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Protein

Proteasome subunit beta type

Gene

Prosbeta1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: FlyBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Prosbeta1Imported
Synonyms:l(2)05070Imported, l(2)05070-RAImported
ORF Names:CG8392Imported, Dmel_CG8392Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010590. Prosbeta1.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • proteasome complex Source: FlyBase
  • proteasome core complex Source: FlyBase
  • proteasome core complex, beta-subunit complex Source: FlyBase

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

Expressioni

Gene expression databases

BgeeiFBgn0010590.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

Protein-protein interaction databases

IntActiA0AQH0. 1 interactor.
STRINGi7227.FBpp0086400.

Structurei

3D structure databases

SMRiA0AQH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0174. Eukaryota.
ENOG410XS23. LUCA.
GeneTreeiENSGT00510000046484.
KOiK02738.
OMAiHDRIYCC.
OrthoDBiEOG091G0GUI.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0AQH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPDFDFTDT PVSTGTTIMA VEFDGGVVIG ADSRTSSGAY VANRVTDKLT
60 70 80 90 100
RITDKVYCCR SGSAADTQAI ADIVAYSLNY HENQTNKDAL VFEAASEFRN
110 120 130 140 150
YCYSYRESLL AGIIVAGWDE QRGGQVYSIP LGGMLTRESC TIGGSGSSFI
160 170 180 190 200
YGFVREHYRP NMALEDCVTF VKKAVQHAIY HDGSSGGVVR IGIITKDGIE
210 220
RRIFYNTESG ASAVSSTPSF ISSE
Length:224
Mass (Da):24,264
Last modified:November 28, 2006 - v1
Checksum:iD52648A5240701BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58077.1.
BT044319 mRNA. Translation: ACH92384.1.
AM294908 Genomic DNA. Translation: CAL26894.1.
AM294909 Genomic DNA. Translation: CAL26895.1.
AM294910 Genomic DNA. Translation: CAL26896.1.
AM294911 Genomic DNA. Translation: CAL26897.1.
AM294912 Genomic DNA. Translation: CAL26898.1.
AM294913 Genomic DNA. Translation: CAL26899.1.
AM294914 Genomic DNA. Translation: CAL26900.1.
AM294915 Genomic DNA. Translation: CAL26901.1.
AM294916 Genomic DNA. Translation: CAL26902.1.
AM294917 Genomic DNA. Translation: CAL26903.1.
AM294918 Genomic DNA. Translation: CAL26904.1.
FM245703 Genomic DNA. Translation: CAR93629.1.
FM245704 Genomic DNA. Translation: CAR93630.1.
FM245705 Genomic DNA. Translation: CAR93631.1.
FM245706 Genomic DNA. Translation: CAR93632.1.
FM245707 Genomic DNA. Translation: CAR93633.1.
FM245708 Genomic DNA. Translation: CAR93634.1.
FM245709 Genomic DNA. Translation: CAR93635.1.
FM245710 Genomic DNA. Translation: CAR93636.1.
FM245711 Genomic DNA. Translation: CAR93637.1.
FM245712 Genomic DNA. Translation: CAR93638.1.
FM245713 Genomic DNA. Translation: CAR93639.1.
FM245714 Genomic DNA. Translation: CAR93640.1.
RefSeqiNP_652031.2. NM_143774.3.
UniGeneiDm.20314.

Genome annotation databases

EnsemblMetazoaiFBtr0087262; FBpp0086400; FBgn0010590.
GeneIDi46058.
KEGGidme:Dmel_CG8392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58077.1.
BT044319 mRNA. Translation: ACH92384.1.
AM294908 Genomic DNA. Translation: CAL26894.1.
AM294909 Genomic DNA. Translation: CAL26895.1.
AM294910 Genomic DNA. Translation: CAL26896.1.
AM294911 Genomic DNA. Translation: CAL26897.1.
AM294912 Genomic DNA. Translation: CAL26898.1.
AM294913 Genomic DNA. Translation: CAL26899.1.
AM294914 Genomic DNA. Translation: CAL26900.1.
AM294915 Genomic DNA. Translation: CAL26901.1.
AM294916 Genomic DNA. Translation: CAL26902.1.
AM294917 Genomic DNA. Translation: CAL26903.1.
AM294918 Genomic DNA. Translation: CAL26904.1.
FM245703 Genomic DNA. Translation: CAR93629.1.
FM245704 Genomic DNA. Translation: CAR93630.1.
FM245705 Genomic DNA. Translation: CAR93631.1.
FM245706 Genomic DNA. Translation: CAR93632.1.
FM245707 Genomic DNA. Translation: CAR93633.1.
FM245708 Genomic DNA. Translation: CAR93634.1.
FM245709 Genomic DNA. Translation: CAR93635.1.
FM245710 Genomic DNA. Translation: CAR93636.1.
FM245711 Genomic DNA. Translation: CAR93637.1.
FM245712 Genomic DNA. Translation: CAR93638.1.
FM245713 Genomic DNA. Translation: CAR93639.1.
FM245714 Genomic DNA. Translation: CAR93640.1.
RefSeqiNP_652031.2. NM_143774.3.
UniGeneiDm.20314.

3D structure databases

SMRiA0AQH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0AQH0. 1 interactor.
STRINGi7227.FBpp0086400.

Protein family/group databases

MEROPSiT01.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087262; FBpp0086400; FBgn0010590.
GeneIDi46058.
KEGGidme:Dmel_CG8392.

Organism-specific databases

CTDi46058.
FlyBaseiFBgn0010590. Prosbeta1.

Phylogenomic databases

eggNOGiKOG0174. Eukaryota.
ENOG410XS23. LUCA.
GeneTreeiENSGT00510000046484.
KOiK02738.
OMAiHDRIYCC.
OrthoDBiEOG091G0GUI.

Enzyme and pathway databases

ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii46058.

Gene expression databases

BgeeiFBgn0010590.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0AQH0_DROME
AccessioniPrimary (citable) accession number: A0AQH0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.