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Protein

T-cell receptor beta-2 chain C region

Gene

TRBC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:G66-31613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-2 chain C region
Gene namesi
Name:TRBC2
Synonyms:TCRBC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12157. TRBC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000393471‹1 – 178T-cell receptor beta-2 chain C regionAdd BLAST›178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 95PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA0A5B9.

Expressioni

Gene expression databases

BgeeiENSG00000211772.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi9 – 14Combined sources6
Helixi17 – 23Combined sources7
Beta strandi24 – 38Combined sources15
Beta strandi40 – 46Combined sources7
Beta strandi49 – 51Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi62 – 65Combined sources4
Beta strandi68 – 70Combined sources3
Beta strandi73 – 82Combined sources10
Helixi83 – 86Combined sources4
Beta strandi92 – 99Combined sources8
Beta strandi104 – 106Combined sources3
Beta strandi110 – 112Combined sources3
Beta strandi116 – 125Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-129[»]
1BD2X-ray2.50E1-129[»]
2BNQX-ray1.70E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D13-128[»]
3O9WX-ray2.80D13-128[»]
3QUXX-ray2.91D13-128[»]
3T0EX-ray4.00D1-130[»]
3TA3X-ray2.70D13-128[»]
3TVMX-ray2.80D/H13-128[»]
4C56X-ray2.90B/H1-129[»]
4MVBX-ray3.09D1-129[»]
4MXQX-ray2.60D1-129[»]
4N0CX-ray2.90D/H1-129[»]
4N5EX-ray3.06D1-129[»]
4NHUX-ray2.90B/D1-147[»]
4ONHX-ray3.01B1-129[»]
4P4KX-ray2.80D/H1-129[»]
4UDTX-ray1.35B1-129[»]
4UDUX-ray2.50B1-129[»]
4WW1X-ray1.38B1-129[»]
4WW2X-ray2.48B1-129[»]
4WWKX-ray3.10B1-129[»]
4Y16X-ray2.60D13-128[»]
4Y2DX-ray3.05D/H13-128[»]
4Y4FX-ray3.19D/H13-128[»]
4Y4HX-ray3.10D/H13-128[»]
4Y4KX-ray2.90D13-128[»]
4ZAKX-ray2.82D18-128[»]
4ZEZX-ray2.40H/J1-129[»]
5BRZX-ray2.62E1-129[»]
5BS0X-ray2.40E1-129[»]
5C07X-ray2.11E/J1-129[»]
5C08X-ray2.33E/J1-129[»]
5C09X-ray2.48E/J1-129[»]
5C0AX-ray2.46E/J1-129[»]
5C0BX-ray2.03E/J1-129[»]
5C0CX-ray1.97E/J1-129[»]
5EU6X-ray2.02E1-129[»]
5FK9X-ray3.10B1-129[»]
5FKAX-ray2.40B1-129[»]
5HHMX-ray2.50E/J1-129[»]
5HHOX-ray2.95E1-129[»]
5HYJX-ray3.06E/J1-129[»]
5KS9X-ray2.55F/H1-129[»]
5KSAX-ray2.00D1-129[»]
5KSBX-ray2.90F/H1-129[»]
ProteinModelPortaliA0A5B9.
SMRiA0A5B9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0A5B9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 117Ig-likeAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017899.
InParanoidiA0A5B9.
PhylomeDBiA0A5B9.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A5B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLKNVFPPEV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE
60 70 80 90 100
VHSGVSTDPQ PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY
110 120 130 140 150
GLSENDEWTQ DRAKPVTQIV SAEAWGRADC GFTSESYQQG VLSATILYEI
160 170
LLGKATLYAV LVSALVLMAM VKRKDSRG
Length:178
Mass (Da):19,969
Last modified:November 28, 2006 - v1
Checksum:iFADB2A916ADC7E93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12888 Genomic DNA. Translation: AAA60662.1.
L36092 Genomic DNA. Translation: AAC80214.1.
CH471198 Genomic DNA. Translation: EAW51905.1.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12888 Genomic DNA. Translation: AAA60662.1.
L36092 Genomic DNA. Translation: AAC80214.1.
CH471198 Genomic DNA. Translation: EAW51905.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-129[»]
1BD2X-ray2.50E1-129[»]
2BNQX-ray1.70E1-129[»]
2EYRX-ray2.40B1-129[»]
2EYSX-ray2.21B1-129[»]
2EYTX-ray2.60B/D1-129[»]
3KXFX-ray3.10E/H/O/P1-129[»]
3O6FX-ray2.80D/H1-130[»]
3O8XX-ray2.74D13-128[»]
3O9WX-ray2.80D13-128[»]
3QUXX-ray2.91D13-128[»]
3T0EX-ray4.00D1-130[»]
3TA3X-ray2.70D13-128[»]
3TVMX-ray2.80D/H13-128[»]
4C56X-ray2.90B/H1-129[»]
4MVBX-ray3.09D1-129[»]
4MXQX-ray2.60D1-129[»]
4N0CX-ray2.90D/H1-129[»]
4N5EX-ray3.06D1-129[»]
4NHUX-ray2.90B/D1-147[»]
4ONHX-ray3.01B1-129[»]
4P4KX-ray2.80D/H1-129[»]
4UDTX-ray1.35B1-129[»]
4UDUX-ray2.50B1-129[»]
4WW1X-ray1.38B1-129[»]
4WW2X-ray2.48B1-129[»]
4WWKX-ray3.10B1-129[»]
4Y16X-ray2.60D13-128[»]
4Y2DX-ray3.05D/H13-128[»]
4Y4FX-ray3.19D/H13-128[»]
4Y4HX-ray3.10D/H13-128[»]
4Y4KX-ray2.90D13-128[»]
4ZAKX-ray2.82D18-128[»]
4ZEZX-ray2.40H/J1-129[»]
5BRZX-ray2.62E1-129[»]
5BS0X-ray2.40E1-129[»]
5C07X-ray2.11E/J1-129[»]
5C08X-ray2.33E/J1-129[»]
5C09X-ray2.48E/J1-129[»]
5C0AX-ray2.46E/J1-129[»]
5C0BX-ray2.03E/J1-129[»]
5C0CX-ray1.97E/J1-129[»]
5EU6X-ray2.02E1-129[»]
5FK9X-ray3.10B1-129[»]
5FKAX-ray2.40B1-129[»]
5HHMX-ray2.50E/J1-129[»]
5HHOX-ray2.95E1-129[»]
5HYJX-ray3.06E/J1-129[»]
5KS9X-ray2.55F/H1-129[»]
5KSAX-ray2.00D1-129[»]
5KSBX-ray2.90F/H1-129[»]
ProteinModelPortaliA0A5B9.
SMRiA0A5B9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A5B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi28638.
GeneCardsiTRBC2.
H-InvDBHIX0114733.
HGNCiHGNC:12157. TRBC2.
MIMi615445. gene.
neXtProtiNX_A0A5B9.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017899.
InParanoidiA0A5B9.
PhylomeDBiA0A5B9.

Enzyme and pathway databases

BioCyciZFISH:G66-31613-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA0A5B9.
PROiA0A5B9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211772.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRBC2_HUMAN
AccessioniPrimary (citable) accession number: A0A5B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.