBACT. 1 hit.
    [Graphical view]
    PRINTSiPR01849. UBIQUITINACT.
    SMARTiSM00985. UBA_e1_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF69572. SSF69572. 2 hits.
    TIGRFAMsiTIGR01408. Ube1. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Named isoforms=3.

    Isoform 1 (identifier: A0AVT1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV     50
    LGDTAMQKMA KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD 100
    LGTNFFLSED DVVNKRNRAE AVLKHIAELN PYVHVTSSSV PFNETTDLSF 150
    LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP IKFISADVHG IWSRLFCDFG 200
    DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE TGQFLTFREI 250
    NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE 300
    SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD 350
    SEELLKLATS ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ 400
    EVLKAVTGKF SPLCQWLYLE AADIVESLGK PECEEFLPRG DRYDALRACI 450
    GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA LLGVGTSKEK GMITVTDPDL 500
    IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA HLNKVCPTTE 550
    TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT 600
    EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS 650
    HKPSLFNKFW QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV 700
    ELARLKFEKY FNHKALQLLH CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN 750
    EPLHLSFLQN AAKLYATVYC IPFAEEDLSA DALLNILSEV KIQEFKPSNK 800
    VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS DLQMAVLSFE 850
    KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT 900
    VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI 950
    SFTIWDRWTV HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG 1000
    HAKRLKLTMH KLVKPTTEKK YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD 1050
    TD 1052
    Length:1,052
    Mass (Da):117,970
    Last modified:November 28, 2006 - v1
    Checksum:i9F9C70EABA750A71
    GO
    Isoform 2 (identifier: A0AVT1-2) [UniParc]FASTAAdd to Basket

    Also known as: nUBE1L

    The sequence of this isoform differs from the canonical sequence as follows:
         1-474: Missing.

    Show »
    Length:578
    Mass (Da):65,757
    Checksum:i33FDBFF4EA8AADF0
    GO
    Isoform 3 (identifier: A0AVT1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         369-389: PDVNADIVHWLSWTAQGFLSP → VTIEIYGCPNICLLIHKCSVY
         390-1052: Missing.

    Show »
    Length:389
    Mass (Da):43,216
    Checksum:iE4534BE50710EF6C
    GO
    Isoform 4 (identifier: A0AVT1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         321-340: APLEIHTAMLALDQFQEKYS → VNKHFAGLREAAESEMRISE
         341-1052: Missing.

    Show »
    Length:340
    Mass (Da):37,693
    Checksum:iB73DEE549B7E7143
    GO

    Sequence cautioni

    The sequence BAA91824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141E → K in CAD89908. (PubMed:17974005)Curated
    Sequence conflicti140 – 1401V → A in CAD89908. (PubMed:17974005)Curated
    Sequence conflicti197 – 1971C → Y in BAC04463. (PubMed:14702039)Curated
    Sequence conflicti234 – 2341N → D in CAD89959. (PubMed:17974005)Curated
    Sequence conflicti297 – 2971V → A in BAC04463. (PubMed:14702039)Curated
    Sequence conflicti645 – 6451F → V in AAQ63403. (PubMed:15202508)Curated
    Sequence conflicti803 – 8031Q → H in BAA91824. (PubMed:14702039)Curated
    Sequence conflicti821 – 8211E → G in CAD89959. (PubMed:17974005)Curated
    Sequence conflicti868 – 8681L → P in CAD89908. (PubMed:17974005)Curated
    Sequence conflicti905 – 9051V → G in AAQ63403. (PubMed:15202508)Curated
    Sequence conflicti909 – 9091M → K in CAD89959. (PubMed:17974005)Curated
    Sequence conflicti920 – 9201A → V in BAB19785. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241A → T.3 Publications
    Corresponds to variant rs10010188 [ dbSNP | Ensembl ].
    VAR_030594

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 474474Missing in isoform 2. 1 PublicationVSP_023083Add
    BLAST
    Alternative sequencei321 – 34020APLEI…QEKYS → VNKHFAGLREAAESEMRISE in isoform 4. 1 PublicationVSP_023084Add
    BLAST
    Alternative sequencei341 – 1052712Missing in isoform 4. 1 PublicationVSP_023085Add
    BLAST
    Alternative sequencei369 – 38921PDVNA…GFLSP → VTIEIYGCPNICLLIHKCSV Y in isoform 3. 1 PublicationVSP_023086Add
    BLAST
    Alternative sequencei390 – 1052663Missing in isoform 3. 1 PublicationVSP_023087Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359880 mRNA. Translation: AAQ63403.1.
    EF623993 mRNA. Translation: ABR25253.1.
    AB014773 mRNA. Translation: BAB19785.1.
    AK001670 mRNA. Translation: BAA91824.1. Different initiation.
    AK094969 mRNA. Translation: BAC04463.1.
    AK314371 mRNA. Translation: BAG37000.1.
    AL832015 mRNA. Translation: CAD89908.1.
    AL832458 mRNA. Translation: CAD89959.1.
    AC079880 Genomic DNA. No translation available.
    AC096720 Genomic DNA. Translation: AAY40999.1.
    BC031637 mRNA. Translation: AAH31637.1.
    BC126484 mRNA. Translation: AAI26485.1.
    BC126486 mRNA. Translation: AAI26487.1.
    CCDSiCCDS3516.1. [A0AVT1-1]
    RefSeqiNP_060697.4. NM_018227.5. [A0AVT1-1]
    UniGeneiHs.212774.

    Genome annotation databases

    EnsembliENST00000322244; ENSP00000313454; ENSG00000033178. [A0AVT1-1]
    ENST00000420827; ENSP00000399234; ENSG00000033178. [A0AVT1-3]
    GeneIDi55236.
    KEGGihsa:55236.
    UCSCiuc003hdg.4. human. [A0AVT1-1]
    uc003hdi.3. human. [A0AVT1-3]
    uc003hdj.2. human. [A0AVT1-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359880 mRNA. Translation: AAQ63403.1 .
    EF623993 mRNA. Translation: ABR25253.1 .
    AB014773 mRNA. Translation: BAB19785.1 .
    AK001670 mRNA. Translation: BAA91824.1 . Different initiation.
    AK094969 mRNA. Translation: BAC04463.1 .
    AK314371 mRNA. Translation: BAG37000.1 .
    AL832015 mRNA. Translation: CAD89908.1 .
    AL832458 mRNA. Translation: CAD89959.1 .
    AC079880 Genomic DNA. No translation available.
    AC096720 Genomic DNA. Translation: AAY40999.1 .
    BC031637 mRNA. Translation: AAH31637.1 .
    BC126484 mRNA. Translation: AAI26485.1 .
    BC126486 mRNA. Translation: AAI26487.1 .
    CCDSi CCDS3516.1. [A0AVT1-1 ]
    RefSeqi NP_060697.4. NM_018227.5. [A0AVT1-1 ]
    UniGenei Hs.212774.

    3D structure databases

    ProteinModelPortali A0AVT1.
    SMRi A0AVT1. Positions 38-1019.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120529. 40 interactions.
    DIPi DIP-57633N.
    IntActi A0AVT1. 1 interaction.
    MINTi MINT-1195700.

    Chemistry

    ChEMBLi CHEMBL2321622.

    PTM databases

    PhosphoSitei A0AVT1.

    Proteomic databases

    MaxQBi A0AVT1.
    PaxDbi A0AVT1.
    PRIDEi A0AVT1.

    Protocols and materials databases

    DNASUi 55236.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322244 ; ENSP00000313454 ; ENSG00000033178 . [A0AVT1-1 ]
    ENST00000420827 ; ENSP00000399234 ; ENSG00000033178 . [A0AVT1-3 ]
    GeneIDi 55236.
    KEGGi hsa:55236.
    UCSCi uc003hdg.4. human. [A0AVT1-1 ]
    uc003hdi.3. human. [A0AVT1-3 ]
    uc003hdj.2. human. [A0AVT1-4 ]

    Organism-specific databases

    CTDi 55236.
    GeneCardsi GC04M068481.
    H-InvDB HIX0031574.
    HIX0120163.
    HGNCi HGNC:25581. UBA6.
    HPAi HPA037001.
    HPA044870.
    MIMi 611361. gene.
    neXtProti NX_A0AVT1.
    PharmGKBi PA162407690.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0476.
    HOVERGENi HBG054199.
    InParanoidi A0AVT1.
    KOi K10699.
    OMAi FSPLCQW.
    OrthoDBi EOG74R1PV.
    PhylomeDBi A0AVT1.
    TreeFami TF300586.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    ChiTaRSi UBA6. human.
    GeneWikii UBE1L2.
    GenomeRNAii 55236.
    NextBioi 59255.
    PROi A0AVT1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A0AVT1.
    Bgeei A0AVT1.
    Genevestigatori A0AVT1.

    Family and domain databases

    Gene3Di 1.10.3240.10. 2 hits.
    3.40.50.720. 4 hits.
    InterProi IPR009036. Molybdenum_cofac_synth_MoeB.
    IPR016040. NAD(P)-bd_dom.
    IPR000594. ThiF_NAD_FAD-bd.
    IPR018965. Ub-activating_enz_e1_C.
    IPR023280. Ub-like_act_enz_cat_cys_dom.
    IPR000127. UBact_repeat.
    IPR019572. Ubiquitin-activating_enzyme.
    IPR018075. UBQ-activ_enz_E1.
    IPR000011. UBQ/SUMO-activ_enz_E1-like.
    [Graphical view ]
    Pfami PF00899. ThiF. 2 hits.
    PF09358. UBA_e1_C. 1 hit.
    PF10585. UBA_e1_thiolCys. 1 hit.
    PF02134. UBACT. 1 hit.
    [Graphical view ]
    PRINTSi PR01849. UBIQUITINACT.
    SMARTi SM00985. UBA_e1_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69572. SSF69572. 2 hits.
    TIGRFAMsi TIGR01408. Ube1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characteristics of a novel E1 like gene nUBE1L in human testis."
      Zhu H., Zhou Z.-M., Huo R., Huang X.-Y., Lu L., Lin M., Wang L.-R., Zhou Y.-D., Li J.-M., Sha J.-H.
      Acta Biochim. Biophys. Sin. 36:227-234(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
    2. "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging."
      Jin J., Li X., Gygi S.P., Harper J.W.
      Nature 447:1135-1138(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-224, FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-625.
    3. "Molecular and biological characterization of a new ubiquitin-activating enzyme E1 like protein, MOP-4 which is highly expressed in human monocytes."
      Takayama K., Fujii Y., Ukai Y., Yoshimoto M.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT THR-224.
      Tissue: Hippocampus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-224.
      Tissue: Skeletal muscle.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.
    8. "E1-L2 activates both ubiquitin and FAT10."
      Chiu Y.-H., Sun Q., Chen Z.J.
      Mol. Cell 27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH UBD, THIOESTER FORMATION, MUTAGENESIS OF CYS-625.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBA6_HUMAN
    AccessioniPrimary (citable) accession number: A0AVT1
    Secondary accession number(s): A6N8M7
    , B2RAV3, Q4W5K0, Q6UV21, Q86T78, Q86TC7, Q8N5T3, Q8N9E4, Q9H3T7, Q9NVC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3