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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Manganese 2UniRule annotation
Active sitei62 – 621Phosphoserine intermediateUniRule annotation
Metal bindingi62 – 621Manganese 2UniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei185 – 1851SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei335 – 3351SubstrateUniRule annotation
Metal bindingi402 – 4021Manganese 1UniRule annotation
Metal bindingi406 – 4061Manganese 1UniRule annotation
Metal bindingi443 – 4431Manganese 2UniRule annotation
Metal bindingi444 – 4441Manganese 2UniRule annotation
Metal bindingi461 – 4611Manganese 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-2479-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Ordered Locus Names:lwe2404
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5105102,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_1000063980Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi386043.lwe2404.

Structurei

3D structure databases

ProteinModelPortaliA0ALE0.
SMRiA0ALE0. Positions 2-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 1542Substrate bindingUniRule annotation
Regioni260 – 2634Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.
OrthoDBiPOG091H01EL.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

A0ALE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSPVAIII LDGFGKRAET VGNAVAQANK PNFDRYWADF PHGELKAAGL
60 70 80 90 100
DVGLPEGQMG NSEVGHTNIG AGRIVYQSLT RIDKAIEEGE FQENKALNNA
110 120 130 140 150
FTHTKENNSD LHLFGLLSDG GVHSHINHLV ALLETAKDKG VKNVYIHAFL
160 170 180 190 200
DGRDVAPQSS LEYLETLQKA MNDLNYGEIA TVSGRFYAMD RDKRWERVEK
210 220 230 240 250
AYKAIVSAEG EKFEDPIELV KASYANDKND EFVVPAIITK DGKPVATVKD
260 270 280 290 300
NDAVIFFNFR PDRAIQLSNA FTDKEWDHFD RGANHPKNIK FVTMTLYNPS
310 320 330 340 350
VDAEVAFEPI EMKNVIGEVL SNEGLSQLRI AETEKYPHVT FFMNGGRNEE
360 370 380 390 400
FPGENRILIN SPKVETYDLQ PEMSAYEVTD ALVEDIKNDK HDAIILNFAN
410 420 430 440 450
PDMVGHSGML EPTIKAIEAV DENLGRVVDL ILEKGGSAII FADHGNSETM
460 470 480 490 500
STPEGKPHTA HTTVPVPVIV TKKGVKLREG GRLADVAPTM LDLLGVKKPA
510
EMTGESLIQK
Length:510
Mass (Da):56,255
Last modified:November 28, 2006 - v1
Checksum:i482727956D25E30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21822.1.
RefSeqiWP_011703142.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK21822; CAK21822; lwe2404.
KEGGilwe:lwe2404.
PATRICi20332065. VBILisWel39304_2414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21822.1.
RefSeqiWP_011703142.1. NC_008555.1.

3D structure databases

ProteinModelPortaliA0ALE0.
SMRiA0ALE0. Positions 2-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386043.lwe2404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK21822; CAK21822; lwe2404.
KEGGilwe:lwe2404.
PATRICi20332065. VBILisWel39304_2414.

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.
OrthoDBiPOG091H01EL.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciLWEL386043:GI5X-2479-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPMI_LISW6
AccessioniPrimary (citable) accession number: A0ALE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.