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Protein

Intraflagellar transport protein 56

Gene

TTC26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_268024. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 56By similarity
Alternative name(s):
Tetratricopeptide repeat protein 26Imported
Short name:
TPR repeat protein 26Imported
Gene namesi
Name:TTC26Imported
Synonyms:IFT56By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21882. TTC26.

Subcellular locationi

  • Cell projectioncilium By similarity

  • Note: Localizes at the base to the ciliary transition zone.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Intraflagellar transport protein 56PRO_0000289082Add
BLAST

Proteomic databases

MaxQBiA0AVF1.
PaxDbiA0AVF1.
PRIDEiA0AVF1.

PTM databases

PhosphoSiteiA0AVF1.

Expressioni

Gene expression databases

BgeeiA0AVF1.
CleanExiHS_TTC26.
ExpressionAtlasiA0AVF1. baseline and differential.
GenevisibleiA0AVF1. HS.

Organism-specific databases

HPAiHPA036338.
HPA036339.

Interactioni

Subunit structurei

Component of the IFT complex B. Interacts with IFT46; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi123052. 6 interactions.
STRINGi9606.ENSP00000419279.

Structurei

3D structure databases

ProteinModelPortaliA0AVF1.
SMRiA0AVF1. Positions 286-317, 399-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9034TPR 1Add
BLAST
Repeati92 – 12534TPR 2Add
BLAST
Repeati151 – 18434TPR 3Add
BLAST
Repeati468 – 50134TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the IFT56 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG297868.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiA0AVF1.
OMAiDLWIGYC.
OrthoDBiEOG76MK86.
PhylomeDBiA0AVF1.
TreeFamiTF105816.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0AVF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR
60 70 80 90 100
HVGEEEEDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT
110 120 130 140 150
YFFLGMYKQA EAAGFKASKS RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV
160 170 180 190 200
TEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY
210 220 230 240 250
YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA ELKSLMDNAS
260 270 280 290 300
SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
310 320 330 340 350
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG
360 370 380 390 400
GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA
410 420 430 440 450
QAKAATGNTS EGEEAFLLIQ SEKMKNDYIY LSWLARCYIM NKKPRLAWEL
460 470 480 490 500
YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK
510 520 530 540 550
RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI RIMKKWAKEN

RVSI
Length:554
Mass (Da):64,178
Last modified:November 28, 2006 - v1
Checksum:i188062024DB89B97
GO
Isoform 2 (identifier: A0AVF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-554: MGQFYYSAKA...KWAKENRVSI → RDPSRSAPFTEKHR

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):56,352
Checksum:i231E1D9206AD04F0
GO
Isoform 3 (identifier: A0AVF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-77: Missing.

Note: No experimental confirmation available.
Show »
Length:523
Mass (Da):60,469
Checksum:i5333FC397F119BDC
GO

Sequence cautioni

The sequence EAL24039.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851K → E in BAB14143 (PubMed:14702039).Curated
Sequence conflicti271 – 2711E → V in BAH12956 (PubMed:14702039).Curated
Sequence conflicti470 – 4701D → V in BAB14143 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101D → N.
Corresponds to variant rs13225917 [ dbSNP | Ensembl ].
VAR_032568

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 7731Missing in isoform 3. 1 PublicationVSP_044791Add
BLAST
Alternative sequencei474 – 55481MGQFY…NRVSI → RDPSRSAPFTEKHR in isoform 2. 1 PublicationVSP_043751Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022633 mRNA. Translation: BAB14143.1.
AK299132 mRNA. Translation: BAH12956.1.
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation.
BC126331 mRNA. Translation: AAI26332.1.
BC130339 mRNA. Translation: AAI30340.1.
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2.
CCDSiCCDS55172.1. [A0AVF1-2]
CCDS55173.1. [A0AVF1-3]
CCDS5852.1. [A0AVF1-1]
PIRiT46452.
RefSeqiNP_001138392.1. NM_001144920.2. [A0AVF1-2]
NP_001138395.1. NM_001144923.2. [A0AVF1-3]
NP_079202.2. NM_024926.3. [A0AVF1-1]
UniGeneiHs.133020.
Hs.644553.

Genome annotation databases

EnsembliENST00000343187; ENSP00000339135; ENSG00000105948. [A0AVF1-3]
ENST00000430935; ENSP00000410655; ENSG00000105948. [A0AVF1-2]
ENST00000464848; ENSP00000419279; ENSG00000105948. [A0AVF1-1]
GeneIDi79989.
KEGGihsa:79989.
UCSCiuc003vur.4. human. [A0AVF1-1]
uc011kqn.1. human. [A0AVF1-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022633 mRNA. Translation: BAB14143.1.
AK299132 mRNA. Translation: BAH12956.1.
AC009220 Genomic DNA. No translation available.
AC018644 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation.
BC126331 mRNA. Translation: AAI26332.1.
BC130339 mRNA. Translation: AAI30340.1.
BC144151 mRNA. No translation available.
AL137393 mRNA. Translation: CAB70721.2.
CCDSiCCDS55172.1. [A0AVF1-2]
CCDS55173.1. [A0AVF1-3]
CCDS5852.1. [A0AVF1-1]
PIRiT46452.
RefSeqiNP_001138392.1. NM_001144920.2. [A0AVF1-2]
NP_001138395.1. NM_001144923.2. [A0AVF1-3]
NP_079202.2. NM_024926.3. [A0AVF1-1]
UniGeneiHs.133020.
Hs.644553.

3D structure databases

ProteinModelPortaliA0AVF1.
SMRiA0AVF1. Positions 286-317, 399-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123052. 6 interactions.
STRINGi9606.ENSP00000419279.

PTM databases

PhosphoSiteiA0AVF1.

Proteomic databases

MaxQBiA0AVF1.
PaxDbiA0AVF1.
PRIDEiA0AVF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343187; ENSP00000339135; ENSG00000105948. [A0AVF1-3]
ENST00000430935; ENSP00000410655; ENSG00000105948. [A0AVF1-2]
ENST00000464848; ENSP00000419279; ENSG00000105948. [A0AVF1-1]
GeneIDi79989.
KEGGihsa:79989.
UCSCiuc003vur.4. human. [A0AVF1-1]
uc011kqn.1. human. [A0AVF1-2]

Organism-specific databases

CTDi79989.
GeneCardsiGC07P138818.
H-InvDBHIX0007130.
HGNCiHGNC:21882. TTC26.
HPAiHPA036338.
HPA036339.
neXtProtiNX_A0AVF1.
PharmGKBiPA144596245.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297868.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiA0AVF1.
OMAiDLWIGYC.
OrthoDBiEOG76MK86.
PhylomeDBiA0AVF1.
TreeFamiTF105816.

Enzyme and pathway databases

ReactomeiREACT_268024. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiTTC26. human.
GenomeRNAii79989.
NextBioi70042.
PROiA0AVF1.

Gene expression databases

BgeeiA0AVF1.
CleanExiHS_TTC26.
ExpressionAtlasiA0AVF1. baseline and differential.
GenevisibleiA0AVF1. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 (ISOFORM 1/2).
    Tissue: Testis.

Entry informationi

Entry nameiIFT56_HUMAN
AccessioniPrimary (citable) accession number: A0AVF1
Secondary accession number(s): A4D1S3
, B7Z5M0, C9J2N7, F8W724, Q9H9S8, Q9NTC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 28, 2006
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.