A0AV02 (S12A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 12 member 8

Alternative name(s):
Cation-chloride cotransporter 9

Gene names

Name:	SLC12A8
Synonyms:	CCC9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	714 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitous with very low level in normal skin. Ref.1
Involvement in disease	SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5).
Sequence similarities	Belongs to the SLC12A transporter family.
Sequence caution	The sequence AAH20506.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH63528.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH63528.1 differs from that shown. Reason: Frameshift at position 569. The sequence AAK94307.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAM73657.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD97969.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Chloride Potassium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0AV02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0AV02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTQMSQVQELFHEAAQQ → MLPLERTITYRDMSSFIQVKNHFNVVNVTCVSYRSTCFRDMRRFIL

Note: No experimental confirmation available.

Isoform 3 (identifier: A0AV02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.
     200-245: GSFTHLDPEH...VFGVFFPAAT → MRRAAAGGLA...SPHSPSGCLS

Note: No experimental confirmation available.

Isoform 4 (identifier: A0AV02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.
     569-661: DFFLKSRLQE...MRSLLLPSCR → G

Note: No experimental confirmation available.

Isoform 5 (identifier: A0AV02-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-406: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 714	714	Solute carrier family 12 member 8		PRO_0000305287
Regions
	Transmembrane	37 – 60	24	Helical; Potential
	Transmembrane	72 – 93	22	Helical; Potential
	Transmembrane	99 – 116	18	Helical; Potential
	Transmembrane	123 – 142	20	Helical; Potential
	Transmembrane	154 – 173	20	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	233 – 254	22	Helical; Potential
	Transmembrane	266 – 289	24	Helical; Potential
	Transmembrane	309 – 331	23	Helical; Potential
	Transmembrane	360 – 377	18	Helical; Potential
	Transmembrane	383 – 403	21	Helical; Potential
	Transmembrane	593 – 616	24	Helical; Potential
	Transmembrane	622 – 643	22	Helical; Potential
Amino acid modifications
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 406	406	Missing in isoform 5.		VSP_028327
	Alternative sequence	1 – 247	247	Missing in isoform 4.		VSP_028328
	Alternative sequence	1 – 199	199	Missing in isoform 3.		VSP_028329
	Alternative sequence	1 – 17	17	MTQMS…EAAQQ → MLPLERTITYRDMSSFIQVK NHFNVVNVTCVSYRSTCFRD MRRFIL in isoform 2.		VSP_028330
	Alternative sequence	200 – 245	46	GSFTH…FPAAT → MRRAAAGGLAVGQLPGEGPA GEEGAALGKAMRGGGCSPHS PSGCLS in isoform 3.		VSP_028331
	Alternative sequence	569 – 661	93	DFFLK…LPSCR → G in isoform 4.		VSP_028332
