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A0AUZ9

- KAL1L_HUMAN

UniProt

A0AUZ9 - KAL1L_HUMAN

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Protein

KAT8 regulatory NSL complex subunit 1-like protein

Gene
KANSL1L, C2orf67
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 1-like protein
Alternative name(s):
MSL1v2
Gene namesi
Name:KANSL1L
Synonyms:C2orf67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26310. KANSL1L.

Subcellular locationi

GO - Cellular componenti

  1. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 987987KAT8 regulatory NSL complex subunit 1-like proteinPRO_0000319582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei859 – 8591N6-acetyllysine1 Publication

Post-translational modificationi

Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA0AUZ9.
PRIDEiA0AUZ9.

PTM databases

PhosphoSiteiA0AUZ9.

Expressioni

Gene expression databases

ArrayExpressiA0AUZ9.
BgeeiA0AUZ9.
CleanExiHS_C2orf67.
GenevestigatoriA0AUZ9.

Organism-specific databases

HPAiHPA043102.
HPA046790.

Interactioni

Protein-protein interaction databases

BioGridi127340. 1 interaction.
IntActiA0AUZ9. 1 interaction.
STRINGi9606.ENSP00000281772.

Structurei

3D structure databases

ProteinModelPortaliA0AUZ9.
SMRiA0AUZ9. Positions 796-841.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG85593.
HOVERGENiHBG107580.
InParanoidiA0AUZ9.
OMAiVNCSTEW.
OrthoDBiEOG7VQJF6.
PhylomeDBiA0AUZ9.
TreeFamiTF336511.

Family and domain databases

InterProiIPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view]
PANTHERiPTHR22443. PTHR22443. 1 hit.
PfamiPF15275. PEHE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0AUZ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG    50
FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK 100
LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ 150
IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI 200
VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA 250
KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT 300
AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD 350
DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT 400
DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC 450
QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL 500
SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS 550
SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM 600
PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET 650
LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES 700
SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS 750
RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW 800
RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH 850
RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG 900
LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE 950
IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR 987
Length:987
Mass (Da):112,253
Last modified:February 26, 2008 - v2
Checksum:iFAAF236C850E6254
GO
Isoform 2 (identifier: A0AUZ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-718: Missing.

Show »
Length:945
Mass (Da):107,452
Checksum:i601547FF92939BA6
GO
Isoform 3 (identifier: A0AUZ9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-705: VHSTLNQWRNGYSPICKPQIRSESSAQLL → GMSHLQFLYSICLFMSLYLLFLHSKKNKI
     706-987: Missing.

Show »
Length:705
Mass (Da):79,988
Checksum:iAFB81C92AEC5238E
GO
Isoform 4 (identifier: A0AUZ9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-648: DVPLHFHF → GKPPCNNF
     649-987: Missing.

Note: No experimental confirmation available.

Show »
Length:648
Mass (Da):73,235
Checksum:iEB01EB1EF725D095
GO

Sequence cautioni

The sequence BAB85085.1 differs from that shown. Reason: Frameshift at positions 496, 502, 550, 553, 673, 676, 755, 757 and 853.
The sequence BAB85085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB85085.1 differs from that shown. Reason: Erroneous termination at position 914. Translated as Trp.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei641 – 6488DVPLHFHF → GKPPCNNF in isoform 4. VSP_031497
Alternative sequencei649 – 987339Missing in isoform 4. VSP_031498Add
BLAST
Alternative sequencei677 – 71842Missing in isoform 2. VSP_031499Add
BLAST
Alternative sequencei677 – 70529VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3. VSP_031500Add
BLAST
Alternative sequencei706 – 987282Missing in isoform 3. VSP_031501Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011D → G in BAB71308. 1 Publication
Sequence conflicti458 – 4581D → G in BAB71308. 1 Publication
Sequence conflicti471 – 4711R → G in BAB85085. 1 Publication
Sequence conflicti501 – 5011S → F in BAB85085. 1 Publication
Sequence conflicti587 – 5871L → W in CAB61379. 1 Publication
Sequence conflicti606 – 6061A → T in BAB71308. 1 Publication
Sequence conflicti756 – 7561S → I in BAB85085. 1 Publication
Sequence conflicti848 – 8481K → Q in BAB85085. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056911 mRNA. Translation: BAB71308.1.
AK074441 mRNA. Translation: BAB85085.1. Sequence problems.
AC006994 Genomic DNA. Translation: AAY14880.1.
AC007038 Genomic DNA. Translation: AAX93088.1.
CH471063 Genomic DNA. Translation: EAW70479.1.
BC032837 mRNA. Translation: AAH32837.1.
BC070141 mRNA. Translation: AAH70141.1.
BC126155 mRNA. Translation: AAI26156.1.
BC143914 mRNA. Translation: AAI43915.1.
AL133053 mRNA. Translation: CAB61379.1.
CCDSiCCDS33370.1. [A0AUZ9-1]
PIRiT42655.
RefSeqiNP_689732.2. NM_152519.2. [A0AUZ9-1]
XP_005246386.1. XM_005246329.2. [A0AUZ9-1]
XP_005246387.1. XM_005246330.2. [A0AUZ9-1]
XP_005246390.1. XM_005246333.2. [A0AUZ9-2]
XP_006712382.1. XM_006712319.1. [A0AUZ9-1]
UniGeneiHs.282260.
Hs.591638.

