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Protein

T-cell receptor beta-2 chain C region

Gene

TRBC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-2 chain C region
Gene namesi
Name:TRBC2
Synonyms:TCRBC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12157 TRBC2
MIMi615445 gene
neXtProtiNX_A0A5B9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28638

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000393471‹1 – 178T-cell receptor beta-2 chain C regionAdd BLAST›178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 95PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA0A5B9

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi9 – 14Combined sources6
Helixi17 – 23Combined sources7
Beta strandi24 – 38Combined sources15
Beta strandi40 – 46Combined sources7
Beta strandi49 – 51Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi62 – 65Combined sources4
Beta strandi68 – 70Combined sources3
Beta strandi73 – 82Combined sources10
Helixi83 – 86Combined sources4
Beta strandi92 – 99Combined sources8
Beta strandi104 – 106Combined sources3
Beta strandi110 – 112Combined sources3
Beta strandi116 – 125Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-129[»]
1BD2X-ray2.50E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D13-128[»]
3O9WX-ray2.80D13-128[»]
3QUXX-ray2.91D13-128[»]
3T0EX-ray4.00D1-130[»]
3TA3X-ray2.70D13-128[»]
3TVMX-ray2.80D/H13-128[»]
4C56X-ray2.90B/H1-129[»]
4MVBX-ray3.09D1-129[»]
4MXQX-ray2.60D1-129[»]
4N0CX-ray2.90D/H1-129[»]
4N5EX-ray3.06D1-129[»]
4NHUX-ray2.90B/D1-147[»]
4ONHX-ray3.01B1-129[»]
4P4KX-ray2.80D/H1-129[»]
4UDTX-ray1.35B1-129[»]
4UDUX-ray2.50B1-129[»]
4WW1X-ray1.38B1-129[»]
4WW2X-ray2.48B1-129[»]
4WWKX-ray3.10B1-129[»]
4Y16X-ray2.60D13-128[»]
4Y2DX-ray3.05D/H13-128[»]
4Y4FX-ray3.19D/H13-128[»]
4Y4HX-ray3.10D/H13-128[»]
4Y4KX-ray2.90D13-128[»]
4ZAKX-ray2.82D18-128[»]
5BRZX-ray2.62E1-129[»]
5BS0X-ray2.40E1-129[»]
5C07X-ray2.11E/J1-129[»]
5C08X-ray2.33E/J1-129[»]
5C09X-ray2.48E/J1-129[»]
5C0AX-ray2.46E/J1-129[»]
5C0BX-ray2.03E/J1-129[»]
5C0CX-ray1.97E/J1-129[»]
5EU6X-ray2.02E1-129[»]
5FK9X-ray3.10B1-129[»]
5FKAX-ray2.40B1-129[»]
5HHMX-ray2.50E/J1-129[»]
5HHOX-ray2.95E1-129[»]
5HYJX-ray3.06E/J1-129[»]
5KS9X-ray2.55F/H1-129[»]
5KSAX-ray2.00D1-129[»]
5KSBX-ray2.90F/H1-129[»]
ProteinModelPortaliA0A5B9
SMRiA0A5B9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0A5B9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 117Ig-likeAdd BLAST110

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017899
InParanoidiA0A5B9
PhylomeDBiA0A5B9

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A5B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLKNVFPPEV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE
60 70 80 90 100
VHSGVSTDPQ PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY
110 120 130 140 150
GLSENDEWTQ DRAKPVTQIV SAEAWGRADC GFTSESYQQG VLSATILYEI
160 170
LLGKATLYAV LVSALVLMAM VKRKDSRG
Length:178
Mass (Da):19,969
Last modified:November 28, 2006 - v1
Checksum:iFADB2A916ADC7E93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12888 Genomic DNA Translation: AAA60662.1
L36092 Genomic DNA Translation: AAC80214.1
CH471198 Genomic DNA Translation: EAW51905.1

Similar proteinsi

Entry informationi

Entry nameiTRBC2_HUMAN
AccessioniPrimary (citable) accession number: A0A5B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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