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A0AVF1

- TTC26_HUMAN

UniProt

A0AVF1 - TTC26_HUMAN

Protein

Tetratricopeptide repeat protein 26

Gene

TTC26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    May play a critical role in ciliogenesis and normal cilia function.By similarity

    GO - Biological processi

    1. cilium assembly Source: UniProtKB

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetratricopeptide repeat protein 26
    Short name:
    TPR repeat protein 26
    Gene namesi
    Name:TTC26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21882. TTC26.

    Subcellular locationi

    Cell projectioncilium By similarity
    Note: Localizes at the base to the ciliary transition zone.By similarity

    GO - Cellular componenti

    1. ciliary basal body Source: Ensembl
    2. primary cilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596245.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Tetratricopeptide repeat protein 26PRO_0000289082Add
    BLAST

    Proteomic databases

    MaxQBiA0AVF1.
    PaxDbiA0AVF1.
    PRIDEiA0AVF1.

    PTM databases

    PhosphoSiteiA0AVF1.

    Expressioni

    Gene expression databases

    ArrayExpressiA0AVF1.
    BgeeiA0AVF1.
    CleanExiHS_TTC26.
    GenevestigatoriA0AVF1.

    Organism-specific databases

    HPAiHPA036338.
    HPA036339.

    Interactioni

    Protein-protein interaction databases

    BioGridi123052. 1 interaction.
    STRINGi9606.ENSP00000419279.

    Structurei

    3D structure databases

    ProteinModelPortaliA0AVF1.
    SMRiA0AVF1. Positions 60-128, 286-317, 399-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 9034TPR 1Add
    BLAST
    Repeati92 – 12534TPR 2Add
    BLAST
    Repeati151 – 18434TPR 3Add
    BLAST
    Repeati468 – 50134TPR 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG297868.
    HOGENOMiHOG000258854.
    HOVERGENiHBG108610.
    InParanoidiA0AVF1.
    OMAiAINLKAC.
    OrthoDBiEOG76MK86.
    PhylomeDBiA0AVF1.
    TreeFamiTF105816.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PROSITEiPS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A0AVF1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR    50
    HVGEEEEDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT 100
    YFFLGMYKQA EAAGFKASKS RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV 150
    TEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY 200
    YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA ELKSLMDNAS 250
    SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD 300
    VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG 350
    GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA 400
    QAKAATGNTS EGEEAFLLIQ SEKMKNDYIY LSWLARCYIM NKKPRLAWEL 450
    YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK 500
    RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI RIMKKWAKEN 550
    RVSI 554
    Length:554
    Mass (Da):64,178
    Last modified:November 28, 2006 - v1
    Checksum:i188062024DB89B97
    GO
    Isoform 2 (identifier: A0AVF1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         474-554: MGQFYYSAKA...KWAKENRVSI → RDPSRSAPFTEKHR

    Note: No experimental confirmation available.

    Show »
    Length:487
    Mass (Da):56,352
    Checksum:i231E1D9206AD04F0
    GO
    Isoform 3 (identifier: A0AVF1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-77: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:523
    Mass (Da):60,469
    Checksum:i5333FC397F119BDC
    GO

    Sequence cautioni

    The sequence EAL24039.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851K → E in BAB14143. (PubMed:14702039)Curated
    Sequence conflicti271 – 2711E → V in BAH12956. (PubMed:14702039)Curated
    Sequence conflicti470 – 4701D → V in BAB14143. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti310 – 3101D → N.
    Corresponds to variant rs13225917 [ dbSNP | Ensembl ].
    VAR_032568

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 7731Missing in isoform 3. 1 PublicationVSP_044791Add
    BLAST
    Alternative sequencei474 – 55481MGQFY…NRVSI → RDPSRSAPFTEKHR in isoform 2. 1 PublicationVSP_043751Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022633 mRNA. Translation: BAB14143.1.
    AK299132 mRNA. Translation: BAH12956.1.
    AC009220 Genomic DNA. No translation available.
    AC018644 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24039.1. Different initiation.
    BC126331 mRNA. Translation: AAI26332.1.
    BC130339 mRNA. Translation: AAI30340.1.
    BC144151 mRNA. No translation available.
    AL137393 mRNA. Translation: CAB70721.2.
    CCDSiCCDS55172.1. [A0AVF1-2]
    CCDS55173.1. [A0AVF1-3]
    CCDS5852.1. [A0AVF1-1]
    PIRiT46452.
    RefSeqiNP_001138392.1. NM_001144920.2. [A0AVF1-2]
    NP_001138395.1. NM_001144923.2. [A0AVF1-3]
    NP_079202.2. NM_024926.3. [A0AVF1-1]
    UniGeneiHs.133020.
    Hs.644553.

