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Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1518)/N6-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei31S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei56S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei77S-adenosyl-L-methionineUniRule annotation1
Binding sitei102S-adenosyl-L-methionineUniRule annotation1
Binding sitei128S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLWEL386043:G1GJF-157-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:lwe0157
OrganismiListeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Taxonomic identifieri386043 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000779 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000566331 – 295Ribosomal RNA small subunit methyltransferase AAdd BLAST295

Interactioni

Protein-protein interaction databases

STRINGi386043.lwe0157

Structurei

3D structure databases

ProteinModelPortaliA0AEZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D1X Bacteria
COG0030 LUCA
HOGENOMiHOG000227962
KOiK02528
OMAiKRFGQHW
OrthoDBiPOG091H02E3

Family and domain databases

Gene3Di1.10.8.100, 1 hit
HAMAPiMF_00607 16SrRNA_methyltr_A, 1 hit
InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR023165 rRNA_Ade_diMease-like
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

A0AEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDIATPGK TTEILKKYGF LFKKSLGQNF LIDSNILTRI TDTAGISKET
60 70 80 90 100
NVIEIGPGIG ALTEQLAKTA NEVVAFEIDQ RLLPILDDTL SAYNNIQVVH
110 120 130 140 150
GDVLKADVEE VITQQFSKSE LPLKIVANLP YYVTTPIILK LLHDNIPADS
160 170 180 190 200
MTFMLQKEVA DRISAVPSTK SYGSLTIAIQ FYMEAELAFI VPKTVFMPQP
210 220 230 240 250
NVDSAVIHLK RRKEPLAKVN DEEFFFEVTR ASFAQRRKTL WNNLASKFPA
260 270 280 290
LKPRKDELVE GLNAIGIDLI RRGETLDIPE FAKLSNFLAD FLEEK
Length:295
Mass (Da):33,045
Last modified:November 28, 2006 - v1
Checksum:i4570A4C2BC9D90DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM263198 Genomic DNA Translation: CAK19575.1
RefSeqiWP_011701026.1, NC_008555.1

Genome annotation databases

EnsemblBacteriaiCAK19575; CAK19575; lwe0157
KEGGilwe:lwe0157

Similar proteinsi

Entry informationi

Entry nameiRSMA_LISW6
AccessioniPrimary (citable) accession number: A0AEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 28, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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