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Protein

Bifunctional ligase/repressor BirA

Gene

birA

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.UniRule annotation

Catalytic activityi

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161BiotinUniRule annotation
Binding sitei187 – 1871BiotinUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi22 – 4120H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, BiotinUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-1973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ligase/repressor BirAUniRule annotation
Alternative name(s):
Biotin--[acetyl-CoA-carboxylase] ligaseUniRule annotation
Biotin--protein ligaseUniRule annotation
Biotin-[acetyl-CoA carboxylase] synthetaseUniRule annotation
Gene namesi
Name:birAUniRule annotationImported
Ordered Locus Names:lwe1923Imported
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)Imported
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi386043.lwe1923.

Structurei

3D structure databases

ProteinModelPortaliA0AK09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 258192BPL/LPL catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the biotin--protein ligase family.UniRule annotation
Contains 1 BPL/LPL catalytic domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HJX. Bacteria.
COG0340. LUCA.
COG1654. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiFTESDGA.
OrthoDBiPOG091H01NJ.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00978. Bifunct_BirA. 1 hit.
InterProiIPR030855. Bifunct_BirA.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR013196. HTH_11.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0AK09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNNREKLLA LFTESDGAYL SGQEIADSLG CSRTAVWKQM EALRKEGFEI
60 70 80 90 100
EAVRNRGYRL SATAEQYTKD ALLLGLETKF IGQHIEIHES VSSTQIIAHQ
110 120 130 140 150
QIDTSPEGTV IVADEQTAGK GRLLRPWNSK KGEGIWMSVI LKPQIPIQKV
160 170 180 190 200
PQFTFIASLA ITEAIENITK LEPRIKWPND IYIGKRKICG VLTEMQAEAE
210 220 230 240 250
TIHAVIIGMG INVNQQVFPE EIKDKASSLK LELGESISRK ALLQEILASL
260 270 280 290 300
EKYYELFLDK GFAPIKLLWE TKAIPFGEKL TASTTKGKIY GKVQGISDEG
310 320
VLLLQDNLGE VHSIYSADIL LDNEK
Length:325
Mass (Da):36,228
Last modified:November 28, 2006 - v1
Checksum:i27C742481368140D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21341.1.
RefSeqiWP_011702689.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK21341; CAK21341; lwe1923.
KEGGilwe:lwe1923.
PATRICi20331053. VBILisWel39304_1933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA. Translation: CAK21341.1.
RefSeqiWP_011702689.1. NC_008555.1.

3D structure databases

ProteinModelPortaliA0AK09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386043.lwe1923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK21341; CAK21341; lwe1923.
KEGGilwe:lwe1923.
PATRICi20331053. VBILisWel39304_1933.

Phylogenomic databases

eggNOGiENOG4105HJX. Bacteria.
COG0340. LUCA.
COG1654. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiFTESDGA.
OrthoDBiPOG091H01NJ.

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-1973-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00978. Bifunct_BirA. 1 hit.
InterProiIPR030855. Bifunct_BirA.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR013196. HTH_11.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0AK09_LISW6
AccessioniPrimary (citable) accession number: A0AK09
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.