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A0AK45

- GCH1_LISW6

UniProt

A0AK45 - GCH1_LISW6

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781ZincUniRule annotation
    Metal bindingi81 – 811ZincUniRule annotation
    Metal bindingi150 – 1501ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciLWEL386043:GI5X-2009-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:lwe1959
    OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
    Taxonomic identifieri386043 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000779: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189GTP cyclohydrolase 1PRO_1000043705Add
    BLAST

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Protein-protein interaction databases

    STRINGi386043.lwe1959.

    Structurei

    3D structure databases

    ProteinModelPortaliA0AK45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiKRTYDEE.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0AK45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQIDKQKIA DAVKVILEAV GENPEREGLI DTPMRVARMY EEVFSGLKKD    50
    PSIHFDTIFA EQHEELVLVK DIRFSSMCEH HLVPFFGVAH VAYLPQNGRV 100
    AGLSKLARVV DDVSKRPQLQ ERITTTVAEI MMDKLKPLGV MVIMEAEHMC 150
    MTIRGVNKPG TKTITSAVRG AFKNDDKLRS EVLALIKHN 189
    Length:189
    Mass (Da):21,265
    Last modified:November 28, 2006 - v1
    Checksum:i8373E0D76A553F08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM263198 Genomic DNA. Translation: CAK21377.1.
    RefSeqiWP_011702725.1. NC_008555.1.
    YP_850156.1. NC_008555.1.

    Genome annotation databases

    EnsemblBacteriaiCAK21377; CAK21377; lwe1959.
    GeneIDi4465157.
    KEGGilwe:lwe1959.
    PATRICi20331125. VBILisWel39304_1969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM263198 Genomic DNA. Translation: CAK21377.1 .
    RefSeqi WP_011702725.1. NC_008555.1.
    YP_850156.1. NC_008555.1.

    3D structure databases

    ProteinModelPortali A0AK45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386043.lwe1959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK21377 ; CAK21377 ; lwe1959 .
    GeneIDi 4465157.
    KEGGi lwe:lwe1959.
    PATRICi 20331125. VBILisWel39304_1969.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi KRTYDEE.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci LWEL386043:GI5X-2009-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
      Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.
      , Lampidis R., Kreft J., Goebel W., Chakraborty T.
      J. Bacteriol. 188:7405-7415(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35897 / DSM 20650 / SLCC5334.

    Entry informationi

    Entry nameiGCH1_LISW6
    AccessioniPrimary (citable) accession number: A0AK45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3