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A0AJT6 (A0AJT6_LISW6) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL CAK21268.1
Ordered Locus Names:lwe1850
OrganismListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) [Complete proteome] [HAMAP] EMBL CAK21268.1
Taxonomic identifier386043 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region122 – 13095-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1261Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A0AJT6 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: 6D43FDCBA26C539C

FASTA20922,794
        10         20         30         40         50         60 
MSIEKQVAEQ LLEIKAVFLK PNDPFTWASG IKSPIYCDNR LTLGFPKVRQ FIAESLAEKI 

        70         80         90        100        110        120 
KETFGEVDVV AGTATAGIPH AAWVSDLLDL PMVYVRSKAK EHGKGNQIEG LIAKGQKVVV 

       130        140        150        160        170        180 
IEDLISTGGS SLKAVEALEE AGAEVLGIAA IFTYGLDKGK KLLAESNTKL ITLTNYDELI 

       190        200 
EVALNKDYVT AEDMATLKEW KKSPENWGK

« Hide

References

[1]"Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T. expand/collapse author list , Lampidis R., Kreft J., Goebel W., Chakraborty T.
J. Bacteriol. 188:7405-7415(2006) [PubMed: 16936040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM263198 Genomic DNA. Translation: CAK21268.1.
RefSeqYP_850047.1. NC_008555.1.

3D structure databases

ProteinModelPortalA0AJT6.
SMRA0AJT6. Positions 1-208.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0AJT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4465482.
GenomeReviewsGene locus lwe1850 in contig AM263198_GR.
KEGGlwe:lwe1850.
NMPDRfig|386043.6.peg.1798.
PATRIC20330905. VBILisWel39304_1859.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMALPMTYVR.
PhylomeDBA0AJT6.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0AJT6_LISW6
AccessionPrimary (citable) accession number: A0AJT6
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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