A0AJS6 (STP1_LISW6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine phosphatase stp
EC=3.1.3.16

Gene names

Name:	stp
Ordered Locus Names:	lwe1840

Organism

Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) [Complete proteome] [HAMAP]

Taxonomic identifier

386043 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria welshimeri

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Protein phosphatase that dephosphorylates EF-Tu By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Serine/threonine phosphatase stp		PRO_0000363065
Regions
	Domain	2 – 235	234	PP2C-like
Sites
	Metal binding	36	1	Manganese 1 By similarity
	Metal binding	36	1	Manganese 2 By similarity
	Metal binding	37	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	194	1	Manganese 2 By similarity
	Metal binding	233	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0AJS6 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 241D15FBF9C62B0F	FASTA	252	28,047
	10 20 30 40 50 60 MHAEFRTDRG RIRHHNEDNG GVFENKDNQP IVIVADGMGG HRAGDVASEM AVRLLSDAWK 70 80 90 100 110 120 ETTALLTAEE IETWLRKEIQ EVNKQIVLYA ESEMDLNGMG TTLVAAIMAK SQVVIANVGD 130 140 150 160 170 180 SRGYLLQNNT LRQLTEDHSL VHELLRTGEI SKEDAMNHPR KNILLRALGV EGKVEVDTFV 190 200 210 220 230 240 VPFQTTDTLL LCSDGLTNMV PETEMEDILK SKRSLSEKAD VFITKANSYG GEDNITVLLV 250 ERNLMQKGRD AS

References

[1]

"Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes." Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T. , Lampidis R., Kreft J., Goebel W., Chakraborty T. J. Bacteriol. 188:7405-7415(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35897 / DSM 20650 / SLCC5334.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM263198 Genomic DNA. Translation: CAK21258.1.
RefSeq	YP_850037.1. NC_008555.1.
3D structure databases
ProteinModelPortal	A0AJS6.
ModBase	Search...
Protein-protein interaction databases
STRING	386043.lwe1840.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK21258; CAK21258; lwe1840.
GeneID	4465993.
KEGG	lwe:lwe1840.
PATRIC	20330885. VBILisWel39304_1849.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000235782.
KO	K01090.
OMA	RIYRINS.
ProtClustDB	CLSK564625.
Enzyme and pathway databases
BioCyc	LWEL386043:GI5X-1859-MONOMER.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...

Entry information

Entry name

STP1_LISW6

Accession

Primary (citable) accession number: A0AJS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program