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Protein
Submitted name:

Topoisomerase (DNA) II binding protein 1

Gene

TOPBP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

SignaLinkiA0AV47.

Names & Taxonomyi

Protein namesi
Submitted name:
Topoisomerase (DNA) II binding protein 1Imported
Gene namesi
Name:TOPBP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934073.

PTM / Processingi

Proteomic databases

PaxDbiA0AV47.
PeptideAtlasiA0AV47.
PRIDEiA0AV47.

Expressioni

Gene expression databases

BgeeiA0AV47.
GenevisibleiA0AV47. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260810.

Structurei

3D structure databases

ProteinModelPortaliA0AV47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572BRCTInterPro annotationAdd
BLAST
Domaini108 – 19790BRCTInterPro annotationAdd
BLAST
Domaini267 – 35791BRCTInterPro annotationAdd
BLAST
Domaini461 – 54686BRCTInterPro annotationAdd
BLAST
Domaini554 – 65198BRCTInterPro annotationAdd
BLAST
Domaini813 – 90492BRCTInterPro annotationAdd
BLAST
Domaini1172 – 126493BRCTInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1929. Eukaryota.
ENOG410XPFH. LUCA.
HOVERGENiHBG067053.
KOiK10728.

Family and domain databases

Gene3Di3.40.50.10190. 6 hits.
InterProiIPR001357. BRCT_dom.
IPR016126. Secretoglobin.
IPR026993. Topbp1.
[Graphical view]
PANTHERiPTHR13561:SF32. PTHR13561:SF32. 2 hits.
PfamiPF00533. BRCT. 4 hits.
PF12738. PTCB-BRCT. 2 hits.
[Graphical view]
SMARTiSM00292. BRCT. 7 hits.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
SSF52113. SSF52113. 6 hits.
PROSITEiPS50172. BRCT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0AV47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR
60 70 80 90 100
DLNVSVTHLI AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY
110 120 130 140 150
TDINMEDFKC PIFLGCIICV TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE
160 170 180 190 200
CTHLIVQEPK GQKYECAKRW NVHCVTTQWF FDSIEKGFCQ DESIYKTEPR
210 220 230 240 250
PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE SICNSLNSKL
260 270 280 290 300
EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV
310 320 330 340 350
RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML
360 370 380 390 400
SEEPYIHANY QPVEIPVSHK PESKAALLKK KNSSFSKKDF APSEKHEQAD
410 420 430 440 450
EDLLSQYENG SSTVVEAKTS EARPFNDSTH AEPLNDSTHI SLQEENQSSV
460 470 480 490 500
SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN ESNIANIIKE NAGKIMSLLS
510 520 530 540 550
RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD PKSNPLFTPV
560 570 580 590 600
PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK
610 620 630 640 650
GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL
660 670 680 690 700
IENSTKEERS LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ
710 720 730 740 750
SKAFRAVVSQ HARQVAASPA VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF
760 770 780 790 800
DVKDALAALE TPGRPSQQKR KPSTPLSEVI VKNLQLALAN SSRNAVALSA
810 820 830 840 850
SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA ASLGADYRWS
860 870 880 890 900
FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES
910 920 930 940 950
LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD
960 970 980 990 1000
NMATNNKESA PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP
1010 1020 1030 1040 1050
QGQRTSLSRS GCNSASSTPD STRSARSGRS RVLEALRQSR QTVPDVNTEP
1060 1070 1080 1090 1100
SQNEQIIWDD PTAREERARL ASNLQWPSCP TQYSELQVDI QNLEDSPFQK
1110 1120 1130 1140 1150
PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH LIPTPQAPSI
1160 1170 1180 1190 1200
AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI
1210 1220 1230 1240 1250
EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC
1260 1270 1280 1290 1300
RTAGHFVQEE DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES
1310 1320 1330 1340 1350
GIVEGAFSGW KVILHVDQSR EAGFKRLLQS GGAKVLPGHS VPLFKEATHL
1360 1370 1380 1390 1400
FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE YIADYLMQES PPHVENYCLP
1410 1420 1430
EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH
Length:1,435
Mass (Da):160,551
Last modified:April 17, 2007 - v2
Checksum:i959EFEBEF5257B00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126209 mRNA. Translation: AAI26210.2.
RefSeqiNP_008958.2. NM_007027.3.
UniGeneiHs.593379.

Genome annotation databases

GeneIDi11073.
KEGGihsa:11073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126209 mRNA. Translation: AAI26210.2.
RefSeqiNP_008958.2. NM_007027.3.
UniGeneiHs.593379.

3D structure databases

ProteinModelPortaliA0AV47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260810.

Proteomic databases

PaxDbiA0AV47.
PeptideAtlasiA0AV47.
PRIDEiA0AV47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11073.
KEGGihsa:11073.

Organism-specific databases

CTDi11073.
PharmGKBiPA134934073.

Phylogenomic databases

eggNOGiKOG1929. Eukaryota.
ENOG410XPFH. LUCA.
HOVERGENiHBG067053.
KOiK10728.

Enzyme and pathway databases

SignaLinkiA0AV47.

Miscellaneous databases

ChiTaRSiTOPBP1. human.
GenomeRNAii11073.

Gene expression databases

BgeeiA0AV47.
GenevisibleiA0AV47. HS.

Family and domain databases

Gene3Di3.40.50.10190. 6 hits.
InterProiIPR001357. BRCT_dom.
IPR016126. Secretoglobin.
IPR026993. Topbp1.
[Graphical view]
PANTHERiPTHR13561:SF32. PTHR13561:SF32. 2 hits.
PfamiPF00533. BRCT. 4 hits.
PF12738. PTCB-BRCT. 2 hits.
[Graphical view]
SMARTiSM00292. BRCT. 7 hits.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
SSF52113. SSF52113. 6 hits.
PROSITEiPS50172. BRCT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiA0AV47_HUMAN
AccessioniPrimary (citable) accession number: A0AV47
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: April 17, 2007
Last modified: July 6, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.