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A0AUZ9 (KAL1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KAT8 regulatory NSL complex subunit 1-like protein
Alternative name(s):
MSL1v2
Gene names
Name:KANSL1L
Synonyms:C2orf67
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length987 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAB85085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB85085.1 differs from that shown. Reason: Erroneous termination at position 914. Translated as Trp.

The sequence BAB85085.1 differs from that shown. Reason: Frameshift at positions 496, 502, 550, 553, 673, 676, 755, 757 and 853.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthistone acetyltransferase complex

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A0AUZ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A0AUZ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     677-718: Missing.
Isoform 3 (identifier: A0AUZ9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     677-705: VHSTLNQWRNGYSPICKPQIRSESSAQLL → GMSHLQFLYSICLFMSLYLLFLHSKKNKI
     706-987: Missing.
Isoform 4 (identifier: A0AUZ9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     641-648: DVPLHFHF → GKPPCNNF
     649-987: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 987987KAT8 regulatory NSL complex subunit 1-like protein
PRO_0000319582

Amino acid modifications

Modified residue8591N6-acetyllysine Ref.6

Natural variations

Alternative sequence641 – 6488DVPLHFHF → GKPPCNNF in isoform 4.
VSP_031497
Alternative sequence649 – 987339Missing in isoform 4.
VSP_031498
Alternative sequence677 – 71842Missing in isoform 2.
VSP_031499
Alternative sequence677 – 70529VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3.
VSP_031500
Alternative sequence706 – 987282Missing in isoform 3.
VSP_031501

Experimental info

Sequence conflict4011D → G in BAB71308. Ref.1
Sequence conflict4581D → G in BAB71308. Ref.1
Sequence conflict4711R → G in BAB85085. Ref.1
Sequence conflict5011S → F in BAB85085. Ref.1
Sequence conflict5871L → W in CAB61379. Ref.5
Sequence conflict6061A → T in BAB71308. Ref.1
Sequence conflict7561S → I in BAB85085. Ref.1
Sequence conflict8481K → Q in BAB85085. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: FAAF236C850E6254

FASTA987112,253
        10         20         30         40         50         60 
MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG FPTPEPTLNT 

        70         80         90        100        110        120 
NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK LGEPSCNKLK NILYNGSNIQ 

       130        140        150        160        170        180 
LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ IILDSNITKD TNVDKVQLQN CKWYQENALL 

       190        200        210        220        230        240 
DKVTDAEIKK GLLHCTQKKI VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR 

       250        260        270        280        290        300 
TQKHLQMLLA KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT 

       310        320        330        340        350        360 
AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD DLDEYTLRKN 

       370        380        390        400        410        420 
VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT DIHRQIRASK GIVVLEECQL 

       430        440        450        460        470        480 
PKDILKKQMQ FADQAASLNI LGNPQVPQEC QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL 

       490        500        510        520        530        540 
TEIINSLIAP LNLSPTSSPL SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK 

       550        560        570        580        590        600 
KRKDRTRLKS SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM 

       610        620        630        640        650        660 
PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET LLKKTEIKGN 

       670        680        690        700        710        720 
LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES SAQLLQGRKK RHLSETALGE 

       730        740        750        760        770        780 
RTKLEESDFQ HTESGSHSNF TAVSNVNVLS RIQNSSRNTA RRRLRSESSY DIDNIVIPMS 

       790        800        810        820        830        840 
LVAPAKLEKL QYKEILTPSW RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR 

       850        860        870        880        890        900 
WSLWEQSKWH RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG 

       910        920        930        940        950        960 
LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE IFGTSVPENG 

       970        980 
HHPKKQSDGM EEYKTFGLGL TNVKKNR 

« Hide

Isoform 2 [UniParc].

Checksum: 601547FF92939BA6
Show »

FASTA945107,452
Isoform 3 [UniParc].

Checksum: AFB81C92AEC5238E
Show »

FASTA70579,988
Isoform 4 [UniParc].

Checksum: EB01EB1EF725D095
Show »

FASTA64873,235

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Lung and Prostate.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-987 (ISOFORM 4).
Tissue: Brain and Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 532-987 (ISOFORM 1).
Tissue: Testis.
[6]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-859, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056911 mRNA. Translation: BAB71308.1.
AK074441 mRNA. Translation: BAB85085.1. Sequence problems.
AC006994 Genomic DNA. Translation: AAY14880.1.
AC007038 Genomic DNA. Translation: AAX93088.1.
CH471063 Genomic DNA. Translation: EAW70479.1.
BC032837 mRNA. Translation: AAH32837.1.
BC070141 mRNA. Translation: AAH70141.1.
BC126155 mRNA. Translation: AAI26156.1.
BC143914 mRNA. Translation: AAI43915.1.
AL133053 mRNA. Translation: CAB61379.1.
PIRT42655.
RefSeqNP_689732.2. NM_152519.2.
XP_005246386.1. XM_005246329.2.
XP_005246387.1. XM_005246330.2.
XP_005246390.1. XM_005246333.2.
UniGeneHs.282260.
Hs.591638.

3D structure databases

ProteinModelPortalA0AUZ9.
SMRA0AUZ9. Positions 796-841.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127340. 1 interaction.
IntActA0AUZ9. 1 interaction.
STRING9606.ENSP00000281772.

PTM databases

PhosphoSiteA0AUZ9.

Proteomic databases

PaxDbA0AUZ9.
PRIDEA0AUZ9.

Protocols and materials databases

DNASU151050.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281772; ENSP00000281772; ENSG00000144445. [A0AUZ9-1]
ENST00000418791; ENSP00000405724; ENSG00000144445. [A0AUZ9-2]
ENST00000452086; ENSP00000401408; ENSG00000144445. [A0AUZ9-3]
ENST00000457374; ENSP00000393432; ENSG00000144445. [A0AUZ9-3]
GeneID151050.
KEGGhsa:151050.
UCSCuc002vds.3. human. [A0AUZ9-1]
uc002vdt.3. human. [A0AUZ9-2]
uc002vdx.1. human. [A0AUZ9-4]

Organism-specific databases

CTD151050.
GeneCardsGC02M210886.
H-InvDBHIX0161858.
HGNCHGNC:26310. KANSL1L.
HPAHPA043102.
HPA046790.
MIM613833. gene.
neXtProtNX_A0AUZ9.
PharmGKBPA162379439.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85593.
HOVERGENHBG107580.
InParanoidA0AUZ9.
OMAVNCSTEW.
OrthoDBEOG7VQJF6.
PhylomeDBA0AUZ9.
TreeFamTF336511.

Gene expression databases

ArrayExpressA0AUZ9.
BgeeA0AUZ9.
CleanExHS_C2orf67.
GenevestigatorA0AUZ9.

Family and domain databases

InterProIPR026180. NSL1.
[Graphical view]
PANTHERPTHR22443. PTHR22443. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi151050.
NextBio86580.
PROA0AUZ9.
SOURCESearch...

Entry information

Entry nameKAL1L_HUMAN
AccessionPrimary (citable) accession number: A0AUZ9
Secondary accession number(s): B7ZLN1 expand/collapse secondary AC list , I6L9A8, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM