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Reviewed, UniProtKB/Swiss-Prot A0ALF5 (NAMA_LISW6)

Last modified June 16, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NADPH dehydrogenase
    EC=1.6.99.1
Alternative name(s):
    Xenobiotic reductase
Gene names
Name: namA
Ordered Locus Names: lwe2419
OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) [Complete proteome] [HAMAP]
Taxonomic identifier386043 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

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Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity.

Catalytic activity

NADPH + acceptor = NADP+ + reduced acceptor. HAMAP MF_01614

Cofactor

FMN By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

NADPH dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338NADPH dehydrogenase HAMAP MF_01614
PRO_1000069458

Regions

Nucleotide binding22 – 265FMN By similarity

Sites

Binding site271Substrate By similarity
Binding site1631Substrate By similarity
Binding site1661Substrate By similarity
Binding site2141FMN By similarity
Binding site3071FMN By similarity

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Sequences

Sequence LengthMass (Da)Tools
A0ALF5-1 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: 983EB10CB1DE0572

FASTA33836,966
        10         20         30         40         50         60 
MSKLFSEYKL KDVTLKNRIV MSPMCMYSVE NKDGIATDFH FAHYVSRAAG GTGLVILEAT 

        70         80         90        100        110        120 
AVQEVGRISE FDLGLWNDEQ VPALKHLVDG LHSHGAKAGI QLAHAGRKAV LPGEIVAPSA 

       130        140        150        160        170        180 
IAYDEKSAKP VELTKEAIKE VVADFKRAAY RAKEAGFDVI EIHAAHGYLI HQFLSPITNR 

       190        200        210        220        230        240 
REDNYGGPAG NRYKILSDII KAVKEVWDGP IIVRVSATDY AHGGLQLEDY IPFAKWMKAD 

       250        260        270        280        290        300 
GVELIDVSTG GLVNVAPPVF PGYQVPFADE IRRGAGIATG VLGLITRGEQ AEEILCNERA 

       310        320        330 
DLIIIGRELL RNPYFAKDAA LSLGETIEGP KQYSRAWK

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References

[1]"Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T. expand/collapse author list , Lampidis R., Kreft J., Goebel W., Chakraborty T.
J. Bacteriol. 188:7405-7415(2006) [PubMed: 16936040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AM263198 Genomic DNA. Translation: CAK21837.1.
RefSeqYP_850616.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4464713.
GenomeReviewsGene locus lwe2419 in contig AM263198_GR.
KEGGlwe:lwe2419.
NMPDRfig|386043.6.peg.2350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAA0ALF5. WVEDGWN.

Family and domain databases

HAMAPMF_01614.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNAMA_LISW6
AccessionPrimary (citable) accession number: A0ALF5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 28, 2006
Last modified: June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents