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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLWEL386043:G1GJF-1954-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:lwe1896
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005281 – 560Formate--tetrahydrofolate ligaseAdd BLAST560

Proteomic databases

PRIDEiA0AJY2

Interactioni

Protein-protein interaction databases

STRINGi386043.lwe1896

Structurei

3D structure databases

ProteinModelPortaliA0AJY2
SMRiA0AJY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0AJY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKVKSDIE IASKAEILPV TTIAKHLGLD ADALELYGKY KAKLSYDTIH
60 70 80 90 100
SLKDQEPGKL VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP
110 120 130 140 150
SLGPTMGIKG GATGGGYAQV IPMEDINLHF TGDFHAITAA NNALSAFIDN
160 170 180 190 200
HMQQGNELGI DGRRIVWKRV VDLNDRALRK VVVGLGGPVQ GVPREDGFDI
210 220 230 240 250
TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG EMGYEGALTL
260 270 280 290 300
LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALRLGDYVV
310 320 330 340 350
TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS
360 370 380 390 400
EENVEALAKG FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEALC
410 420 430 440 450
EEHGIPFSLT EVWEKGGDGG LELADKVIAA VESGEADYNR IYDDAWSMEE
460 470 480 490 500
KLEAIVTKVY GGIGVELSSK AQKQIVEFKK YGWDRYPICM AKTQYSLSDD
510 520 530 540 550
PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP KKPAALNMDV
560
DENGNAQGLF
Length:560
Mass (Da):60,071
Last modified:November 28, 2006 - v1
Checksum:iD37929796A267049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA Translation: CAK21314.1
RefSeqiWP_011702663.1, NC_008555.1

Genome annotation databases

EnsemblBacteriaiCAK21314; CAK21314; lwe1896
KEGGilwe:lwe1896

Similar proteinsi

Entry informationi

Entry nameiFTHS_LISW6
AccessioniPrimary (citable) accession number: A0AJY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health