Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0AKW4 (A0AKW4_LISW6) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323 EMBL CAK21646.1
Ordered Locus Names:lwe2228
OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) [Complete proteome] [HAMAP] EMBL CAK21646.1
Taxonomic identifier386043 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1821Iron By similarity HAMAP MF_00323
Metal binding2631Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A0AKW4 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: D96DBA35ED0C5EDF

FASTA30935,274
        10         20         30         40         50         60 
MAKKVGLLVM AYGTPYKDED IERYYTDIRH GHTPSEEMIA DLRGRYHAIG GLSPLAKITE 

        70         80         90        100        110        120 
AQAYGLEEVL NKSQEEVEFK TYIGLKHIEP FIEDAVEAMH KDGIKEAISI VLAPHYSSFS 

       130        140        150        160        170        180 
VEAYNKRAKD TADKLGGIEI KAINEWYKQP KFINMWAERI NETAKQIPAD ELMDTVLIVS 

       190        200        210        220        230        240 
AHSLPEKIKQ HNDPYPDQLQ ETADLIFEKV VVPHYALGWQ SEGKTGEPWL GPDVQDLTRA 

       250        260        270        280        290        300 
LYGKEKYKHF IYTPVGFVAE HLEVLYDNDY ECKVVTDEVG AAYHRPPMPN ADPEFLEVLK 


TVVWEKYTN

« Hide

References

[1]"Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T. expand/collapse author list , Lampidis R., Kreft J., Goebel W., Chakraborty T.
J. Bacteriol. 188:7405-7415(2006) [PubMed: 16936040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM263198 Genomic DNA. Translation: CAK21646.1.
RefSeqYP_850425.1. NC_008555.1.

3D structure databases

ProteinModelPortalA0AKW4.
SMRA0AKW4. Positions 3-306.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0AKW4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4465237.
GenomeReviewsGene locus lwe2228 in contig AM263198_GR.
KEGGlwe:lwe2228.
NMPDRfig|386043.6.peg.2167.
PATRIC20331677. VBILisWel39304_2239.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMASWYDEPK.
PhylomeDBA0AKW4.
ProtClustDBPRK12435.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0AKW4_LISW6
AccessionPrimary (citable) accession number: A0AKW4
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info