A0AIE9 (GCST_LISW6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	lwe1363

Organism

Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334) [Complete proteome] [HAMAP]

Taxonomic identifier

386043 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_1000047678

Sequences

	Sequence		Length	Mass (Da)
	A0AIE9 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: A9F574B9B5AA67B8	FASTA	362	39,559
	10 20 30 40 50 60 MTELLKTPIH PLYAKYGAKT IDFGGWDLPV QFAGIKAEHE AVRTDAGLFD VSHMGEILVK 70 80 90 100 110 120 GPDSTSYLQY LLSNDIEKIK IGKAQYNIMC YENGGTVDDL VVYKKSETEY ILVVNAANTE 130 140 150 160 170 180 KDFEWMVQNV RGDVTVTNVS AEYGQLALQG PSAEKILSKL TDVDLSSISF FGFIEDVEVA 190 200 210 220 230 240 GVKTIISRSG YTGEDGFEIY MASADAGKVF EAILAEGVAP IGLGARDTLR LEAVLALYGQ 250 260 270 280 290 300 ELSKDITPLE AGLNFAVKLK KEADFIGKEA LIKQKEAGLT RKLVGIELIE RGIPRHDYPV 310 320 330 340 350 360 FLNDKEVGIV TSGTQSPTFG TNIGLALIDT AYAELGQELE VGIRNKKVKA KIVQTPFYKR AK

References

[1]

"Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes." Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S., Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O., Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T. , Lampidis R., Kreft J., Goebel W., Chakraborty T. J. Bacteriol. 188:7405-7415(2006) [PubMed: 16936040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35897 / DSM 20650 / SLCC5334.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM263198 Genomic DNA. Translation: CAK20781.1.
RefSeq	YP_849560.1. NC_008555.1.
3D structure databases
ProteinModelPortal	A0AIE9.
SMR	A0AIE9. Positions 4-357.
ModBase	Search...
Protein-protein interaction databases
STRING	A0AIE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4465193.
GenomeReviews	Gene locus lwe1363 in contig AM263198_GR.
KEGG	lwe:lwe1363.
NMPDR	fig|386043.6.peg.1319.
PATRIC	20329869. VBILisWel39304_1369.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	VINASNK.
PhylomeDB	A0AIE9.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	LWEL386043:LWE1363-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_LISW6

Accession

Primary (citable) accession number: A0AIE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 28, 2006
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program