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Protein
Submitted name:

Cyclooxygenase 1

Gene

ptgs1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cyclooxygenase pathway Source: InterPro
  2. inflammatory response Source: InterPro
  3. regulation of blood pressure Source: InterPro
  4. response to oxidative stress Source: InterPro
Complete GO annotation...

Protein family/group databases

PeroxiBasei4271. XlPGHS01.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 1Imported
Gene namesi
Name:ptgs1Imported
Synonyms:COX1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-995318. ptgs1.

Structurei

3D structure databases

ProteinModelPortaliA0A9J3.
SMRiA0A9J3. Positions 25-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
KOiK00509.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A9J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLCLTMLF MIVTSSYSLE VSTKVNPCCY YPCQHKGVCV RFEMEEYQCD
60 70 80 90 100
CTRTGYYGTN CTIPEWWTKF RELIRPSPAF YHYILTRFKW FWDIINSTFI
110 120 130 140 150
RDFIVRLVLT VRSNLIPSPP TYNSEYGYIS WEAYSNVSYF TRVLPPVPHD
160 170 180 190 200
CPTPMGTKGK KELPDATFLV ETFLKREKFI PDPQGTNLLF AFFAQHFTHQ
210 220 230 240 250
FFKTYGRMGR GFIKGFGHGV DLSHIYGDSL ERQQILRLFK DGKLKYQIIN
260 270 280 290 300
GETYPPTVVE APVHMIYPEN VPKEKQFAVG QEVFGLLPGL MMYATLWLRE
310 320 330 340 350
HNRVCDVLKK EHPTWDDEQL FQTTRLILIG ETIKIVIEDY VQHLSGYYLK
360 370 380 390 400
LKFDPELLFG VQFQYRNRIA VEFNQLYHWH PLMPEKFKII EDEFGYSSFI
410 420 430 440 450
YNTSIILDYG VEALVESFTK QIAGKIGGGK NHPPSLLKVA AGVIEESRNL
460 470 480 490 500
RLQPFNEYRK RFGLKAYKSF RDLTGEEKMA AQLEEFYGDI DALEFYVGLL
510 520 530 540 550
LEKPNPNSIF GESMVEIGAP FPLKGLLGNP ICSPEYWKPS TFGGETGFNI
560 570 580
VKTASIQKLV CLNVKTCPFV AFHVPDVLPT LKKSDEL
Length:587
Mass (Da):67,792
Last modified:November 28, 2006 - v1
Checksum:i71CC006B9B652FDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB278691 mRNA. Translation: BAF36493.1.
RefSeqiNP_001091389.1. NM_001097920.1.
UniGeneiXl.6116.

Genome annotation databases

GeneIDi100037245.
KEGGixla:100037245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB278691 mRNA. Translation: BAF36493.1.
RefSeqiNP_001091389.1. NM_001097920.1.
UniGeneiXl.6116.

3D structure databases

ProteinModelPortaliA0A9J3.
SMRiA0A9J3. Positions 25-576.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei4271. XlPGHS01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100037245.
KEGGixla:100037245.

Organism-specific databases

CTDi5742.
XenbaseiXB-GENE-995318. ptgs1.

Phylogenomic databases

HOVERGENiHBG000366.
KOiK00509.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of cyclooxygenase-1 and 2 genes during ovulation in the ovarian follicles of Xenopus."
    Kumakura N., Sena J.A., Gott M.D., Patino R., Liu Z.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.

Entry informationi

Entry nameiA0A9J3_XENLA
AccessioniPrimary (citable) accession number: A0A9J3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.