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A0AUZ9

- KAL1L_HUMAN

UniProt

A0AUZ9 - KAL1L_HUMAN

Protein

KAT8 regulatory NSL complex subunit 1-like protein

Gene

KANSL1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KAT8 regulatory NSL complex subunit 1-like protein
    Alternative name(s):
    MSL1v2
    Gene namesi
    Name:KANSL1L
    Synonyms:C2orf67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26310. KANSL1L.

    Subcellular locationi

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162379439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 987987KAT8 regulatory NSL complex subunit 1-like proteinPRO_0000319582Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei859 – 8591N6-acetyllysine2 Publications

    Post-translational modificationi

    Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiA0AUZ9.
    PRIDEiA0AUZ9.

    PTM databases

    PhosphoSiteiA0AUZ9.

    Expressioni

    Gene expression databases

    ArrayExpressiA0AUZ9.
    BgeeiA0AUZ9.
    CleanExiHS_C2orf67.
    GenevestigatoriA0AUZ9.

    Organism-specific databases

    HPAiHPA043102.
    HPA046790.

    Interactioni

    Protein-protein interaction databases

    BioGridi127340. 1 interaction.
    IntActiA0AUZ9. 1 interaction.
    STRINGi9606.ENSP00000281772.

    Structurei

    3D structure databases

    ProteinModelPortaliA0AUZ9.
    SMRiA0AUZ9. Positions 796-841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG85593.
    HOVERGENiHBG107580.
    InParanoidiA0AUZ9.
    OMAiVNCSTEW.
    OrthoDBiEOG7VQJF6.
    PhylomeDBiA0AUZ9.
    TreeFamiTF336511.

    Family and domain databases

    InterProiIPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view]
    PANTHERiPTHR22443. PTHR22443. 1 hit.
    PfamiPF15275. PEHE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A0AUZ9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG    50
    FPTPEPTLNT NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK 100
    LGEPSCNKLK NILYNGSNIQ LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ 150
    IILDSNITKD TNVDKVQLQN CKWYQENALL DKVTDAEIKK GLLHCTQKKI 200
    VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR TQKHLQMLLA 250
    KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT 300
    AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD 350
    DLDEYTLRKN VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT 400
    DIHRQIRASK GIVVLEECQL PKDILKKQMQ FADQAASLNI LGNPQVPQEC 450
    QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL TEIINSLIAP LNLSPTSSPL 500
    SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK KRKDRTRLKS 550
    SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM 600
    PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET 650
    LLKKTEIKGN LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES 700
    SAQLLQGRKK RHLSETALGE RTKLEESDFQ HTESGSHSNF TAVSNVNVLS 750
    RIQNSSRNTA RRRLRSESSY DIDNIVIPMS LVAPAKLEKL QYKEILTPSW 800
    RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR WSLWEQSKWH 850
    RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG 900
    LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE 950
    IFGTSVPENG HHPKKQSDGM EEYKTFGLGL TNVKKNR 987
    Length:987
    Mass (Da):112,253
    Last modified:February 26, 2008 - v2
    Checksum:iFAAF236C850E6254
    GO
    Isoform 2 (identifier: A0AUZ9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         677-718: Missing.

    Show »
    Length:945
    Mass (Da):107,452
    Checksum:i601547FF92939BA6
    GO
    Isoform 3 (identifier: A0AUZ9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         677-705: VHSTLNQWRNGYSPICKPQIRSESSAQLL → GMSHLQFLYSICLFMSLYLLFLHSKKNKI
         706-987: Missing.

    Show »
    Length:705
    Mass (Da):79,988
    Checksum:iAFB81C92AEC5238E
    GO
    Isoform 4 (identifier: A0AUZ9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         641-648: DVPLHFHF → GKPPCNNF
         649-987: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:648
    Mass (Da):73,235
    Checksum:iEB01EB1EF725D095
    GO

    Sequence cautioni

    The sequence BAB85085.1 differs from that shown. Reason: Frameshift at positions 496, 502, 550, 553, 673, 676, 755, 757 and 853.
    The sequence BAB85085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB85085.1 differs from that shown. Reason: Erroneous termination at position 914. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti401 – 4011D → G in BAB71308. (PubMed:14702039)Curated
    Sequence conflicti458 – 4581D → G in BAB71308. (PubMed:14702039)Curated
    Sequence conflicti471 – 4711R → G in BAB85085. (PubMed:14702039)Curated
    Sequence conflicti501 – 5011S → F in BAB85085. (PubMed:14702039)Curated
    Sequence conflicti587 – 5871L → W in CAB61379. (PubMed:17974005)Curated
    Sequence conflicti606 – 6061A → T in BAB71308. (PubMed:14702039)Curated
    Sequence conflicti756 – 7561S → I in BAB85085. (PubMed:14702039)Curated
    Sequence conflicti848 – 8481K → Q in BAB85085. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei641 – 6488DVPLHFHF → GKPPCNNF in isoform 4. 1 PublicationVSP_031497
    Alternative sequencei649 – 987339Missing in isoform 4. 1 PublicationVSP_031498Add
    BLAST
    Alternative sequencei677 – 71842Missing in isoform 2. 1 PublicationVSP_031499Add
    BLAST
    Alternative sequencei677 – 70529VHSTL…SAQLL → GMSHLQFLYSICLFMSLYLL FLHSKKNKI in isoform 3. 2 PublicationsVSP_031500Add
    BLAST
    Alternative sequencei706 – 987282Missing in isoform 3. 2 PublicationsVSP_031501Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056911 mRNA. Translation: BAB71308.1.
    AK074441 mRNA. Translation: BAB85085.1. Sequence problems.
    AC006994 Genomic DNA. Translation: AAY14880.1.
    AC007038 Genomic DNA. Translation: AAX93088.1.
    CH471063 Genomic DNA. Translation: EAW70479.1.
    BC032837 mRNA. Translation: AAH32837.1.
    BC070141 mRNA. Translation: AAH70141.1.
    BC126155 mRNA. Translation: AAI26156.1.
    BC143914 mRNA. Translation: AAI43915.1.
    AL133053 mRNA. Translation: CAB61379.1.
    CCDSiCCDS33370.1. [A0AUZ9-1]
    PIRiT42655.
    RefSeqiNP_689732.2. NM_152519.2. [A0AUZ9-1]
    XP_005246386.1. XM_005246329.2. [A0AUZ9-1]
    XP_005246387.1. XM_005246330.2. [A0AUZ9-1]
    XP_005246390.1. XM_005246333.2. [A0AUZ9-2]
    XP_006712382.1. XM_006712319.1. [A0AUZ9-1]
    UniGeneiHs.282260.
    Hs.591638.

