A0AVT1 (UBA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like modifier-activating enzyme 6
Short name=Ubiquitin-activating enzyme 6

Alternative name(s):
Monocyte protein 4
Short name=MOP-4
Ubiquitin-activating enzyme E1-like protein 2
Short name=E1-L2

Gene names

Name:	UBA6
Synonyms:	MOP4, UBE1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1052 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Ref.1 Ref.2 Ref.8
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).
Tissue specificity	Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. Ref.1 Ref.2
Sequence similarities	Belongs to the ubiquitin-activating E1 family.
Sequence caution	The sequence BAA91824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from mutant phenotype Ref.8. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW FAT10 activating enzyme activity Inferred from mutant phenotype Ref.8. Source: UniProtKB ligase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Named isoforms=3.

Isoform 1 (identifier: A0AVT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0AVT1-2)

Also known as: nUBE1L;

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.

Isoform 3 (identifier: A0AVT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     369-389: PDVNADIVHWLSWTAQGFLSP → VTIEIYGCPNICLLIHKCSVY
     390-1052: Missing.

Isoform 4 (identifier: A0AVT1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     321-340: APLEIHTAMLALDQFQEKYS → VNKHFAGLREAAESEMRISE
     341-1052: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1052	1052	Ubiquitin-like modifier-activating enzyme 6		PRO_0000277797
Regions
	Nucleotide binding	470 – 500	31	ATP By similarity
Sites
	Active site	625	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	544	1	N6-acetyllysine Ref.9
Natural variations
	Alternative sequence	1 – 474	474	Missing in isoform 2.		VSP_023083
	Alternative sequence	321 – 340	20	APLEI…QEKYS → VNKHFAGLREAAESEMRISE in isoform 4.		VSP_023084
	Alternative sequence	341 – 1052	712	Missing in isoform 4.		VSP_023085
	Alternative sequence	369 – 389	21	PDVNA…GFLSP → VTIEIYGCPNICLLIHKCSV Y in isoform 3.		VSP_023086
	Alternative sequence	390 – 1052	663	Missing in isoform 3.		VSP_023087
	Natural variant	224	1	A → T. Ref.2 Ref.4 Ref.5 Corresponds to variant rs10010188 [ dbSNP | Ensembl ].		VAR_030594
Experimental info
	Mutagenesis	625	1	C → A or S: Impairs ubiquitin activation. Ref.2 Ref.8
	Sequence conflict	14	1	E → K in CAD89908. Ref.5
	Sequence conflict	140	1	V → A in CAD89908. Ref.5
	Sequence conflict	197	1	C → Y in BAC04463. Ref.4
	Sequence conflict	234	1	N → D in CAD89959. Ref.5
	Sequence conflict	297	1	V → A in BAC04463. Ref.4
	Sequence conflict	645	1	F → V in AAQ63403. Ref.1
	Sequence conflict	803	1	Q → H in BAA91824. Ref.4
	Sequence conflict	821	1	E → G in CAD89959. Ref.5
	Sequence conflict	868	1	L → P in CAD89908. Ref.5
	Sequence conflict	905	1	V → G in AAQ63403. Ref.1
	Sequence conflict	909	1	M → K in CAD89959. Ref.5
	Sequence conflict	920	1	A → V in BAB19785. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 9F9C70EABA750A71	FASTA	1,052	117,970
	10 20 30 40 50 60 MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA 70 80 90 100 110 120 KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE 130 140 150 160 170 180 AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP 190 200 210 220 230 240 IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE 250 260 270 280 290 300 TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE 310 320 330 340 350 360 SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS 370 380 390 400 410 420 ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE 430 440 450 460 470 480 AADIVESLGK PECEEFLPRG DRYDALRACI GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA 490 500 510 520 530 540 LLGVGTSKEK GMITVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA 550 560 570 580 590 600 HLNKVCPTTE TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT 610 620 630 640 650 660 EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW 670 680 690 700 710 720 QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH 730 740 750 760 770 780 CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQN AAKLYATVYC IPFAEEDLSA 790 800 810 820 830 840 DALLNILSEV KIQEFKPSNK VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS 850 860 870 880 890 900 DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT 910 920 930 940 950 960 VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI SFTIWDRWTV 970 980 990 1000 1010 1020 HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPTTEKK 1030 1040 1050 YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD TD
	Isoform 2 (nUBE1L) [UniParc]. Checksum: 33FDBFF4EA8AADF0	FASTA	578	65,757
	10 20 30 40 50 60 MLKNFALLGV GTSKEKGMIT VTDPDLIEKS NLNRQFLFRP HHIQKPKSYT AADATLKINS 70 80 90 100 110 120 QIKIDAHLNK VCPTTETIYN DEFYTKQDVI ITALDNVEAR RYVDSRCLAN LRPLLDSGTM 130 140 150 160 170 180 GTKGHTEVIV PHLTESYNSH RDPPEEEIPF CTLKSFPAAI EHTIQWARDK FESSFSHKPS 190 200 210 220 230 240 LFNKFWQTYS SAEEVLQKIQ SGHSLEGCFQ VIKLLSRRPR NWSQCVELAR LKFEKYFNHK 250 260 270 280 290 300 ALQLLHCFPL DIRLKDGSLF WQSPKRPPSP IKFDLNEPLH LSFLQNAAKL YATVYCIPFA 310 320 330 340 350 360 EEDLSADALL NILSEVKIQE FKPSNKVVQT DETARKPDHV PISSEDERNA IFQLEKAILS 370 380 390 400 410 420 NEATKSDLQM AVLSFEKDDD HNGHIDFITA ASNLRAKMYS IEPADRFKTK RIAGKIIPAI 430 440 450 460 470 480 ATTTATVSGL VALEMIKVTG GYPFEAYKNC FLNLAIPIVV FTETTEVRKT KIRNGISFTI 490 500 510 520 530 540 WDRWTVHGKE DFTLLDFINA VKEKYGIEPT MVVQGVKMLY VPVMPGHAKR LKLTMHKLVK 550 560 570 PTTEKKYVDL TVSFAPDIDG DEDLPGPPVR YYFSHDTD
	Isoform 3 [UniParc]. Checksum: E4534BE50710EF6C	FASTA	389	43,216
	10 20 30 40 50 60 MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA 70 80 90 100 110 120 KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE 130 140 150 160 170 180 AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP 190 200 210 220 230 240 IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE 250 260 270 280 290 300 TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE 310 320 330 340 350 360 SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS 370 380 ISETLEEKVT IEIYGCPNIC LLIHKCSVY
	Isoform 4 [UniParc]. Checksum: B73DEE549B7E7143	FASTA	340	37,693
	10 20 30 40 50 60 MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA 70 80 90 100 110 120 KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE 130 140 150 160 170 180 AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP 190 200 210 220 230 240 IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE 250 260 270 280 290 300 TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE 310 320 330 340 SLERQLKHPK CLIVDFSNPE VNKHFAGLRE AAESEMRISE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characteristics of a novel E1 like gene nUBE1L in human testis." Zhu H., Zhou Z.-M., Huo R., Huang X.-Y., Lu L., Lin M., Wang L.-R., Zhou Y.-D., Li J.-M., Sha J.-H. Acta Biochim. Biophys. Sin. 36:227-234(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
[2]	"Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging." Jin J., Li X., Gygi S.P., Harper J.W. Nature 447:1135-1138(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-224, FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-625.
[3]	"Molecular and biological characterization of a new ubiquitin-activating enzyme E1 like protein, MOP-4 which is highly expressed in human monocytes." Takayama K., Fujii Y., Ukai Y., Yoshimoto M. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Blood.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT THR-224. Tissue: Hippocampus.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-224. Tissue: Skeletal muscle.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[8]	"E1-L2 activates both ubiquitin and FAT10." Chiu Y.-H., Sun Q., Chen Z.J. Mol. Cell 27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH UBD, THIOESTER FORMATION, MUTAGENESIS OF CYS-625.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-544, MASS SPECTROMETRY.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY359880 mRNA. Translation: AAQ63403.1. EF623993 mRNA. Translation: ABR25253.1. AB014773 mRNA. Translation: BAB19785.1. AK001670 mRNA. Translation: BAA91824.1. Different initiation. AK094969 mRNA. Translation: BAC04463.1. AK314371 mRNA. Translation: BAG37000.1. AL832015 mRNA. Translation: CAD89908.1. AL832458 mRNA. Translation: CAD89959.1. AC079880 Genomic DNA. No translation available. AC096720 Genomic DNA. Translation: AAY40999.1. BC031637 mRNA. Translation: AAH31637.1. BC126484 mRNA. Translation: AAI26485.1. BC126486 mRNA. Translation: AAI26487.1.
IPI	IPI00023647. IPI00827491. IPI00827864. IPI00828006.
RefSeq	NP_060697.4. NM_018227.5.
UniGene	Hs.212774.
3D structure databases
ProteinModelPortal	A0AVT1.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1195700.
PTM databases
PhosphoSite	A0AVT1.
Proteomic databases
PaxDb	A0AVT1.
PRIDE	A0AVT1.
Protocols and materials databases
DNASU	55236.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322244; ENSP00000313454; ENSG00000033178. ENST00000420827; ENSP00000399234; ENSG00000033178.
GeneID	55236.
KEGG	hsa:55236.
UCSC	uc003hdg.4. human. uc003hdi.3. human. uc003hdj.2. human.
Organism-specific databases
CTD	55236.
GeneCards	GC04M068481.
H-InvDB	HIX0031574. HIX0120163.
HGNC	HGNC:25581. UBA6.
HPA	HPA037001.
MIM	611361. gene.
neXtProt	NX_A0AVT1.
PharmGKB	PA162407690.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0476.
HOVERGEN	HBG054199.
InParanoid	A0AVT1.
KO	K10699.
OMA	SRRPRNW.
OrthoDB	EOG4NKBTS.
PhylomeDB	A0AVT1.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	A0AVT1.
Bgee	A0AVT1.
Genevestigator	A0AVT1.
Family and domain databases
Gene3D	1.10.3240.10. 2 hits. 3.40.50.720. 4 hits.
InterPro	IPR009036. Molybdenum_cofac_synth_MoeB. IPR016040. NAD(P)-bd_dom. IPR000594. ThiF_NAD_FAD-bd. IPR018965. Ub-activating_enz_e1_C. IPR023280. Ub-like_act_enz_cat_cys_dom. IPR000127. UBact_repeat. IPR019572. Ubiquitin-activating_enzyme. IPR018075. UBQ-activ_enz_E1. IPR000011. UBQ/SUMO-activ_enz_E1-like. [Graphical view]
Pfam	PF00899. ThiF. 2 hits. PF09358. UBA_e1_C. 1 hit. PF10585. UBA_e1_thiolCys. 1 hit. PF02134. UBACT. 1 hit. [Graphical view]
PRINTS	PR01849. UBIQUITINACT.
SMART	SM00985. UBA_e1_C. 1 hit. [Graphical view]
SUPFAM	SSF69572. MoeB. 2 hits.
TIGRFAMs	TIGR01408. Ube1. 1 hit.
PROSITE	PS00536. UBIQUITIN_ACTIVAT_1. False negative. PS00865. UBIQUITIN_ACTIVAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	UBA6. human.
GenomeRNAi	55236.
NextBio	59255.
SOURCE	Search...

Entry information

Entry name

UBA6_HUMAN

Accession

Primary (citable) accession number: A0AVT1
Secondary accession number(s): A6N8M7 , B2RAV3, Q4W5K0, Q6UV21, Q86T78, Q86TC7, Q8N5T3, Q8N9E4, Q9H3T7, Q9NVC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.