Genome annotation databases

EnsembliENST00000281772; ENSP00000281772; ENSG00000144445. [A0AUZ9-1]
ENST00000418791; ENSP00000405724; ENSG00000144445. [A0AUZ9-2]
ENST00000452086; ENSP00000401408; ENSG00000144445. [A0AUZ9-3]
ENST00000457374; ENSP00000393432; ENSG00000144445. [A0AUZ9-3]
GeneIDi151050.
KEGGihsa:151050.
UCSCiuc002vds.3. human. [A0AUZ9-1]
uc002vdt.3. human. [A0AUZ9-2]
uc002vdv.3. human.
uc002vdx.1. human. [A0AUZ9-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056911 mRNA. Translation: BAB71308.1 .
AK074441 mRNA. Translation: BAB85085.1 . Sequence problems.
AC006994 Genomic DNA. Translation: AAY14880.1 .
AC007038 Genomic DNA. Translation: AAX93088.1 .
CH471063 Genomic DNA. Translation: EAW70479.1 .
BC032837 mRNA. Translation: AAH32837.1 .
BC070141 mRNA. Translation: AAH70141.1 .
BC126155 mRNA. Translation: AAI26156.1 .
BC143914 mRNA. Translation: AAI43915.1 .
AL133053 mRNA. Translation: CAB61379.1 .
CCDSi CCDS33370.1. [A0AUZ9-1 ]
PIRi T42655.
RefSeqi NP_689732.2. NM_152519.2. [A0AUZ9-1 ]
XP_005246386.1. XM_005246329.2. [A0AUZ9-1 ]
XP_005246387.1. XM_005246330.2. [A0AUZ9-1 ]
XP_005246390.1. XM_005246333.2. [A0AUZ9-2 ]
XP_006712382.1. XM_006712319.1. [A0AUZ9-1 ]
UniGenei Hs.282260.
Hs.591638.

3D structure databases

ProteinModelPortali A0AUZ9.
SMRi A0AUZ9. Positions 796-841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127340. 1 interaction.
IntActi A0AUZ9. 1 interaction.
STRINGi 9606.ENSP00000281772.

PTM databases

PhosphoSitei A0AUZ9.

Proteomic databases

PaxDbi A0AUZ9.
PRIDEi A0AUZ9.

Protocols and materials databases

DNASUi 151050.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281772 ; ENSP00000281772 ; ENSG00000144445 . [A0AUZ9-1 ]
ENST00000418791 ; ENSP00000405724 ; ENSG00000144445 . [A0AUZ9-2 ]
ENST00000452086 ; ENSP00000401408 ; ENSG00000144445 . [A0AUZ9-3 ]
ENST00000457374 ; ENSP00000393432 ; ENSG00000144445 . [A0AUZ9-3 ]
GeneIDi 151050.
KEGGi hsa:151050.
UCSCi uc002vds.3. human. [A0AUZ9-1 ]
uc002vdt.3. human. [A0AUZ9-2 ]
uc002vdv.3. human.
uc002vdx.1. human. [A0AUZ9-4 ]

Organism-specific databases

CTDi 151050.
GeneCardsi GC02M210886.
H-InvDB HIX0161858.
HGNCi HGNC:26310. KANSL1L.
HPAi HPA043102.
HPA046790.
MIMi 613833. gene.
neXtProti NX_A0AUZ9.
PharmGKBi PA162379439.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85593.
HOVERGENi HBG107580.
InParanoidi A0AUZ9.
OMAi VNCSTEW.
OrthoDBi EOG7VQJF6.
PhylomeDBi A0AUZ9.
TreeFami TF336511.

Miscellaneous databases

GenomeRNAii 151050.
NextBioi 35533880.
PROi A0AUZ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi A0AUZ9.
Bgeei A0AUZ9.
CleanExi HS_C2orf67.
Genevestigatori A0AUZ9.

Family and domain databases

InterProi IPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view ]
PANTHERi PTHR22443. PTHR22443. 1 hit.
Pfami PF15275. PEHE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung and Prostate.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-987 (ISOFORM 4).
    Tissue: Brain and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 532-987 (ISOFORM 1).
    Tissue: Testis.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-859, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "DNA damage induced MutS homologue hMSH4 acetylation."
    Chu Y.L., Wu X., Xu J., Watts J.L., Her C.
    Int. J. Mol. Sci. 14:20966-20982(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION BY KAT8, DEACETYLATION BY HDAC3.

Entry informationi

Entry nameiKAL1L_HUMAN
AccessioniPrimary (citable) accession number: A0AUZ9
Secondary accession number(s): B7ZLN1
, I6L9A8, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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