	Natural variant	181	1	R → C. Ref.1 Corresponds to variant rs2993631 [ dbSNP | Ensembl ].		VAR_035199
	Natural variant	266	1	P → L. Corresponds to variant rs863642 [ dbSNP | Ensembl ].		VAR_035200
	Natural variant	281	1	I → V. Ref.1 Ref.2 Ref.6 Corresponds to variant rs621383 [ dbSNP | Ensembl ].		VAR_062148
	Natural variant	541	1	K → R. Corresponds to variant rs6773138 [ dbSNP | Ensembl ].		VAR_035201
	Natural variant	664	1	R → Q. Ref.2 Corresponds to variant rs2981482 [ dbSNP | Ensembl ].		VAR_035202
Experimental info
	Sequence conflict	111	1	S → P in CAH18426. Ref.4
	Sequence conflict	319	1	S → P in AAM73657. Ref.1
	Sequence conflict	433	1	L → P in CAG33644. Ref.6
	Sequence conflict	481	1	E → D in BAB15571. Ref.3
	Sequence conflict	512	1	P → L in CAH18426. Ref.4
	Sequence conflict	555	1	L → P in CAD97969. Ref.4
	Sequence conflict	698	1	R → H in AAO49174. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 9B7C070C2FB04507	FASTA	714	78,223
	10 20 30 40 50 60 MTQMSQVQEL FHEAAQQDAL AQPQPWWKTQ LFMWEPVLFG TWDGVFTSCM INIFGVVLFL 70 80 90 100 110 120 RTGWLVGNTG VLLGMFLVSF VILVALVTVL SGIGVGERSS IGSGGVYSMI SSVLGGQTGG 130 140 150 160 170 180 TIGLLYVFGQ CVAGAMYITG FAESISDLLG LGNIWAVRGI SVAVLLALLG INLAGVKWII 190 200 210 220 230 240 RLQLLLLFLL AVSTLDFVVG SFTHLDPEHG FIGYSPELLQ NNTLPDYSPG ESFFTVFGVF 250 260 270 280 290 300 FPAATGVMAG FNMGGDLREP AASIPPGSLA AVGISWFLYI IFVFLLGAIC TREALRYDFL 310 320 330 340 350 360 IAEKVSLMGF LFLLGLYISS LASCMGGLYG APRILQCIAQ EKVIPALACL GQGKGPNKTP 370 380 390 400 410 420 VAAICLTSLV TMAFVFVGQV NVLAPIVTIN FMLTYVAVDY SYFSLSMCSC SLTPVPEPVL 430 440 450 460 470 480 REGAEGLHCS EHLLLEKAPS YGSEGPAQRV LEGTLLEFTK DMDQLLQLTR KLESSQPRQG 490 500 510 520 530 540 EGNRTPESQK RKSKKATKQT LQDSFLLDLK SPPSFPVEIS DRLPAASWEG QESCWNKQTS 550 560 570 580 590 600 KSEGTQPEGT YGEQLVPELC NQSESSGEDF FLKSRLQEQD VWRRSTSFYT HMCNPWVSLL 610 620 630 640 650 660 GAVGSLLIMF VIQWVYTLVN MGVAAIVYFY IGRASPGLHL GSASNFSFFR WMRSLLLPSC 670 680 690 700 710 RSLRSPQEQI ILAPSLAKVD MEMTQLTQEN ADFATRDRYH HSSLVNREQL MPHY
	Isoform 2 [UniParc]. Checksum: 1707569985931744	FASTA	743	81,806
	10 20 30 40 50 60 MLPLERTITY RDMSSFIQVK NHFNVVNVTC VSYRSTCFRD MRRFILDALA QPQPWWKTQL 70 80 90 100 110 120 FMWEPVLFGT WDGVFTSCMI NIFGVVLFLR TGWLVGNTGV LLGMFLVSFV ILVALVTVLS 130 140 150 160 170 180 GIGVGERSSI GSGGVYSMIS SVLGGQTGGT IGLLYVFGQC VAGAMYITGF AESISDLLGL 190 200 210 220 230 240 GNIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLFLLA VSTLDFVVGS FTHLDPEHGF 250 260 270 280 290 300 IGYSPELLQN NTLPDYSPGE SFFTVFGVFF PAATGVMAGF NMGGDLREPA ASIPPGSLAA 310 320 330 340 350 360 VGISWFLYII FVFLLGAICT REALRYDFLI AEKVSLMGFL FLLGLYISSL ASCMGGLYGA 370 380 390 400 410 420 PRILQCIAQE KVIPALACLG QGKGPNKTPV AAICLTSLVT MAFVFVGQVN VLAPIVTINF 430 440 450 460 470 480 MLTYVAVDYS YFSLSMCSCS LTPVPEPVLR EGAEGLHCSE HLLLEKAPSY GSEGPAQRVL 490 500 510 520 530 540 EGTLLEFTKD MDQLLQLTRK LESSQPRQGE GNRTPESQKR KSKKATKQTL QDSFLLDLKS 550 560 570 580 590 600 PPSFPVEISD RLPAASWEGQ ESCWNKQTSK SEGTQPEGTY GEQLVPELCN QSESSGEDFF 610 620 630 640 650 660 LKSRLQEQDV WRRSTSFYTH MCNPWVSLLG AVGSLLIMFV IQWVYTLVNM GVAAIVYFYI 670 680 690 700 710 720 GRASPGLHLG SASNFSFFRW MRSLLLPSCR SLRSPQEQII LAPSLAKVDM EMTQLTQENA 730 740 DFATRDRYHH SSLVNREQLM PHY
