ID S12A8_HUMAN Reviewed; 714 AA. AC A0AV02; C9JJJ2; Q68D04; Q6I9Z2; Q6P4C0; Q7Z3A6; Q86WK0; Q8NFX9; Q8WUI3; AC Q96RF9; Q9H5P9; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 27-MAY-2015, sequence version 4. DT 27-MAR-2024, entry version 119. DE RecName: Full=Solute carrier family 12 member 8; DE AltName: Full=Cation-chloride cotransporter 9; GN Name=SLC12A8; Synonyms=CCC9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUSCEPTIBILITY TO PSORIASIS, RP FUNCTION, TISSUE SPECIFICITY, AND VARIANTS CYS-181 AND VAL-281. RX PubMed=11863360; DOI=10.1006/geno.2002.6720; RA Hewett D., Samuelsson L., Polding J., Enlund F., Smart D., Cantone K., RA See C.G., Chadha S., Inerot A., Enerback C., Montgomery D., RA Christodolou C., Robinson P., Matthews P., Plumpton M., Wahlstrom J., RA Swanbeck G., Martinsson T., Roses A., Riley J., Purvis I.; RT "Identification of a psoriasis susceptibility candidate gene by linkage RT disequilibrium mapping with a localized single nucleotide polymorphism RT map."; RL Genomics 79:305-314(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS VAL-281 AND GLN-664. RA Mount D.B.; RT "Characterization of Homo sapiens CCC9, a novel member of the cation- RT chloride cotransporter gene family."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). RC TISSUE=Lung; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Endometrial adenocarcinoma, and Salivary gland; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT RP VAL-281. RC TISSUE=Colon, and Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 407-714 (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [8] RP SUSCEPTIBILITY TO PSORIASIS. RX PubMed=16297188; DOI=10.1111/j.0022-202x.2005.23847.x; RA Hueffmeier U., Lascorz J., Traupe H., Boehm B., Schuermeier-Horst F., RA Staender M., Kelsch R., Baumann C., Kuester W., Burkhardt H., Reis A.; RT "Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a RT role in susceptibility to psoriasis vulgaris."; RL J. Invest. Dermatol. 125:906-912(2005). CC -!- FUNCTION: Cation/chloride cotransporter that may play a role in the CC control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}. CC -!- INTERACTION: CC A0AV02; P26367: PAX6; NbExp=3; IntAct=EBI-11737524, EBI-747278; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=A0AV02-1; Sequence=Displayed; CC Name=2; CC IsoId=A0AV02-2; Sequence=VSP_028330; CC Name=3; CC IsoId=A0AV02-3; Sequence=VSP_028329, VSP_028331; CC Name=4; CC IsoId=A0AV02-4; Sequence=VSP_028328, VSP_028332; CC Name=5; CC IsoId=A0AV02-5; Sequence=VSP_028327; CC -!- TISSUE SPECIFICITY: Ubiquitous with very low level in normal skin. CC {ECO:0000269|PubMed:11863360}. CC -!- DISEASE: Note=SLC12A8 has been identified as a possible susceptibility CC gene for psoriasis mapped to chromosome 3q21 (PSORS5). CC -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH20506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAH63528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAH63528.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAK94307.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAM73657.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAD97969.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF389851; AAK94307.1; ALT_SEQ; Genomic_DNA. DR EMBL; AF390442; AAM73657.1; ALT_INIT; mRNA. DR EMBL; AF345197; AAO49174.1; -; mRNA. DR EMBL; AK026841; BAB15571.1; -; mRNA. DR EMBL; BX538023; CAD97969.1; ALT_INIT; mRNA. DR EMBL; CR749632; CAH18426.1; -; mRNA. DR EMBL; AC055752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC108688; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC117488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC020506; AAH20506.1; ALT_INIT; mRNA. DR EMBL; BC063528; AAH63528.1; ALT_SEQ; mRNA. DR EMBL; BC126158; AAI26159.1; -; mRNA. DR EMBL; BC126160; AAI26161.1; -; mRNA. DR EMBL; CR457363; CAG33644.1; -; mRNA. DR CCDS; CCDS43143.1; -. [A0AV02-1] DR RefSeq; NP_001182412.1; NM_001195483.1. [A0AV02-1] DR RefSeq; NP_078904.3; NM_024628.5. [A0AV02-1] DR AlphaFoldDB; A0AV02; -. DR SMR; A0AV02; -. DR BioGRID; 124140; 15. DR IntAct; A0AV02; 4. DR MINT; A0AV02; -. DR STRING; 9606.ENSP00000377112; -. DR TCDB; 2.A.30.1.7; the cation-chloride cotransporter (ccc) family. DR GlyCosmos; A0AV02; 1 site, No reported glycans. DR GlyGen; A0AV02; 1 site. DR iPTMnet; A0AV02; -. DR PhosphoSitePlus; A0AV02; -. DR SwissPalm; A0AV02; -. DR BioMuta; SLC12A8; -. DR EPD; A0AV02; -. DR jPOST; A0AV02; -. DR MassIVE; A0AV02; -. DR MaxQB; A0AV02; -. DR PaxDb; 9606-ENSP00000377112; -. DR PeptideAtlas; A0AV02; -. DR ProteomicsDB; 10; -. [A0AV02-2] DR ProteomicsDB; 11; -. [A0AV02-3] DR ProteomicsDB; 12; -. [A0AV02-4] DR ProteomicsDB; 13; -. [A0AV02-5] DR ProteomicsDB; 9; -. [A0AV02-1] DR TopDownProteomics; A0AV02-3; -. [A0AV02-3] DR TopDownProteomics; A0AV02-5; -. [A0AV02-5] DR Antibodypedia; 33008; 50 antibodies from 17 providers. DR DNASU; 84561; -. DR Ensembl; ENST00000393469.8; ENSP00000377112.4; ENSG00000221955.11. [A0AV02-1] DR Ensembl; ENST00000430155.6; ENSP00000415713.2; ENSG00000221955.11. [A0AV02-3] DR Ensembl; ENST00000469902.6; ENSP00000418783.1; ENSG00000221955.11. [A0AV02-1] DR GeneID; 84561; -. DR KEGG; hsa:84561; -. DR MANE-Select; ENST00000469902.6; ENSP00000418783.1; NM_024628.6; NP_078904.4. DR UCSC; uc003eht.4; human. [A0AV02-1] DR AGR; HGNC:15595; -. DR CTD; 84561; -. DR DisGeNET; 84561; -. DR GeneCards; SLC12A8; -. DR HGNC; HGNC:15595; SLC12A8. DR HPA; ENSG00000221955; Tissue enhanced (thyroid). DR MIM; 611316; gene. DR neXtProt; NX_A0AV02; -. DR OpenTargets; ENSG00000221955; -. DR PharmGKB; PA37991; -. DR VEuPathDB; HostDB:ENSG00000221955; -. DR eggNOG; KOG2083; Eukaryota. DR GeneTree; ENSGT00940000160130; -. DR HOGENOM; CLU_017440_1_1_1; -. DR InParanoid; A0AV02; -. DR OMA; IMFIIQW; -. DR OrthoDB; 5403154at2759; -. DR TreeFam; TF313191; -. DR PathwayCommons; A0AV02; -. DR SignaLink; A0AV02; -. DR BioGRID-ORCS; 84561; 9 hits in 1142 CRISPR screens. DR ChiTaRS; SLC12A8; human. DR GeneWiki; SLC12A8; -. DR GenomeRNAi; 84561; -. DR Pharos; A0AV02; Tbio. DR PRO; PR:A0AV02; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; A0AV02; Protein. DR Bgee; ENSG00000221955; Expressed in right lobe of thyroid gland and 139 other cell types or tissues. DR ExpressionAtlas; A0AV02; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central. DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central. DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central. DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central. DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central. DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central. DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1. DR InterPro; IPR004841; AA-permease/SLC12A_dom. DR InterPro; IPR004842; SLC12A_fam. DR PANTHER; PTHR11827:SF6; SOLUTE CARRIER FAMILY 12 MEMBER 8; 1. DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1. DR Pfam; PF00324; AA_permease; 1. DR Genevisible; A0AV02; HS. PE 1: Evidence at protein level; KW Alternative splicing; Chloride; Glycoprotein; Ion transport; Membrane; KW Potassium; Potassium transport; Reference proteome; Symport; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..714 FT /note="Solute carrier family 12 member 8" FT /id="PRO_0000305287" FT TRANSMEM 37..60 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 72..93 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 99..116 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 123..142 