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Protein

T-cell receptor beta-2 chain C region

Gene

TRBC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-2 chain C region
Gene namesi
Name:TRBC2
Synonyms:TCRBC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12157. TRBC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei145 – 16723HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 178›178T-cell receptor beta-2 chain C regionPRO_0000393471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 95PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA0A5B9.
PRIDEiA0A5B9.

Expressioni

Gene expression databases

BgeeiA0A5B9.

Structurei

Secondary structure

1
178
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 43Combined sources
Beta strandi9 – 135Combined sources
Helixi17 – 237Combined sources
Beta strandi24 – 3815Combined sources
Beta strandi40 – 467Combined sources
Beta strandi49 – 513Combined sources
Beta strandi55 – 573Combined sources
Beta strandi62 – 654Combined sources
Beta strandi66 – 705Combined sources
Beta strandi73 – 8210Combined sources
Helixi83 – 864Combined sources
Beta strandi92 – 998Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi116 – 12510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BNQX-ray1.70E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D13-128[»]
3O9WX-ray2.80D13-128[»]
3QUXX-ray2.91D13-128[»]
3T0EX-ray4.00D1-130[»]
3TA3X-ray2.70D13-128[»]
3TVMX-ray2.80D/H13-128[»]
4C56X-ray2.90B/H1-129[»]
4ONHX-ray3.01B1-129[»]
ProteinModelPortaliA0A5B9.
SMRiA0A5B9. Positions 1-129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0A5B9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 117110Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46033.
HOVERGENiHBG017899.
InParanoidiA0A5B9.
OMAiDTGCDIF.
PhylomeDBiA0A5B9.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A5B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLKNVFPPEV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE
60 70 80 90 100
VHSGVSTDPQ PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY
110 120 130 140 150
GLSENDEWTQ DRAKPVTQIV SAEAWGRADC GFTSESYQQG VLSATILYEI
160 170
LLGKATLYAV LVSALVLMAM VKRKDSRG
Length:178
Mass (Da):19,969
Last modified:November 28, 2006 - v1
Checksum:iFADB2A916ADC7E93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12888 Genomic DNA. Translation: AAA60662.1.
L36092 Genomic DNA. Translation: AAC80214.1.
CH471198 Genomic DNA. Translation: EAW51905.1.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12888 Genomic DNA. Translation: AAA60662.1.
L36092 Genomic DNA. Translation: AAC80214.1.
CH471198 Genomic DNA. Translation: EAW51905.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BNQX-ray1.70E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D13-128[»]
3O9WX-ray2.80D13-128[»]
3QUXX-ray2.91D13-128[»]
3T0EX-ray4.00D1-130[»]
3TA3X-ray2.70D13-128[»]
3TVMX-ray2.80D/H13-128[»]
4C56X-ray2.90B/H1-129[»]
4ONHX-ray3.01B1-129[»]
ProteinModelPortaliA0A5B9.
SMRiA0A5B9. Positions 1-129.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA0A5B9.
PRIDEiA0A5B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC07P142792.
H-InvDBHIX0114733.
HGNCiHGNC:12157. TRBC2.
MIMi615445. gene.
neXtProtiNX_A0A5B9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46033.
HOVERGENiHBG017899.
InParanoidiA0A5B9.
OMAiDTGCDIF.
PhylomeDBiA0A5B9.

Miscellaneous databases

EvolutionaryTraceiA0A5B9.
PROiA0A5B9.
SOURCEiSearch...

Gene expression databases

BgeeiA0A5B9.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
    Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
    Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
    Rowen L., Koop B.F., Hood L.
    Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTRBC2_HUMAN
AccessioniPrimary (citable) accession number: A0A5B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 28, 2006
Last modified: June 24, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.