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A0A5B9 (TRBC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell receptor beta-2 chain C region
Gene names
Name:TRBC2
Synonyms:TCRBC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 178›178T-cell receptor beta-2 chain C region
PRO_0000393471

Regions

Transmembrane145 – 16723Helical; Potential
Domain8 – 117110Ig-like

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 95 By similarity

Experimental info

Non-terminal residue11

Secondary structure

............................. 178
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A0A5B9 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: FADB2A916ADC7E93

FASTA17819,969
        10         20         30         40         50         60 
DLKNVFPPEV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE VHSGVSTDPQ 

        70         80         90        100        110        120 
PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY GLSENDEWTQ DRAKPVTQIV 

       130        140        150        160        170 
SAEAWGRADC GFTSESYQQG VLSATILYEI LLGKATLYAV LVSALVLMAM VKRKDSRG 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
Rowen L., Koop B.F., Hood L.
Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12888 Genomic DNA. Translation: AAA60662.1.
L36092 Genomic DNA. Translation: AAC80214.1.
CH471198 Genomic DNA. Translation: EAW51905.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BNQX-ray1.70E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D1-128[»]
3O9WX-ray2.80D1-128[»]
ProteinModelPortalA0A5B9.
SMRA0A5B9. Positions 1-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000417300.

Proteomic databases

PaxDbA0A5B9.
PRIDEA0A5B9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC07P142727.
H-InvDBHIX0114733.
HGNCHGNC:12157. TRBC2.
MIM615445. gene.
neXtProtNX_A0A5B9.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46033.
HOVERGENHBG017899.
OMANISASAX.
PhylomeDBA0A5B9.

Gene expression databases

BgeeA0A5B9.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceA0A5B9.
PROA0A5B9.
SOURCESearch...

Entry information

Entry nameTRBC2_HUMAN
AccessionPrimary (citable) accession number: A0A5B9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM