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A0A5B9

- TRBC2_HUMAN

UniProt

A0A5B9 - TRBC2_HUMAN

Protein

T-cell receptor beta-2 chain C region

Gene

TRBC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell receptor beta-2 chain C region
    Gene namesi
    Name:TRBC2
    Synonyms:TCRBC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:12157. TRBC2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 178›178T-cell receptor beta-2 chain C regionPRO_0000393471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 95PROSITE-ProRule annotation
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA0A5B9.
    PRIDEiA0A5B9.

    Expressioni

    Gene expression databases

    BgeeiA0A5B9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000417300.

    Structurei

    Secondary structure

    1
    178
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 43
    Beta strandi9 – 135
    Helixi17 – 237
    Beta strandi24 – 3815
    Beta strandi40 – 467
    Beta strandi49 – 513
    Beta strandi55 – 573
    Beta strandi62 – 654
    Beta strandi68 – 703
    Beta strandi73 – 8210
    Helixi83 – 864
    Beta strandi92 – 998
    Beta strandi104 – 1063
    Beta strandi110 – 1123
    Beta strandi116 – 12510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BNQX-ray1.70E1-129[»]
    2EYRX-ray2.40B1-129[»]
    2EYSX-ray2.21B1-129[»]
    2EYTX-ray2.60B/D1-129[»]
    3KXFX-ray3.10E/H/O/P1-129[»]
    3O6FX-ray2.80D/H1-130[»]
    3O8XX-ray2.74D13-128[»]
    3O9WX-ray2.80D13-128[»]
    3QUXX-ray2.91D13-128[»]
    3T0EX-ray4.00D1-130[»]
    3TA3X-ray2.70D13-128[»]
    3TVMX-ray2.80D/H13-128[»]
    ProteinModelPortaliA0A5B9.
    SMRiA0A5B9. Positions 1-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA0A5B9.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei145 – 16723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 117110Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46033.
    HOVERGENiHBG017899.
    OMAiNISASAX.
    PhylomeDBiA0A5B9.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0A5B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    DLKNVFPPEV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE    50
    VHSGVSTDPQ PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY 100
    GLSENDEWTQ DRAKPVTQIV SAEAWGRADC GFTSESYQQG VLSATILYEI 150
    LLGKATLYAV LVSALVLMAM VKRKDSRG 178
    Length:178
    Mass (Da):19,969
    Last modified:November 28, 2006 - v1
    Checksum:iFADB2A916ADC7E93
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12888 Genomic DNA. Translation: AAA60662.1.
    L36092 Genomic DNA. Translation: AAC80214.1.
    CH471198 Genomic DNA. Translation: EAW51905.1.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12888 Genomic DNA. Translation: AAA60662.1 .
    L36092 Genomic DNA. Translation: AAC80214.1 .
    CH471198 Genomic DNA. Translation: EAW51905.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BNQ X-ray 1.70 E 1-129 [» ]
    2EYR X-ray 2.40 B 1-129 [» ]
    2EYS X-ray 2.21 B 1-129 [» ]
    2EYT X-ray 2.60 B/D 1-129 [» ]
    3KXF X-ray 3.10 E/H/O/P 1-129 [» ]
    3O6F X-ray 2.80 D/H 1-130 [» ]
    3O8X X-ray 2.74 D 13-128 [» ]
    3O9W X-ray 2.80 D 13-128 [» ]
    3QUX X-ray 2.91 D 13-128 [» ]
    3T0E X-ray 4.00 D 1-130 [» ]
    3TA3 X-ray 2.70 D 13-128 [» ]
    3TVM X-ray 2.80 D/H 13-128 [» ]
    ProteinModelPortali A0A5B9.
    SMRi A0A5B9. Positions 1-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000417300.

    Proteomic databases

    PaxDbi A0A5B9.
    PRIDEi A0A5B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC07P142727.
    H-InvDB HIX0114733.
    HGNCi HGNC:12157. TRBC2.
    MIMi 615445. gene.
    neXtProti NX_A0A5B9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46033.
    HOVERGENi HBG017899.
    OMAi NISASAX.
    PhylomeDBi A0A5B9.

    Miscellaneous databases

    EvolutionaryTracei A0A5B9.
    PROi A0A5B9.
    SOURCEi Search...

    Gene expression databases

    Bgeei A0A5B9.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
      Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
      Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
      Rowen L., Koop B.F., Hood L.
      Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTRBC2_HUMAN
    AccessioniPrimary (citable) accession number: A0A5B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3