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A0AJD9

- GSA2_LISW6

UniProt

A0AJD9 - GSA2_LISW6

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2

Gene
hemL2, lwe1703
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLWEL386043:GI5X-1749-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2 (EC:5.4.3.8)
Short name:
GSA 2
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name:
GSA-AT 2
Gene namesi
Name:hemL2
Ordered Locus Names:lwe1703
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000779: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase 2UniRule annotationPRO_0000382337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386043.lwe1703.

Structurei

3D structure databases

ProteinModelPortaliA0AJD9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiPVVMERA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0AJD9-1 [UniParc]FASTAAdd to Basket

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MDHSMSKKLH DEALLHIVGG VNSPSRSNKG VGGGIPVTME RANGAYFYDV    50
DGNKYIDYLA AFGPIITGHA HPHITEAITK AAQNGVLYGT PTKHEITFAK 100
MLKEAIPSLE KVRFTNSGTE AVMTTIRVAR AYTGRDKIIK FAGCYHGHFD 150
LVLVEAGSGP STLGIPDSAG VTKSTAEEVI TVPFNDLASF KEALATWGNQ 200
VAAVLVEPIV GNFGMVEPAE GFLEAINELA HENGSLVIYD EVITAFRFMY 250
GGAQNYLGVI PDLTAMGKII GGGLPIGAYG GRIDIMEKVA PLGPAYQAGT 300
HAGNPASILS GIACLEVLQE EGLYDRFQKY GSMLKDGIEK AAVKHGIAVT 350
VNQIVGALTV YFTDEPVTNY AEAGATNGDL FGRFFKGMLE EGINLAPSKY 400
EAWFITSAHS EADILETIQA VDTVFAKMVQ DK 432
Length:432
Mass (Da):46,100
Last modified:November 28, 2006 - v1
Checksum:iC565CE0C4560B73C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM263198 Genomic DNA. Translation: CAK21121.1.
RefSeqiWP_011702485.1. NC_008555.1.
YP_849900.1. NC_008555.1.

Genome annotation databases

EnsemblBacteriaiCAK21121; CAK21121; lwe1703.
GeneIDi4465652.
KEGGilwe:lwe1703.
PATRICi20330605. VBILisWel39304_1713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM263198 Genomic DNA. Translation: CAK21121.1 .
RefSeqi WP_011702485.1. NC_008555.1.
YP_849900.1. NC_008555.1.

3D structure databases

ProteinModelPortali A0AJD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386043.lwe1703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK21121 ; CAK21121 ; lwe1703 .
GeneIDi 4465652.
KEGGi lwe:lwe1703.
PATRICi 20330605. VBILisWel39304_1713.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi PVVMERA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci LWEL386043:GI5X-1749-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes."
    Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.
    , Lampidis R., Kreft J., Goebel W., Chakraborty T.
    J. Bacteriol. 188:7405-7415(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35897 / DSM 20650 / SLCC5334.

Entry informationi

Entry nameiGSA2_LISW6
AccessioniPrimary (citable) accession number: A0AJD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: November 28, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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