    Genome annotation databases

    EnsembliENST00000281772; ENSP00000281772; ENSG00000144445. [A0AUZ9-1]
    ENST00000418791; ENSP00000405724; ENSG00000144445. [A0AUZ9-2]
    ENST00000452086; ENSP00000401408; ENSG00000144445. [A0AUZ9-3]
    ENST00000457374; ENSP00000393432; ENSG00000144445. [A0AUZ9-3]
    GeneIDi151050.
    KEGGihsa:151050.
    UCSCiuc002vds.3. human. [A0AUZ9-1]
    uc002vdt.3. human. [A0AUZ9-2]
    uc002vdv.3. human.
    uc002vdx.1. human. [A0AUZ9-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056911 mRNA. Translation: BAB71308.1 .
    AK074441 mRNA. Translation: BAB85085.1 . Sequence problems.
    AC006994 Genomic DNA. Translation: AAY14880.1 .
    AC007038 Genomic DNA. Translation: AAX93088.1 .
    CH471063 Genomic DNA. Translation: EAW70479.1 .
    BC032837 mRNA. Translation: AAH32837.1 .
    BC070141 mRNA. Translation: AAH70141.1 .
    BC126155 mRNA. Translation: AAI26156.1 .
    BC143914 mRNA. Translation: AAI43915.1 .
    AL133053 mRNA. Translation: CAB61379.1 .
    CCDSi CCDS33370.1. [A0AUZ9-1 ]
    PIRi T42655.
    RefSeqi NP_689732.2. NM_152519.2. [A0AUZ9-1 ]
    XP_005246386.1. XM_005246329.2. [A0AUZ9-1 ]
    XP_005246387.1. XM_005246330.2. [A0AUZ9-1 ]
    XP_005246390.1. XM_005246333.2. [A0AUZ9-2 ]
    XP_006712382.1. XM_006712319.1. [A0AUZ9-1 ]
    UniGenei Hs.282260.
    Hs.591638.

    3D structure databases

    ProteinModelPortali A0AUZ9.
    SMRi A0AUZ9. Positions 796-841.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127340. 1 interaction.
    IntActi A0AUZ9. 1 interaction.
    STRINGi 9606.ENSP00000281772.

    PTM databases

    PhosphoSitei A0AUZ9.

    Proteomic databases

    PaxDbi A0AUZ9.
    PRIDEi A0AUZ9.

    Protocols and materials databases

    DNASUi 151050.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281772 ; ENSP00000281772 ; ENSG00000144445 . [A0AUZ9-1 ]
    ENST00000418791 ; ENSP00000405724 ; ENSG00000144445 . [A0AUZ9-2 ]
    ENST00000452086 ; ENSP00000401408 ; ENSG00000144445 . [A0AUZ9-3 ]
    ENST00000457374 ; ENSP00000393432 ; ENSG00000144445 . [A0AUZ9-3 ]
    GeneIDi 151050.
    KEGGi hsa:151050.
    UCSCi uc002vds.3. human. [A0AUZ9-1 ]
    uc002vdt.3. human. [A0AUZ9-2 ]
    uc002vdv.3. human.
    uc002vdx.1. human. [A0AUZ9-4 ]

    Organism-specific databases

    CTDi 151050.
    GeneCardsi GC02M210886.
    H-InvDB HIX0161858.
    HGNCi HGNC:26310. KANSL1L.
    HPAi HPA043102.
    HPA046790.
    MIMi 613833. gene.
    neXtProti NX_A0AUZ9.
    PharmGKBi PA162379439.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85593.
    HOVERGENi HBG107580.
    InParanoidi A0AUZ9.
    OMAi VNCSTEW.
    OrthoDBi EOG7VQJF6.
    PhylomeDBi A0AUZ9.
    TreeFami TF336511.

    Miscellaneous databases

    GenomeRNAii 151050.
    NextBioi 35533880.
    PROi A0AUZ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A0AUZ9.
    Bgeei A0AUZ9.
    CleanExi HS_C2orf67.
    Genevestigatori A0AUZ9.

    Family and domain databases

    InterProi IPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view ]
    PANTHERi PTHR22443. PTHR22443. 1 hit.
    Pfami PF15275. PEHE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Lung and Prostate.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-987 (ISOFORM 4).
      Tissue: Brain and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 532-987 (ISOFORM 1).
      Tissue: Testis.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-859, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "DNA damage induced MutS homologue hMSH4 acetylation."
      Chu Y.L., Wu X., Xu J., Watts J.L., Her C.
      Int. J. Mol. Sci. 14:20966-20982(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION BY KAT8, DEACETYLATION BY HDAC3.

    Entry informationi

    Entry nameiKAL1L_HUMAN
    AccessioniPrimary (citable) accession number: A0AUZ9
    Secondary accession number(s): B7ZLN1
    , I6L9A8, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3