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 154..173 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 185..205 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 233..254 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 266..289 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 309..331 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 360..377 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 383..403 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 593..616 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 622..643 FT /note="Helical" FT /evidence="ECO:0000255" FT REGION 471..503 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 530..550 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 484..498 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 531..549 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 221 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1..406 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_028327" FT VAR_SEQ 1..247 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_028328" FT VAR_SEQ 1..199 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_028329" FT VAR_SEQ 1..17 FT /note="MTQMSQVQELFHEAAQQ -> MLPLERTITYRDMSSFIQVKNHFNVVNVTCV FT SYRSTCFRDMRRFIL (in isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_028330" FT VAR_SEQ 200..245 FT /note="GSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAAT -> MR FT RAAAGGLAVGQLPGEGPAGEEGAALGKAMRGGGCSPHSPSGCLS (in isoform FT 3)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_028331" FT VAR_SEQ 569..661 FT /note="DFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVN FT MGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCR -> G (in isoform FT 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_028332" FT VARIANT 181 FT /note="R -> C (in dbSNP:rs2993631)" FT /evidence="ECO:0000269|PubMed:11863360" FT /id="VAR_035199" FT VARIANT 266 FT /note="L -> P (in dbSNP:rs863642)" FT /id="VAR_035200" FT VARIANT 281 FT /note="I -> V (in dbSNP:rs621383)" FT /evidence="ECO:0000269|PubMed:11863360, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2" FT /id="VAR_062148" FT VARIANT 541 FT /note="K -> R (in dbSNP:rs6773138)" FT /id="VAR_035201" FT VARIANT 664 FT /note="R -> Q (in dbSNP:rs2981482)" FT /evidence="ECO:0000269|Ref.2" FT /id="VAR_035202" FT CONFLICT 111 FT /note="S -> P (in Ref. 4; CAH18426)" FT /evidence="ECO:0000305" FT CONFLICT 319 FT /note="S -> P (in Ref. 1; AAM73657)" FT /evidence="ECO:0000305" FT CONFLICT 433 FT /note="L -> P (in Ref. 6; CAG33644)" FT /evidence="ECO:0000305" FT CONFLICT 481 FT /note="E -> D (in Ref. 3; BAB15571)" FT /evidence="ECO:0000305" FT CONFLICT 512 FT /note="P -> L (in Ref. 4; CAH18426)" FT /evidence="ECO:0000305" FT CONFLICT 555 FT /note="L -> P (in Ref. 4; CAD97969)" FT /evidence="ECO:0000305" FT CONFLICT 698 FT /note="R -> H (in Ref. 2; AAO49174)" FT /evidence="ECO:0000305" SQ SEQUENCE 714 AA; 78239 MW; CE7669E9758EF00D CRC64; MTQMSQVQEL FHEAAQQDAL AQPQPWWKTQ LFMWEPVLFG TWDGVFTSCM INIFGVVLFL RTGWLVGNTG VLLGMFLVSF VILVALVTVL SGIGVGERSS IGSGGVYSMI SSVLGGQTGG TIGLLYVFGQ CVAGAMYITG FAESISDLLG LGNIWAVRGI SVAVLLALLG INLAGVKWII RLQLLLLFLL AVSTLDFVVG SFTHLDPEHG FIGYSPELLQ NNTLPDYSPG ESFFTVFGVF FPAATGVMAG FNMGGDLREP AASIPLGSLA AVGISWFLYI IFVFLLGAIC TREALRYDFL IAEKVSLMGF LFLLGLYISS LASCMGGLYG APRILQCIAQ EKVIPALACL GQGKGPNKTP VAAICLTSLV TMAFVFVGQV NVLAPIVTIN FMLTYVAVDY SYFSLSMCSC SLTPVPEPVL REGAEGLHCS EHLLLEKAPS YGSEGPAQRV LEGTLLEFTK DMDQLLQLTR KLESSQPRQG EGNRTPESQK RKSKKATKQT LQDSFLLDLK SPPSFPVEIS DRLPAASWEG QESCWNKQTS KSEGTQPEGT YGEQLVPELC NQSESSGEDF FLKSRLQEQD VWRRSTSFYT HMCNPWVSLL GAVGSLLIMF VIQWVYTLVN MGVAAIVYFY IGRASPGLHL GSASNFSFFR WMRSLLLPSC RSLRSPQEQI ILAPSLAKVD MEMTQLTQEN ADFATRDRYH HSSLVNREQL MPHY //