SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0AVF1

- TTC26_HUMAN

UniProt

A0AVF1 - TTC26_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tetratricopeptide repeat protein 26
Gene
TTC26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a critical role in ciliogenesis and normal cilia function By similarity.

GO - Biological processi

  1. cilium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 26
Short name:
TPR repeat protein 26
Gene namesi
Name:TTC26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21882. TTC26.

Subcellular locationi

Cell projectioncilium By similarity
Note: Localizes at the base to the ciliary transition zone By similarity.

GO - Cellular componenti

  1. ciliary basal body Source: Ensembl
  2. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Tetratricopeptide repeat protein 26
PRO_0000289082Add
BLAST

Proteomic databases

MaxQBiA0AVF1.
PaxDbiA0AVF1.
PRIDEiA0AVF1.

PTM databases

PhosphoSiteiA0AVF1.

Expressioni

Gene expression databases

ArrayExpressiA0AVF1.
BgeeiA0AVF1.
CleanExiHS_TTC26.
GenevestigatoriA0AVF1.

Organism-specific databases

HPAiHPA036338.
HPA036339.

Interactioni

Protein-protein interaction databases

BioGridi123052. 1 interaction.
STRINGi9606.ENSP00000419279.

Structurei

3D structure databases

ProteinModelPortaliA0AVF1.
SMRiA0AVF1. Positions 60-128, 286-317, 399-453.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9034TPR 1
Add
BLAST
Repeati92 – 12534TPR 2
Add
BLAST
Repeati151 – 18434TPR 3
Add
BLAST
Repeati468 – 50134TPR 4
Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG297868.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiA0AVF1.
OMAiAINLKAC.
OrthoDBiEOG76MK86.
PhylomeDBiA0AVF1.
TreeFamiTF105816.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0AVF1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR    50
HVGEEEEDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT 100
YFFLGMYKQA EAAGFKASKS RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV 150
TEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY 200
YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA ELKSLMDNAS 250
SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD 300
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG 350
GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA 400
QAKAATGNTS EGEEAFLLIQ SEKMKNDYIY LSWLARCYIM NKKPRLAWEL 450
YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK 500
RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI RIMKKWAKEN 550
RVSI 554
Length:554
Mass (Da):64,178
Last modified:November 28, 2006 - v1
Checksum:i188062024DB89B97
GO
Isoform 2 (identifier: A0AVF1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-554: MGQFYYSAKA...KWAKENRVSI → RDPSRSAPFTEKHR

Note: No experimental confirmation available.

Show »
Length:487
Mass (Da):56,352
Checksum:i231E1D9206AD04F0
GO
Isoform 3 (identifier: A0AVF1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-77: Missing.

Note: No experimental confirmation available.

Show »
Length:523
Mass (Da):60,469
Checksum:i5333FC397F119BDC
GO

Sequence cautioni

The sequence EAL24039.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101D → N.
Corresponds to variant rs13225917 [ dbSNP | Ensembl ].
VAR_032568

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 7731Missing in isoform 3.
VSP_044791Add
BLAST
Alternative sequencei474 – 55481MGQFY…NRVSI → RDPSRSAPFTEKHR in isoform 2.
VSP_043751Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851K → E in BAB14143. 1 Publication
Sequence conflicti271 – 2711E → V in BAH12956. 1 Publication
Sequence conflicti470 – 4701D → V in BAB14143. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022633 mRNA. Translation: BAB14143.1.
AK299132 mRNA. Translation: BAH12956.1.
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation.
BC126331 mRNA. Translation: AAI26332.1.
BC130339 mRNA. Translation: AAI30340.1.
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2.
CCDSiCCDS55172.1. [A0AVF1-2]
CCDS55173.1. [A0AVF1-3]
CCDS5852.1. [A0AVF1-1]
PIRiT46452.
RefSeqiNP_001138392.1. NM_001144920.2. [A0AVF1-2]
NP_001138395.1. NM_001144923.2. [A0AVF1-3]
NP_079202.2. NM_024926.3. [A0AVF1-1]
UniGeneiHs.133020.
Hs.644553.

Genome annotation databases

EnsembliENST00000343187; ENSP00000339135; ENSG00000105948. [A0AVF1-3]
ENST00000430935; ENSP00000410655; ENSG00000105948. [A0AVF1-2]
ENST00000464848; ENSP00000419279; ENSG00000105948. [A0AVF1-1]
GeneIDi79989.
KEGGihsa:79989.
UCSCiuc003vur.4. human. [A0AVF1-1]
uc011kqn.1. human. [A0AVF1-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022633 mRNA. Translation: BAB14143.1 .
AK299132 mRNA. Translation: BAH12956.1 .
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1 . Different initiation.
BC126331 mRNA. Translation: AAI26332.1 .
BC130339 mRNA. Translation: AAI30340.1 .
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2 .
CCDSi CCDS55172.1. [A0AVF1-2 ]
CCDS55173.1. [A0AVF1-3 ]
CCDS5852.1. [A0AVF1-1 ]
PIRi T46452.
RefSeqi NP_001138392.1. NM_001144920.2. [A0AVF1-2 ]
NP_001138395.1. NM_001144923.2. [A0AVF1-3 ]
NP_079202.2. NM_024926.3. [A0AVF1-1 ]
UniGenei Hs.133020.
Hs.644553.

3D structure databases

ProteinModelPortali A0AVF1.
SMRi A0AVF1. Positions 60-128, 286-317, 399-453.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123052. 1 interaction.
STRINGi 9606.ENSP00000419279.

PTM databases

PhosphoSitei A0AVF1.

Proteomic databases

MaxQBi A0AVF1.
PaxDbi A0AVF1.
PRIDEi A0AVF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343187 ; ENSP00000339135 ; ENSG00000105948 . [A0AVF1-3 ]
ENST00000430935 ; ENSP00000410655 ; ENSG00000105948 . [A0AVF1-2 ]
ENST00000464848 ; ENSP00000419279 ; ENSG00000105948 . [A0AVF1-1 ]
GeneIDi 79989.
KEGGi hsa:79989.
UCSCi uc003vur.4. human. [A0AVF1-1 ]
uc011kqn.1. human. [A0AVF1-2 ]

Organism-specific databases

CTDi 79989.
GeneCardsi GC07P138818.
H-InvDB HIX0007130.
HGNCi HGNC:21882. TTC26.
HPAi HPA036338.
HPA036339.
neXtProti NX_A0AVF1.
PharmGKBi PA144596245.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297868.
HOGENOMi HOG000258854.
HOVERGENi HBG108610.
InParanoidi A0AVF1.
OMAi AINLKAC.
OrthoDBi EOG76MK86.
PhylomeDBi A0AVF1.
TreeFami TF105816.

Miscellaneous databases

ChiTaRSi TTC26. human.
GenomeRNAii 79989.
NextBioi 70042.
PROi A0AVF1.

Gene expression databases

ArrayExpressi A0AVF1.
Bgeei A0AVF1.
CleanExi HS_TTC26.
Genevestigatori A0AVF1.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 (ISOFORM 1/2).
    Tissue: Testis.

Entry informationi

Entry nameiTTC26_HUMAN
AccessioniPrimary (citable) accession number: A0AVF1
Secondary accession number(s): A4D1S3
, B7Z5M0, C9J2N7, F8W724, Q9H9S8, Q9NTC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi