A0AVF1 (TTC26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetratricopeptide repeat protein 26
Short name=TPR repeat protein 26

Gene names

Name:

TTC26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a critical role in ciliogenesis and normal cilia function By similarity.
Subcellular location	Cell projection › cilium By similarity. Note: Localizes at the base to the ciliary transition zone By similarity.
Sequence similarities	Contains 4 TPR repeats.
Sequence caution	The sequence EAL24039.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cilium
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	primary cilium Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0AVF1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0AVF1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     474-554: MGQFYYSAKA...KWAKENRVSI → RDPSRSAPFTEKHR

Note: No experimental confirmation available.

Isoform 3 (identifier: A0AVF1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     47-77: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Tetratricopeptide repeat protein 26		PRO_0000289082
Regions
	Repeat	57 – 90	34	TPR 1
	Repeat	92 – 125	34	TPR 2
	Repeat	151 – 184	34	TPR 3
	Repeat	468 – 501	34	TPR 4
Natural variations
	Alternative sequence	47 – 77	31	Missing in isoform 3.		VSP_044791
	Alternative sequence	474 – 554	81	MGQFY…NRVSI → RDPSRSAPFTEKHR in isoform 2.		VSP_043751
	Natural variant	310	1	D → N. Corresponds to variant rs13225917 [ dbSNP | Ensembl ].		VAR_032568
Experimental info
	Sequence conflict	85	1	K → E in BAB14143. Ref.1
	Sequence conflict	271	1	E → V in BAH12956. Ref.1
	Sequence conflict	470	1	D → V in BAB14143. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 188062024DB89B97	FASTA	554	64,178
	10 20 30 40 50 60 MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR HVGEEEEDTN 70 80 90 100 110 120 LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT YFFLGMYKQA EAAGFKASKS 130 140 150 160 170 180 RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV TEDQLSLASI HYMRSHYQEA IDIYKRILLD 190 200 210 220 230 240 NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA 250 260 270 280 290 300 ELKSLMDNAS SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD 310 320 330 340 350 360 VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP 370 380 390 400 410 420 GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEAFLLIQ 430 440 450 460 470 480 SEKMKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS 490 500 510 520 530 540 AKAFDVLERL DPNPEYWEGK RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI 550 RIMKKWAKEN RVSI
	Isoform 2 [UniParc]. Checksum: 231E1D9206AD04F0	FASTA	487	56,352
	10 20 30 40 50 60 MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR HVGEEEEDTN 70 80 90 100 110 120 LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT YFFLGMYKQA EAAGFKASKS 130 140 150 160 170 180 RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV TEDQLSLASI HYMRSHYQEA IDIYKRILLD 190 200 210 220 230 240 NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA 250 260 270 280 290 300 ELKSLMDNAS SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD 310 320 330 340 350 360 VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP 370 380 390 400 410 420 GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEAFLLIQ 430 440 450 460 470 480 SEKMKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKRDPSRSA PFTEKHR
	Isoform 3 [UniParc]. Checksum: 5333FC397F119BDC	FASTA	523	60,469
	10 20 30 40 50 60 MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEEYE NATKEENCNS 70 80 90 100 110 120 EVWVNLACTY FFLGMYKQAE AAGFKASKSR LQNRLLFHLA HKFNDEKKLM SFHQNLQDVT 130 140 150 160 170 180 EDQLSLASIH YMRSHYQEAI DIYKRILLDN REYLALNVYV ALCYYKLDYY DVSQEVLAVY 190 200 210 220 230 240 LQQIPDSTIA LNLKACNHFR LYNGRAAEAE LKSLMDNASS SFEFAKELIR HNLVVFRGGE 250 260 270 280 290 300 GALQVLPPLV DVIPEARLNL VIYYLRQDDV QEAYNLIKDL EPTTPQEYIL KGVVNAALGQ 310 320 330 340 350 360 EMGSRDHMKI AQQFFQLVGG SASECDTIPG RQCMASCFFL LKQFDDVLIY LNSFKSYFYN 370 380 390 400 410 420 DDIFNFNYAQ AKAATGNTSE GEEAFLLIQS EKMKNDYIYL SWLARCYIMN KKPRLAWELY 430 440 450 460 470 480 LKMETSGESF SLLQLIANDC YKMGQFYYSA KAFDVLERLD PNPEYWEGKR GACVGIFQMI 490 500 510 520 IAGREPKETL REVLHLLRST GNTQVEYMIR IMKKWAKENR VSI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 (ISOFORM 1/2). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022633 mRNA. Translation: BAB14143.1. AK299132 mRNA. Translation: BAH12956.1. AC009220 Genomic DNA. No translation available. AC018644 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation. BC126331 mRNA. Translation: AAI26332.1. BC130339 mRNA. Translation: AAI30340.1. BC144151 mRNA. No translation available. AL137393 mRNA. Translation: CAB70721.2.
IPI	IPI00328172. IPI00921448. IPI00946826.
PIR	T46452.
RefSeq	NP_001138392.1. NM_001144920.1. NP_001138395.1. NM_001144923.1. NP_079202.2. NM_024926.2.
UniGene	Hs.644553.
3D structure databases
ProteinModelPortal	A0AVF1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000419279.
PTM databases
PhosphoSite	A0AVF1.
Proteomic databases
PaxDb	A0AVF1.
PRIDE	A0AVF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343187; ENSP00000339135; ENSG00000105948. ENST00000430935; ENSP00000410655; ENSG00000105948. ENST00000464848; ENSP00000419279; ENSG00000105948.
GeneID	79989.
KEGG	hsa:79989.
UCSC	uc003vur.4. human. uc011kqn.1. human. uc011kqo.1. human.
Organism-specific databases
CTD	79989.
GeneCards	GC07P138818.
H-InvDB	HIX0007130.
HGNC	HGNC:21882. TTC26.
HPA	HPA036338. HPA036339.
neXtProt	NX_A0AVF1.
PharmGKB	PA144596245.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297868.
HOGENOM	HOG000258854.
HOVERGEN	HBG108610.
InParanoid	A0AVF1.
OMA	FFLLRQF.
OrthoDB	EOG4WWRJ5.
PhylomeDB	A0AVF1.
Gene expression databases
ArrayExpress	A0AVF1.
Bgee	A0AVF1.
CleanEx	HS_TTC26.
Genevestigator	A0AVF1.
Family and domain databases
Gene3D	1.25.40.10. 3 hits.
InterPro	IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TTC26. human.
GenomeRNAi	79989.
NextBio	70042.

Entry information

Entry name

TTC26_HUMAN

Accession

Primary (citable) accession number: A0AVF1
Secondary accession number(s): A4D1S3 , B7Z5M0, C9J2N7, F8W724, Q9H9S8, Q9NTC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 28, 2006
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.