	Isoform 3 [UniParc]. Checksum: 6107608E3AA3990C	FASTA	515	56,160
	10 20 30 40 50 60 MRRAAAGGLA VGQLPGEGPA GEEGAALGKA MRGGGCSPHS PSGCLSGVMA GFNMGGDLRE 70 80 90 100 110 120 PAASIPPGSL AAVGISWFLY IIFVFLLGAI CTREALRYDF LIAEKVSLMG FLFLLGLYIS 130 140 150 160 170 180 SLASCMGGLY GAPRILQCIA QEKVIPALAC LGQGKGPNKT PVAAICLTSL VTMAFVFVGQ 190 200 210 220 230 240 VNVLAPIVTI NFMLTYVAVD YSYFSLSMCS CSLTPVPEPV LREGAEGLHC SEHLLLEKAP 250 260 270 280 290 300 SYGSEGPAQR VLEGTLLEFT KDMDQLLQLT RKLESSQPRQ GEGNRTPESQ KRKSKKATKQ 310 320 330 340 350 360 TLQDSFLLDL KSPPSFPVEI SDRLPAASWE GQESCWNKQT SKSEGTQPEG TYGEQLVPEL 370 380 390 400 410 420 CNQSESSGED FFLKSRLQEQ DVWRRSTSFY THMCNPWVSL LGAVGSLLIM FVIQWVYTLV 430 440 450 460 470 480 NMGVAAIVYF YIGRASPGLH LGSASNFSFF RWMRSLLLPS CRSLRSPQEQ IILAPSLAKV 490 500 510 DMEMTQLTQE NADFATRDRY HHSSLVNREQ LMPHY
	Isoform 4 [UniParc]. Checksum: BFE78B167C8FEB09	FASTA	375	41,059
	10 20 30 40 50 60 MAGFNMGGDL REPAASIPPG SLAAVGISWF LYIIFVFLLG AICTREALRY DFLIAEKVSL 70 80 90 100 110 120 MGFLFLLGLY ISSLASCMGG LYGAPRILQC IAQEKVIPAL ACLGQGKGPN KTPVAAICLT 130 140 150 160 170 180 SLVTMAFVFV GQVNVLAPIV TINFMLTYVA VDYSYFSLSM CSCSLTPVPE PVLREGAEGL 190 200 210 220 230 240 HCSEHLLLEK APSYGSEGPA QRVLEGTLLE FTKDMDQLLQ LTRKLESSQP RQGEGNRTPE 250 260 270 280 290 300 SQKRKSKKAT KQTLQDSFLL DLKSPPSFPV EISDRLPAAS WEGQESCWNK QTSKSEGTQP 310 320 330 340 350 360 EGTYGEQLVP ELCNQSESSG EGSLRSPQEQ IILAPSLAKV DMEMTQLTQE NADFATRDRY 370 HHSSLVNREQ LMPHY
	Isoform 5 [UniParc]. Checksum: AF232C6971B2A80C	FASTA	308	34,799
	10 20 30 40 50 60 MCSCSLTPVP EPVLREGAEG LHCSEHLLLE KAPSYGSEGP AQRVLEGTLL EFTKDMDQLL 70 80 90 100 110 120 QLTRKLESSQ PRQGEGNRTP ESQKRKSKKA TKQTLQDSFL LDLKSPPSFP VEISDRLPAA 130 140 150 160 170 180 SWEGQESCWN KQTSKSEGTQ PEGTYGEQLV PELCNQSESS GEDFFLKSRL QEQDVWRRST 190 200 210 220 230 240 SFYTHMCNPW VSLLGAVGSL LIMFVIQWVY TLVNMGVAAI VYFYIGRASP GLHLGSASNF 250 260 270 280 290 300 SFFRWMRSLL LPSCRSLRSP QEQIILAPSL AKVDMEMTQL TQENADFATR DRYHHSSLVN REQLMPHY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map." Hewett D., Samuelsson L., Polding J., Enlund F., Smart D., Cantone K., See C.G., Chadha S., Inerot A., Enerback C., Montgomery D., Christodolou C., Robinson P., Matthews P., Plumpton M., Wahlstrom J., Swanbeck G., Martinsson T. , Roses A., Riley J., Purvis I. Genomics 79:305-314(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUSCEPTIBILITY TO PSORIASIS, FUNCTION, TISSUE SPECIFICITY, VARIANTS CYS-181 AND VAL-281.
