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Protein

KAT8 regulatory NSL complex subunit 1-like protein

Gene

KANSL1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 1-like protein
Alternative name(s):
MSL1v2
Gene namesi
Name:KANSL1L
Synonyms:C2orf67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144445.16
HGNCiHGNC:26310 KANSL1L
MIMi613833 gene
neXtProtiNX_A0AUZ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144445
PharmGKBiPA162379439

Polymorphism and mutation databases

BioMutaiKANSL1L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195821 – 987KAT8 regulatory NSL complex subunit 1-like proteinAdd BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei462PhosphoserineBy similarity1
Modified residuei859N6-acetyllysineCombined sources1

Post-translational modificationi

Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA0AUZ9
PaxDbiA0AUZ9
PRIDEiA0AUZ9
ProteomicsDBi5
6 [A0AUZ9-2]
7 [A0AUZ9-3]
8 [A0AUZ9-4]

PTM databases

iPTMnetiA0AUZ9
PhosphoSitePlusiA0AUZ9

Expressioni

Gene expression databases

BgeeiENSG00000144445
CleanExiHS_C2orf67
ExpressionAtlasiA0AUZ9 baseline and differential
GenevisibleiA0AUZ9 HS

Organism-specific databases

HPAiHPA043102
HPA046790

Interactioni

Protein-protein interaction databases

IntActiA0AUZ9, 1 interactor
STRINGi9606.ENSP00000281772

Structurei

3D structure databases

ProteinModelPortaliA0AUZ9
SMRiA0AUZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVCE Eukaryota
ENOG4111T12 LUCA
GeneTreeiENSGT00530000063688
HOVERGENiHBG107580
InParanoidiA0AUZ9
OMAiCSTEWKW
OrthoDBiEOG091G08OO
PhylomeDBiA0AUZ9
TreeFamiTF336511

Family and domain databases

InterProiView protein in InterPro
IPR026180 NSL1
IPR029332 PEHE_dom
PANTHERiPTHR22443 PTHR22443, 1 hit
PfamiView protein in Pfam
PF15275 PEHE, 1 hit
SMARTiView protein in SMART
SM01300 PEHE, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0AUZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG
60 70 80 90 100
FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK
110 120 130 140 150
LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ
160 170 180 190 200
IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI
210 220 230 240 250
VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA
260 270 280 290 300
KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT
310 320 330 340 350
AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD
360 370 380 390 400
DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT
410 420 430 440 450
DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC
460 470 480 490 500
QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL
510 520 530 540 550
SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS
560 570 580 590 600
SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM
610 620 630 640 650
PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET
660 670 680 690 700
LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES
710 720 730 740 750
SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS
760 770 780 790 800
RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW
810 820 830 840 850
RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH
860 870 880 890 900
RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG
910 920 930 940 950
LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE
960 970 980
IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR
Length:987
Mass (Da):112,253
Last modified:February 26, 2008 - v2
Checksum:iFAAF236C850E6254
GO
Isoform 2 (identifier: A0AUZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-718: Missing.

Show »
Length:945
Mass (Da):107,452
Checksum:i601547FF92939BA6
GO
Isoform 3 (identifier: A0AUZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-705: VHSTLNQWRNGYSPICKPQIRSESSAQLL → GMSHLQFLYSICLFMSLYLLFLHSKKNKI
     706-987: Missing.

Show »
Length:705
Mass (Da):79,988
Checksum:iAFB81C92AEC5238E
GO
Isoform 4 (identifier: A0AUZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-648: DVPLHFHF → GKPPCNNF
     649-987: Missing.

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):73,235
Checksum:iEB01EB1EF725D095
GO

Sequence cautioni

The sequence BAB85085 differs from that shown. Reason: Frameshift at positions 496, 502, 550, 553, 673, 676, 755, 757 and 853.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB85085 differs from that shown. Reason: Erroneous termination at position 914. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401D → G in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti458D → G in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti471R → G in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti501S → F in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti587L → W in CAB61379 (PubMed:17974005).Curated1
Sequence conflicti606A → T in BAB71308 (PubMed:14702039).Curated1
Sequence conflicti756S → I in BAB85085 (PubMed:14702039).Curated1
Sequence conflicti848K → Q in BAB85085 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031497641 – 648DVPLHFHF → GKPPCNNF in isoform 4. 1 Publication8
Alternative sequenceiVSP_031498649 – 987Missing in isoform 4. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_031499677 – 718Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_031500677 – 705VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_031501706 – 987Missing in isoform 3. 2 PublicationsAdd BLAST282

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056911 mRNA Translation: BAB71308.1
AK074441 mRNA Translation: BAB85085.1 Sequence problems.
AC006994 Genomic DNA Translation: AAY14880.1
AC007038 Genomic DNA Translation: AAX93088.1
CH471063 Genomic DNA Translation: EAW70479.1
BC032837 mRNA Translation: AAH32837.1
BC070141 mRNA Translation: AAH70141.1
BC126155 mRNA Translation: AAI26156.1
BC143914 mRNA Translation: AAI43915.1
AL133053 mRNA Translation: CAB61379.1
CCDSiCCDS33370.1 [A0AUZ9-1]
CCDS77519.1 [A0AUZ9-2]
PIRiT42655
RefSeqiNP_001294905.1, NM_001307976.1 [A0AUZ9-2]
NP_689732.2, NM_152519.3 [A0AUZ9-1]
XP_005246386.1, XM_005246329.4 [A0AUZ9-1]
XP_005246387.1, XM_005246330.4 [A0AUZ9-1]
XP_011509008.1, XM_011510706.2 [A0AUZ9-1]
XP_011509009.1, XM_011510707.2 [A0AUZ9-1]
XP_016858919.1, XM_017003430.1 [A0AUZ9-1]
UniGeneiHs.282260
Hs.591638

Genome annotation databases

EnsembliENST00000281772; ENSP00000281772; ENSG00000144445 [A0AUZ9-1]
ENST00000418791; ENSP00000405724; ENSG00000144445 [A0AUZ9-2]
ENST00000452086; ENSP00000401408; ENSG00000144445 [A0AUZ9-3]
ENST00000457374; ENSP00000393432; ENSG00000144445 [A0AUZ9-3]
GeneIDi151050
KEGGihsa:151050
UCSCiuc002vds.4 human [A0AUZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKAL1L_HUMAN
AccessioniPrimary (citable) accession number: A0AUZ9
Secondary accession number(s): B7ZLN1
, I6L9A8, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 20, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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