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A0AVF1

- TTC26_HUMAN

UniProt

A0AVF1 - TTC26_HUMAN

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Protein

Tetratricopeptide repeat protein 26

Gene

TTC26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a critical role in ciliogenesis and normal cilia function.By similarity

GO - Biological processi

  1. cilium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 26
Short name:
TPR repeat protein 26
Gene namesi
Name:TTC26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21882. TTC26.

Subcellular locationi

Cell projectioncilium By similarity
Note: Localizes at the base to the ciliary transition zone.By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. ciliary basal body Source: Ensembl
  3. intraciliary transport particle B Source: Ensembl
  4. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Tetratricopeptide repeat protein 26PRO_0000289082Add
BLAST

Proteomic databases

MaxQBiA0AVF1.
PaxDbiA0AVF1.
PRIDEiA0AVF1.

PTM databases

PhosphoSiteiA0AVF1.

Expressioni

Gene expression databases

BgeeiA0AVF1.
CleanExiHS_TTC26.
ExpressionAtlasiA0AVF1. baseline and differential.
GenevestigatoriA0AVF1.

Organism-specific databases

HPAiHPA036338.
HPA036339.

Interactioni

Protein-protein interaction databases

BioGridi123052. 5 interactions.
STRINGi9606.ENSP00000419279.

Structurei

3D structure databases

ProteinModelPortaliA0AVF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9034TPR 1Add
BLAST
Repeati92 – 12534TPR 2Add
BLAST
Repeati151 – 18434TPR 3Add
BLAST
Repeati468 – 50134TPR 4Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG297868.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiA0AVF1.
OMAiAINLKAC.
OrthoDBiEOG76MK86.
PhylomeDBiA0AVF1.
TreeFamiTF105816.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0AVF1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR
60 70 80 90 100
HVGEEEEDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT
110 120 130 140 150
YFFLGMYKQA EAAGFKASKS RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV
160 170 180 190 200
TEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY
210 220 230 240 250
YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA ELKSLMDNAS
260 270 280 290 300
SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
310 320 330 340 350
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG
360 370 380 390 400
GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA
410 420 430 440 450
QAKAATGNTS EGEEAFLLIQ SEKMKNDYIY LSWLARCYIM NKKPRLAWEL
460 470 480 490 500
YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK
510 520 530 540 550
RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI RIMKKWAKEN

RVSI
Length:554
Mass (Da):64,178
Last modified:November 28, 2006 - v1
Checksum:i188062024DB89B97
GO
Isoform 2 (identifier: A0AVF1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-554: MGQFYYSAKA...KWAKENRVSI → RDPSRSAPFTEKHR

Note: No experimental confirmation available.

Show »
Length:487
Mass (Da):56,352
Checksum:i231E1D9206AD04F0
GO
Isoform 3 (identifier: A0AVF1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-77: Missing.

Note: No experimental confirmation available.

Show »
Length:523
Mass (Da):60,469
Checksum:i5333FC397F119BDC
GO

Sequence cautioni

The sequence EAL24039.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851K → E in BAB14143. (PubMed:14702039)Curated
Sequence conflicti271 – 2711E → V in BAH12956. (PubMed:14702039)Curated
Sequence conflicti470 – 4701D → V in BAB14143. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101D → N.
Corresponds to variant rs13225917 [ dbSNP | Ensembl ].
VAR_032568

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 7731Missing in isoform 3. 1 PublicationVSP_044791Add
BLAST
Alternative sequencei474 – 55481MGQFY…NRVSI → RDPSRSAPFTEKHR in isoform 2. 1 PublicationVSP_043751Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022633 mRNA. Translation: BAB14143.1.
AK299132 mRNA. Translation: BAH12956.1.
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation.
BC126331 mRNA. Translation: AAI26332.1.
BC130339 mRNA. Translation: AAI30340.1.
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2.
CCDSiCCDS55172.1. [A0AVF1-2]
CCDS55173.1. [A0AVF1-3]
CCDS5852.1. [A0AVF1-1]
PIRiT46452.
RefSeqiNP_001138392.1. NM_001144920.2. [A0AVF1-2]
NP_001138395.1. NM_001144923.2. [A0AVF1-3]
NP_079202.2. NM_024926.3. [A0AVF1-1]
UniGeneiHs.133020.
Hs.644553.

Genome annotation databases

EnsembliENST00000343187; ENSP00000339135; ENSG00000105948. [A0AVF1-3]
ENST00000430935; ENSP00000410655; ENSG00000105948. [A0AVF1-2]
ENST00000464848; ENSP00000419279; ENSG00000105948. [A0AVF1-1]
GeneIDi79989.
KEGGihsa:79989.
UCSCiuc003vur.4. human. [A0AVF1-1]
uc011kqn.1. human. [A0AVF1-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022633 mRNA. Translation: BAB14143.1 .
AK299132 mRNA. Translation: BAH12956.1 .
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1 . Different initiation.
BC126331 mRNA. Translation: AAI26332.1 .
BC130339 mRNA. Translation: AAI30340.1 .
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2 .
CCDSi CCDS55172.1. [A0AVF1-2 ]
CCDS55173.1. [A0AVF1-3 ]
CCDS5852.1. [A0AVF1-1 ]
PIRi T46452.
RefSeqi NP_001138392.1. NM_001144920.2. [A0AVF1-2 ]
NP_001138395.1. NM_001144923.2. [A0AVF1-3 ]
NP_079202.2. NM_024926.3. [A0AVF1-1 ]
UniGenei Hs.133020.
Hs.644553.

3D structure databases

ProteinModelPortali A0AVF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123052. 5 interactions.
STRINGi 9606.ENSP00000419279.

PTM databases

PhosphoSitei A0AVF1.

Proteomic databases

MaxQBi A0AVF1.
PaxDbi A0AVF1.
PRIDEi A0AVF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343187 ; ENSP00000339135 ; ENSG00000105948 . [A0AVF1-3 ]
ENST00000430935 ; ENSP00000410655 ; ENSG00000105948 . [A0AVF1-2 ]
ENST00000464848 ; ENSP00000419279 ; ENSG00000105948 . [A0AVF1-1 ]
GeneIDi 79989.
KEGGi hsa:79989.
UCSCi uc003vur.4. human. [A0AVF1-1 ]
uc011kqn.1. human. [A0AVF1-2 ]

Organism-specific databases

CTDi 79989.
GeneCardsi GC07P138818.
H-InvDB HIX0007130.
HGNCi HGNC:21882. TTC26.
HPAi HPA036338.
HPA036339.
neXtProti NX_A0AVF1.
PharmGKBi PA144596245.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297868.
GeneTreei ENSGT00390000000159.
HOGENOMi HOG000258854.
HOVERGENi HBG108610.
InParanoidi A0AVF1.
OMAi AINLKAC.
OrthoDBi EOG76MK86.
PhylomeDBi A0AVF1.
TreeFami TF105816.

Miscellaneous databases

ChiTaRSi TTC26. human.
GenomeRNAii 79989.
NextBioi 70042.
PROi A0AVF1.

Gene expression databases

Bgeei A0AVF1.
CleanExi HS_TTC26.
ExpressionAtlasi A0AVF1. baseline and differential.
Genevestigatori A0AVF1.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 (ISOFORM 1/2).
    Tissue: Testis.

Entry informationi

Entry nameiTTC26_HUMAN
AccessioniPrimary (citable) accession number: A0AVF1
Secondary accession number(s): A4D1S3
, B7Z5M0, C9J2N7, F8W724, Q9H9S8, Q9NTC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3