[2]	"Characterization of Homo sapiens CCC9, a novel member of the cation-chloride cotransporter gene family." Mount D.B. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-281 AND GLN-664.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Lung.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Endometrial adenocarcinoma and Salivary gland.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT VAL-281. Tissue: Colon and Lymph.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 407-714 (ISOFORM 1).
[8]	"Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris." Hueffmeier U., Lascorz J., Traupe H., Boehm B., Schuermeier-Horst F., Staender M., Kelsch R., Baumann C., Kuester W., Burkhardt H., Reis A. J. Invest. Dermatol. 125:906-912(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUSCEPTIBILITY TO PSORIASIS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF389851 Genomic DNA. Translation: AAK94307.1. Sequence problems. AF390442 mRNA. Translation: AAM73657.1. Different initiation. AF345197 mRNA. Translation: AAO49174.1. AK026841 mRNA. Translation: BAB15571.1. BX538023 mRNA. Translation: CAD97969.1. Different initiation. CR749632 mRNA. Translation: CAH18426.1. AC055752 Genomic DNA. No translation available. AC108688 Genomic DNA. No translation available. AC117488 Genomic DNA. No translation available. BC020506 mRNA. Translation: AAH20506.1. Different initiation. BC063528 mRNA. Translation: AAH63528.1. Sequence problems. BC126158 mRNA. Translation: AAI26159.1. BC126160 mRNA. Translation: AAI26161.1. CR457363 mRNA. Translation: CAG33644.1.
IPI	IPI00793608. IPI00855723. IPI00867607. IPI00867726. IPI00867740.
RefSeq	NP_001182412.1. NM_001195483.1. NP_078904.3. NM_024628.5.
UniGene	Hs.658514.
3D structure databases
ProteinModelPortal	A0AV02.
ModBase	Search...
PTM databases
PhosphoSite	A0AV02.
Proteomic databases
PaxDb	A0AV02.
PRIDE	A0AV02.
Protocols and materials databases
DNASU	84561.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393469; ENSP00000377112; ENSG00000221955. ENST00000423114; ENSP00000404243; ENSG00000221955. ENST00000430155; ENSP00000415713; ENSG00000221955. ENST00000469902; ENSP00000418783; ENSG00000221955.
GeneID	84561.
KEGG	hsa:84561.
UCSC	uc003eht.4. human. uc003ehv.4. human. uc003ehw.4. human.
Organism-specific databases
CTD	84561.
GeneCards	GC03M124832.
HGNC	HGNC:15595. SLC12A8.
HPA	HPA031123.
MIM	611316. gene.
neXtProt	NX_A0AV02.
PharmGKB	PA37991.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0531.
HOVERGEN	HBG108430.
InParanoid	A0AV02.
KO	K14428.
OMA	GRGPNKV.
OrthoDB	EOG4X0MS2.
PhylomeDB	A0AV02.
Gene expression databases
ArrayExpress	A0AV02.
Bgee	A0AV02.
Genevestigator	A0AV02.
Family and domain databases
InterPro	IPR004841. AA-permease_dom. [Graphical view]
Pfam	PF00324. AA_permease. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC12A8. human.
GenomeRNAi	84561.
NextBio	74454.
SOURCE	Search...

Entry information

Entry name

S12A8_HUMAN

Accession

Primary (citable) accession number: A0AV02
Secondary accession number(s): C9JJJ2 , Q68D04, Q6I9Z2, Q6P4C0, Q7Z3A6, Q86WK0, Q8NFX9, Q8WUI3, Q96RF9, Q9H5P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.