ID KAL1L_HUMAN Reviewed; 987 AA. AC A0AUZ9; B7ZLN1; I6L9A8; Q53TV8; Q53TW3; Q6IS05; Q8TCI1; Q96MI0; Q9UFC3; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 26-FEB-2008, sequence version 2. DT 27-MAR-2024, entry version 117. DE RecName: Full=KAT8 regulatory NSL complex subunit 1-like protein; DE AltName: Full=MSL1v2; GN Name=KANSL1L; Synonyms=C2orf67; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Lung, and Prostate; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 307-987 (ISOFORM 4). RC TISSUE=Brain, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 532-987 (ISOFORM 1). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-859, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [7] RP ACETYLATION BY KAT8, AND DEACETYLATION BY HDAC3. RX PubMed=24145748; DOI=10.3390/ijms141020966; RA Chu Y.L., Wu X., Xu J., Watts J.L., Her C.; RT "DNA damage induced MutS homologue hMSH4 acetylation."; RL Int. J. Mol. Sci. 14:20966-20982(2013). RN [8] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-134, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=A0AUZ9-1; Sequence=Displayed; CC Name=2; CC IsoId=A0AUZ9-2; Sequence=VSP_031499; CC Name=3; CC IsoId=A0AUZ9-3; Sequence=VSP_031500, VSP_031501; CC Name=4; CC IsoId=A0AUZ9-4; Sequence=VSP_031497, VSP_031498; CC -!- PTM: Acetylated on lysine residues by KAT8 upon ionizing radiation- CC induced DNA damage; deacetylated by HDAC3. CC {ECO:0000269|PubMed:24145748}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB85085.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAB85085.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC Sequence=BAB85085.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK056911; BAB71308.1; -; mRNA. DR EMBL; AK074441; BAB85085.1; ALT_SEQ; mRNA. DR EMBL; AC006994; AAY14880.1; -; Genomic_DNA. DR EMBL; AC007038; AAX93088.1; -; Genomic_DNA. DR EMBL; CH471063; EAW70479.1; -; Genomic_DNA. DR EMBL; BC032837; AAH32837.1; -; mRNA. DR EMBL; BC070141; AAH70141.1; -; mRNA. DR EMBL; BC126155; AAI26156.1; -; mRNA. DR EMBL; BC143914; AAI43915.1; -; mRNA. DR EMBL; AL133053; CAB61379.1; -; mRNA. DR CCDS; CCDS33370.1; -. [A0AUZ9-1] DR CCDS; CCDS77519.1; -. [A0AUZ9-2] DR PIR; T42655; T42655. DR RefSeq; NP_001294905.1; NM_001307976.1. [A0AUZ9-2] DR RefSeq; NP_689732.2; NM_152519.3. [A0AUZ9-1] DR RefSeq; XP_005246386.1; XM_005246329.4. [A0AUZ9-1] DR RefSeq; XP_005246387.1; XM_005246330.4. [A0AUZ9-1] DR RefSeq; XP_011509008.1; XM_011510706.2. [A0AUZ9-1] DR RefSeq; XP_011509009.1; XM_011510707.2. DR RefSeq; XP_016858919.1; XM_017003430.1. [A0AUZ9-1] DR AlphaFoldDB; A0AUZ9; -. DR SMR; A0AUZ9; -. DR BioGRID; 127340; 4. DR IntAct; A0AUZ9; 2. DR STRING; 9606.ENSP00000281772; -. DR iPTMnet; A0AUZ9; -. DR PhosphoSitePlus; A0AUZ9; -. DR BioMuta; KANSL1L; -. DR EPD; A0AUZ9; -. DR jPOST; A0AUZ9; -. DR MassIVE; A0AUZ9; -. DR PaxDb; 9606-ENSP00000281772; -. DR PeptideAtlas; A0AUZ9; -. DR ProteomicsDB; 5; -. [A0AUZ9-1] DR ProteomicsDB; 6; -. [A0AUZ9-2] DR ProteomicsDB; 7; -. [A0AUZ9-3] DR ProteomicsDB; 8; -. [A0AUZ9-4] DR Antibodypedia; 63309; 57 antibodies from 13 providers. DR DNASU; 151050; -. DR Ensembl; ENST00000281772.14; ENSP00000281772.8; ENSG00000144445.17. [A0AUZ9-1] DR Ensembl; ENST00000418791.5; ENSP00000405724.1; ENSG00000144445.17. [A0AUZ9-2] DR Ensembl; ENST00000452086.5; ENSP00000401408.1; ENSG00000144445.17. [A0AUZ9-3] DR Ensembl; ENST00000457374.5; ENSP00000393432.1; ENSG00000144445.17. [A0AUZ9-3] DR GeneID; 151050; -. DR KEGG; hsa:151050; -. DR MANE-Select; ENST00000281772.14; ENSP00000281772.8; NM_152519.4; NP_689732.2. DR UCSC; uc002vds.4; human. [A0AUZ9-1] DR AGR; HGNC:26310; -. DR CTD; 151050; -. DR DisGeNET; 151050; -. DR GeneCards; KANSL1L; -. DR HGNC; HGNC:26310; KANSL1L. DR HPA; ENSG00000144445; Tissue enriched (parathyroid). DR MIM; 613833; gene. DR neXtProt; NX_A0AUZ9; -. DR OpenTargets; ENSG00000144445; -. DR PharmGKB; PA162379439; -. DR VEuPathDB; HostDB:ENSG00000144445; -. DR eggNOG; ENOG502QRI7; Eukaryota. DR GeneTree; ENSGT00530000063688; -. DR HOGENOM; CLU_011035_1_0_1; -. DR InParanoid; A0AUZ9; -. DR OMA; WRVVDIQ; -. DR OrthoDB; 5359304at2759; -. DR PhylomeDB; A0AUZ9; -. DR TreeFam; TF336511; -. DR PathwayCommons; A0AUZ9; -. DR SignaLink; A0AUZ9; -. DR BioGRID-ORCS; 151050; 12 hits in 1161 CRISPR screens. DR ChiTaRS; KANSL1L; human. DR GenomeRNAi; 151050; -. DR Pharos; A0AUZ9; Tdark. DR PRO; PR:A0AUZ9; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; A0AUZ9; Protein. DR Bgee; ENSG00000144445; Expressed in calcaneal tendon and 178 other cell types or tissues. DR ExpressionAtlas; A0AUZ9; baseline and differential. DR GO; GO:0044545; C:NSL complex; IBA:GO_Central. DR GO; GO:0035035; F:histone acetyltransferase binding; IBA:GO_Central. DR Gene3D; 6.10.250.3170; -; 1. DR InterPro; IPR026180; NSL1. DR InterPro; IPR029332; PEHE_dom. DR PANTHER; PTHR22443:SF16; KAT8 REGULATORY NSL COMPLEX SUBUNIT 1-LIKE PROTEIN; 1. DR PANTHER; PTHR22443; NON-SPECIFIC LETHAL 1, ISOFORM M; 1. DR Pfam; PF15275; PEHE; 1. DR SMART; SM01300; PEHE; 1. DR Genevisible; A0AUZ9; HS. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Isopeptide bond; Phosphoprotein; KW Reference proteome; Ubl conjugation. FT CHAIN 1..987 FT /note="KAT8 regulatory NSL complex subunit 1-like protein" FT /id="PRO_0000319582" FT REGION 708..738 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 949..972 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 708..732 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 462 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q5DTI6" FT MOD_RES 859 FT /note="N6-acetyllysine" FT /evidence="ECO:0007744|PubMed:19608861" FT CROSSLNK 134 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 641..648 FT /note="DVPLHFHF -> GKPPCNNF (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031497" FT VAR_SEQ 649..987 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031498" FT VAR_SEQ 677..718 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_031499" FT VAR_SEQ 677..705 FT /note="VHSTLNQWRNGYSPICKPQIRSESSAQLL -> GMSHLQFLYSICLFMSLYL FT LFLHSKKNKI (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_031500" FT VAR_SEQ 706..987 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_031501" FT CONFLICT 401 FT /note="D -> G (in Ref. 1; BAB71308)" FT /evidence="ECO:0000305" FT CONFLICT 458 FT /note="D -> G (in Ref. 1; BAB71308)" FT /evidence="ECO:0000305" FT CONFLICT 471 FT /note="R -> G (in Ref. 1; BAB85085)" FT /evidence="ECO:0000305" FT CONFLICT 501 FT /note="S -> F (in Ref. 1; BAB85085)" FT /evidence="ECO:0000305" FT CONFLICT 587 FT /note="L -> W (in Ref. 5; CAB61379)" FT /evidence="ECO:0000305" FT CONFLICT 606 FT /note="A -> T (in Ref. 1; BAB71308)" FT /evidence="ECO:0000305" FT CONFLICT 756 FT /note="S -> I (in Ref. 1; BAB85085)" FT /evidence="ECO:0000305" FT CONFLICT 848 FT /note="K -> Q (in Ref. 1; BAB85085)" FT /evidence="ECO:0000305" SQ SEQUENCE 987 AA; 112253 MW; FAAF236C850E6254 CRC64; MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR //