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A0AKJ7

- ASSY_LISW6

UniProt

A0AKJ7 - ASSY_LISW6

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Protein
Argininosuccinate synthase
Gene
argG, lwe2111
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei174 – 1741Citrulline By similarity
Binding sitei183 – 1831Citrulline By similarity
Binding sitei259 – 2591Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-2162-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:lwe2111
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000779: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Argininosuccinate synthaseUniRule annotation
PRO_1000000404Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386043.lwe2111.

Structurei

3D structure databases

ProteinModelPortaliA0AKJ7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0AKJ7-1 [UniParc]FASTAAdd to Basket

« Hide

MTKEKIVLAY SGGLDTSVAI QWLVESGYEV IACCLDVGEG KNLDFIKEKA    50
ITVGASESYT IDAKEEFAED FALIALQAHA YYEGKYPLIS ALSRPLIAKK 100
LVEVARQEGA SAIAHGCTGK GNDQVRFEVA IHALAPDLKV ISPVRDWKWS 150
REEEINYAKE HNIPVPIDLD NPFSIDQNLW GRSNECGVLE NPWTTPPEAA 200
YDLTVSLEDA PDTADIVEIT FDAGIPISLN GENMSLANLI LTLNEIAGKH 250
GVGRIDHIEN RLVGIKSREV YECPAAVTLI KAHKELEDLT FVREVAHFKP 300
IIEQKISETI YNGLWFSPLT EALVAFLKST QKFVNGTIRV KLFKGHAIVE 350
GRKSPNSLYD ENLATYTSSD TFDQDAAVGF IKLWGLPTKV SAEVNSKVTI 400
TTEV 404
Length:404
Mass (Da):44,523
Last modified:November 28, 2006 - v1
Checksum:i174F442EBEB29F1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM263198 Genomic DNA. Translation: CAK21529.1.
RefSeqiYP_850308.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK21529; CAK21529; lwe2111.
GeneIDi4464966.
KEGGilwe:lwe2111.
PATRICi20331431. VBILisWel39304_2121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM263198 Genomic DNA. Translation: CAK21529.1 .
RefSeqi YP_850308.1. NC_008555.1.

3D structure databases

ProteinModelPortali A0AKJ7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 386043.lwe2111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK21529 ; CAK21529 ; lwe2111 .
GeneIDi 4464966.
KEGGi lwe:lwe2111.
PATRICi 20331431. VBILisWel39304_2121.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LWEL386043:GI5X-2162-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
    Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.
    , Lampidis R., Kreft J., Goebel W., Chakraborty T.
    J. Bacteriol. 188:7405-7415(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35897 / DSM 20650 / SLCC5334.

Entry informationi

Entry nameiASSY_LISW6
AccessioniPrimary (citable) accession number: A0AKJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 28, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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