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Protein

RNA-binding protein 47

Gene

RBM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 47
Alternative name(s):
RNA-binding motif protein 47
Gene namesi
Name:RBM47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163694.14
HGNCiHGNC:30358 RBM47
neXtProtiNX_A0AV96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54502
OpenTargetsiENSG00000163694
PharmGKBiPA162400825

Polymorphism and mutation databases

BioMutaiRBM47

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078551 – 593RNA-binding protein 47Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332Omega-N-methylarginineCombined sources1
Modified residuei394Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei394Omega-N-methylarginine; alternateCombined sources1
Modified residuei405Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei405Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiA0AV96
MaxQBiA0AV96
PaxDbiA0AV96
PRIDEiA0AV96

PTM databases

iPTMnetiA0AV96
PhosphoSitePlusiA0AV96

Expressioni

Gene expression databases

BgeeiENSG00000163694
CleanExiHS_RBM47
ExpressionAtlasiA0AV96 baseline and differential
GenevisibleiA0AV96 HS

Organism-specific databases

HPAiHPA006347

Interactioni

Protein-protein interaction databases

BioGridi119998, 55 interactors
IntActiA0AV96, 14 interactors
STRINGi9606.ENSP00000295971

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi150 – 156Combined sources7
Helixi164 – 174Combined sources11
Beta strandi178 – 182Combined sources5
Beta strandi185 – 187Combined sources3
Turni189 – 193Combined sources5
Beta strandi196 – 203Combined sources8
Helixi204 – 211Combined sources8
Turni212 – 216Combined sources5
Beta strandi227 – 231Combined sources5
Turni237 – 239Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DISNMR-A150-245[»]
ProteinModelPortaliA0AV96
SMRiA0AV96
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0AV96

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 149RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini151 – 233RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini246 – 318RRM 3PROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi487 – 581Ala-richAdd BLAST95

Sequence similaritiesi

Belongs to the RRM RBM47 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000186083
HOVERGENiHBG051917
InParanoidiA0AV96
OMAiIGPNREY
OrthoDBiEOG091G0EUB
PhylomeDBiA0AV96
TreeFamiTF314932

Family and domain databases

CDDicd12491 RRM2_RBM47, 1 hit
cd12497 RRM3_RBM47, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006535 HnRNP_R/Q_splicing_fac
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034442 RBM47
IPR034440 RBM47_RRM2
IPR034445 RBM47_RRM3
IPR000504 RRM_dom
PANTHERiPTHR43980:SF4 PTHR43980:SF4, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0AV96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAEDSTAAM SSDSAAGSSA KVPEGVAGAP NEAALLALME RTGYSMVQEN
60 70 80 90 100
GQRKYGGPPP GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FEAVGRIYEL
110 120 130 140 150
RLMMDFDGKN RGYAFVMYCH KHEAKRAVRE LNNYEIRPGR LLGVCCSVDN
160 170 180 190 200
CRLFIGGIPK MKKREEILEE IAKVTEGVLD VIVYASAADK MKNRGFAFVE
210 220 230 240 250
YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED VMETVKILYV
260 270 280 290 300
RNLMIETTED TIKKSFGQFN PGCVERVKKI RDYAFVHFTS REDAVHAMNN
310 320 330 340 350
LNGTELEGSC LEVTLAKPVD KEQYSRYQKA ARGGGAAEAA QQPSYVYSCD
360 370 380 390 400
PYTLAYYGYP YNALIGPNRD YFVKAGSIRG RGRGAAGNRA PGPRGSYLGG
410 420 430 440 450
YSAGRGIYSR YHEGKGKQQE KGYELVPNLE IPTVNPVAIK PGTVAIPAIG
460 470 480 490 500
AQYSMFPAAP APKMIEDGKI HTVEHMISPI AVQPDPASAA AAAAAAAAAA
510 520 530 540 550
AAVIPTVSTP PPFQGRPITP VYTVAPNVQR IPTAGIYGAS YVPFAAPATA
560 570 580 590
TIATLQKNAA AAAAMYGGYA GYIPQAFPAA AIQVPIPDVY QTY
Length:593
Mass (Da):64,099
Last modified:November 30, 2010 - v2
Checksum:iAEA061F89A68010B
GO
Isoform 2 (identifier: A0AV96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-443: Missing.

Show »
Length:524
Mass (Da):56,920
Checksum:i4C7004D92117D5B1
GO

Sequence cautioni

The sequence AAM21973 differs from that shown. Reason: Frameshift at positions 561 and 577.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → T in AAM21973 (Ref. 1) Curated1
Sequence conflicti97I → T in BAA91049 (PubMed:14702039).Curated1
Sequence conflicti515G → V in AAM21972 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061832538G → R. Corresponds to variant dbSNP:rs35529250Ensembl.1
Natural variantiVAR_054770565M → V2 PublicationsCorresponds to variant dbSNP:rs278981Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028839375 – 443Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261889 Genomic DNA Translation: AAM21972.1
AF262323 mRNA Translation: AAM21973.1 Frameshift.
AK000280 mRNA Translation: BAA91049.1
AC098869 Genomic DNA No translation available.
AC112717 Genomic DNA No translation available.
BC034402 mRNA Translation: AAH34402.1
BC126261 mRNA Translation: AAI26262.1
CCDSiCCDS3460.1 [A0AV96-2]
CCDS43223.1 [A0AV96-1]
RefSeqiNP_001092104.1, NM_001098634.1 [A0AV96-1]
NP_061900.2, NM_019027.3 [A0AV96-2]
XP_005248160.1, XM_005248103.3 [A0AV96-1]
XP_005248164.1, XM_005248107.3 [A0AV96-1]
XP_005248165.1, XM_005248108.3 [A0AV96-1]
XP_005248166.1, XM_005248109.4 [A0AV96-1]
XP_011512006.1, XM_011513704.2 [A0AV96-1]
XP_011512009.1, XM_011513707.2 [A0AV96-1]
XP_011512010.1, XM_011513708.2 [A0AV96-1]
XP_016863793.1, XM_017008304.1 [A0AV96-1]
XP_016863794.1, XM_017008305.1 [A0AV96-1]
XP_016863795.1, XM_017008306.1 [A0AV96-1]
XP_016863796.1, XM_017008307.1 [A0AV96-1]
XP_016863797.1, XM_017008308.1 [A0AV96-1]
XP_016863799.1, XM_017008310.1 [A0AV96-2]
UniGeneiHs.518727

Genome annotation databases

EnsembliENST00000295971; ENSP00000295971; ENSG00000163694 [A0AV96-1]
ENST00000381793; ENSP00000371212; ENSG00000163694 [A0AV96-1]
ENST00000381795; ENSP00000371214; ENSG00000163694 [A0AV96-2]
GeneIDi54502
KEGGihsa:54502
UCSCiuc003gvc.3 human [A0AV96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM47_HUMAN
AccessioniPrimary (citable) accession number: A0AV96
Secondary accession number(s): A0PJK2
, B5MED4, Q8NI52, Q8NI53, Q9NXG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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