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Protein

Pyrophosphatase PpaX

Gene

ppaX

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-2505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrophosphatase PpaXUniRule annotation (EC:3.6.1.1UniRule annotation)
Gene namesi
Name:ppaXUniRule annotation
Ordered Locus Names:lwe2429
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Pyrophosphatase PpaXPRO_1000067190Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386043.lwe2429.

Structurei

3D structure databases

ProteinModelPortaliA0ALG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PpaX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107XGZ. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK06019.
OMAiHAEEMRV.
OrthoDBiEOG6K404V.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01250. Pyrophosphat_PpaX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR023733. Pyrophosphatase_Ppax.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0ALG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKITTLLF DLDGTLINTN ELIIKTFQAT LQEFLPDRVF TREDILPFIG
60 70 80 90 100
PSLMETFREI NPAHAEEMRV FYREYNLKHH DDLILEYEGV YEAIRVLYEE
110 120 130 140 150
DYKLGIVSTK MYDTIMRGLK VTGLDKFFQV VIGLDQVSNA KPDPEGIEMA
160 170 180 190 200
LSLLNATKEE AIMIGDNYHD IEAGKNAETL TAGVAWAIKG PEHLAQFQPD
210
FMLEKMSDLL AIVRDEE
Length:217
Mass (Da):24,768
Last modified:November 28, 2006 - v1
Checksum:iA1CF491B86420A2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21847.1.
RefSeqiWP_011703165.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK21847; CAK21847; lwe2429.
KEGGilwe:lwe2429.
PATRICi20332115. VBILisWel39304_2438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21847.1.
RefSeqiWP_011703165.1. NC_008555.1.

3D structure databases

ProteinModelPortaliA0ALG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386043.lwe2429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK21847; CAK21847; lwe2429.
KEGGilwe:lwe2429.
PATRICi20332115. VBILisWel39304_2438.

Phylogenomic databases

eggNOGiENOG4107XGZ. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK06019.
OMAiHAEEMRV.
OrthoDBiEOG6K404V.

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-2505-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01250. Pyrophosphat_PpaX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR023733. Pyrophosphatase_Ppax.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
    Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.
    , Lampidis R., Kreft J., Goebel W., Chakraborty T.
    J. Bacteriol. 188:7405-7415(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35897 / DSM 20650 / SLCC5334.

Entry informationi

Entry nameiPPAX_LISW6
AccessioniPrimary (citable) accession number: A0ALG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 28, 2006
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.