ID   NAMA_LISW6              Reviewed;         338 AA.
AC   A0ALF5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=NADPH dehydrogenase;
DE            EC=1.6.99.1;
DE   AltName: Full=Xenobiotic reductase;
GN   Name=namA; OrderedLocusNames=lwe2419;
OS   Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 /
OS   SLCC5334).
OC   Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=386043;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16936040; DOI=10.1128/JB.00758-06;
RA   Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R.,
RA   Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T.,
RA   Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J.,
RA   Liang C., Dandekar T., Lampidis R., Kreft J., Goebel W.,
RA   Chakraborty T.;
RT   "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT   genome reduction with Listeria innocua as compared to Listeria
RT   monocytogenes.";
RL   J. Bacteriol. 188:7405-7415(2006).
CC   -!- FUNCTION: Catalyzes the reduction of the double bond of an array
CC       of alpha, beta-unsaturated aldehydes and ketones. It also reduces
CC       the nitro group of nitroester and nitroaromatic compounds. It
CC       could have a role in detoxification processes (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + acceptor = NADP(+) + reduced acceptor.
CC   -!- COFACTOR: FMN (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. NamA subfamily.
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DR   EMBL; AM263198; CAK21837.1; -; Genomic_DNA.
DR   RefSeq; YP_850616.1; -.
DR   GeneID; 4464713; -.
DR   GenomeReviews; AM263198_GR; lwe2419.
DR   KEGG; lwe:lwe2419; -.
DR   NMPDR; fig|386043.6.peg.2350; -.
DR   OMA; A0ALF5; WVEDGWN.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0003959; F:NADPH dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01614; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00724; Oxidored_FMN; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN         1    338       NADPH dehydrogenase.
FT                                /FTId=PRO_1000069458.
FT   NP_BIND      22     26       FMN (By similarity).
FT   BINDING      27     27       Substrate (By similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     166    166       Substrate (By similarity).
FT   BINDING     214    214       FMN (By similarity).
FT   BINDING     307    307       FMN (By similarity).
SQ   SEQUENCE   338 AA;  36966 MW;  983EB10CB1DE0572 CRC64;
     MSKLFSEYKL KDVTLKNRIV MSPMCMYSVE NKDGIATDFH FAHYVSRAAG GTGLVILEAT
     AVQEVGRISE FDLGLWNDEQ VPALKHLVDG LHSHGAKAGI QLAHAGRKAV LPGEIVAPSA
     IAYDEKSAKP VELTKEAIKE VVADFKRAAY RAKEAGFDVI EIHAAHGYLI HQFLSPITNR
     REDNYGGPAG NRYKILSDII KAVKEVWDGP IIVRVSATDY AHGGLQLEDY IPFAKWMKAD
     GVELIDVSTG GLVNVAPPVF PGYQVPFADE IRRGAGIATG VLGLITRGEQ AEEILCNERA
     DLIIIGRELL RNPYFAKDAA LSLGETIEGP KQYSRAWK
//