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Protein

Nucleoid occlusion protein

Gene

noc

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi143 – 162H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion proteinUniRule annotation
Short name:
NocUniRule annotation
Gene namesi
Name:nocUniRule annotation
Ordered Locus Names:lwe2737
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

Subcellular locationi

  • Cytoplasmnucleoid UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003466341 – 284Nucleoid occlusion proteinAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi386043.lwe2737.

Structurei

3D structure databases

ProteinModelPortaliA0AMC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ParB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410636K. Bacteria.
COG1475. LUCA.
HOGENOMiHOG000088074.
KOiK03497.
OMAiSQSYVAN.
OrthoDBiPOG091H0253.

Family and domain databases

HAMAPiMF_02015. ParB_Noc. 1 hit.
InterProiIPR023705. Nucleoid_occlusion_protein.
IPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
[Graphical view]
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
TIGRFAMsiTIGR04285. nucleoid_noc. 1 hit.
TIGR00180. parB_part. 1 hit.

Sequencei

Sequence statusi: Complete.

A0AMC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSRLFGKK EKNQMDDIVE EGVQRVLELP MDKIFPNQFQ PRTVFDQDKI
60 70 80 90 100
DELARTIRIH GVIQPIVVRE MEPDYYEIIA GERRFRAVLS LELEKIPAII
110 120 130 140 150
QNLDDEEVAA IALIENLQRE ELTPIEEAKA YRSLLDMQDV TQEALAQRVG
160 170 180 190 200
KSQSAIANKL RLLKLPEAVQ QAVLNKQISE RHARSLLALE TEATQVDLLA
210 220 230 240 250
EIEENHWNVK QTEARIQEIL GVKKPTTTKK TKPKRQAISR DVRIAMNTIK
260 270 280
QSVTMVKDNG MDLDFKEEET DDFYQITIQI PKKK
Length:284
Mass (Da):32,770
Last modified:November 28, 2006 - v1
Checksum:iC2776F3D4D573EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK22155.1.
RefSeqiWP_011703426.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK22155; CAK22155; lwe2737.
KEGGilwe:lwe2737.
PATRICi20332741. VBILisWel39304_2744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK22155.1.
RefSeqiWP_011703426.1. NC_008555.1.

3D structure databases

ProteinModelPortaliA0AMC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386043.lwe2737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK22155; CAK22155; lwe2737.
KEGGilwe:lwe2737.
PATRICi20332741. VBILisWel39304_2744.

Phylogenomic databases

eggNOGiENOG410636K. Bacteria.
COG1475. LUCA.
HOGENOMiHOG000088074.
KOiK03497.
OMAiSQSYVAN.
OrthoDBiPOG091H0253.

Family and domain databases

HAMAPiMF_02015. ParB_Noc. 1 hit.
InterProiIPR023705. Nucleoid_occlusion_protein.
IPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
[Graphical view]
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
TIGRFAMsiTIGR04285. nucleoid_noc. 1 hit.
TIGR00180. parB_part. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC_LISW6
AccessioniPrimary (citable) accession number: A0AMC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.