    Genome annotation databases

    EnsembliENST00000343187; ENSP00000339135; ENSG00000105948. [A0AVF1-3]
    ENST00000430935; ENSP00000410655; ENSG00000105948. [A0AVF1-2]
    ENST00000464848; ENSP00000419279; ENSG00000105948. [A0AVF1-1]
    GeneIDi79989.
    KEGGihsa:79989.
    UCSCiuc003vur.4. human. [A0AVF1-1]
    uc011kqn.1. human. [A0AVF1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022633 mRNA. Translation: BAB14143.1 .
    AK299132 mRNA. Translation: BAH12956.1 .
    AC009220 Genomic DNA. No translation available.
    AC018644 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24039.1 . Different initiation.
    BC126331 mRNA. Translation: AAI26332.1 .
    BC130339 mRNA. Translation: AAI30340.1 .
    BC144151 mRNA. No translation available.
    AL137393 mRNA. Translation: CAB70721.2 .
    CCDSi CCDS55172.1. [A0AVF1-2 ]
    CCDS55173.1. [A0AVF1-3 ]
    CCDS5852.1. [A0AVF1-1 ]
    PIRi T46452.
    RefSeqi NP_001138392.1. NM_001144920.2. [A0AVF1-2 ]
    NP_001138395.1. NM_001144923.2. [A0AVF1-3 ]
    NP_079202.2. NM_024926.3. [A0AVF1-1 ]
    UniGenei Hs.133020.
    Hs.644553.

    3D structure databases

    ProteinModelPortali A0AVF1.
    SMRi A0AVF1. Positions 60-128, 286-317, 399-453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123052. 1 interaction.
    STRINGi 9606.ENSP00000419279.

    PTM databases

    PhosphoSitei A0AVF1.

    Proteomic databases

    MaxQBi A0AVF1.
    PaxDbi A0AVF1.
    PRIDEi A0AVF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343187 ; ENSP00000339135 ; ENSG00000105948 . [A0AVF1-3 ]
    ENST00000430935 ; ENSP00000410655 ; ENSG00000105948 . [A0AVF1-2 ]
    ENST00000464848 ; ENSP00000419279 ; ENSG00000105948 . [A0AVF1-1 ]
    GeneIDi 79989.
    KEGGi hsa:79989.
    UCSCi uc003vur.4. human. [A0AVF1-1 ]
    uc011kqn.1. human. [A0AVF1-2 ]

    Organism-specific databases

    CTDi 79989.
    GeneCardsi GC07P138818.
    H-InvDB HIX0007130.
    HGNCi HGNC:21882. TTC26.
    HPAi HPA036338.
    HPA036339.
    neXtProti NX_A0AVF1.
    PharmGKBi PA144596245.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297868.
    HOGENOMi HOG000258854.
    HOVERGENi HBG108610.
    InParanoidi A0AVF1.
    OMAi AINLKAC.
    OrthoDBi EOG76MK86.
    PhylomeDBi A0AVF1.
    TreeFami TF105816.

    Miscellaneous databases

    ChiTaRSi TTC26. human.
    GenomeRNAii 79989.
    NextBioi 70042.
    PROi A0AVF1.

    Gene expression databases

    ArrayExpressi A0AVF1.
    Bgeei A0AVF1.
    CleanExi HS_TTC26.
    Genevestigatori A0AVF1.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PROSITEi PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 (ISOFORM 1/2).
      Tissue: Testis.

    Entry informationi

    Entry nameiTTC26_HUMAN
    AccessioniPrimary (citable) accession number: A0AVF1
    Secondary accession number(s): A4D1S3
    , B7Z5M0, C9J2N7, F8W724, Q9H9S8, Q9NTC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3