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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-2777-MONOMER
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:GSU2537
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000684911 – 635Biosynthetic arginine decarboxylaseAdd BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA0A4W3

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU2537

Structurei

3D structure databases

ProteinModelPortaliA0A4W3
SMRiA0A4W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 292Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
InParanoidiA0A4W3
KOiK01585
OMAiLFPIMPI
OrthoDBiPOG091H04NG

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A4W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERWSINESA KIYNLPNWGA DLFSINKKGN VCVHPSPTSK HSIDLRALVD
60 70 80 90 100
DLIKRKIKPP ILLRFMDVLQ GRIASINRVF KNAIDENDYP ATYQTFYPIK
110 120 130 140 150
VNQQRQVVEA IAKFGKRYNI GLEVGSKPEL VIGISFATGN GIPIICNGYK
160 170 180 190 200
DTEYIETVLY ATKIGYDITI VVEKMFELEK IIALSKKTGI KPKLGIRVKL
210 220 230 240 250
SSKGTGKWAT SGGEDAKFGL RMSEIIAAIG LLEQNDLLDR VKLLHFHIGS
260 270 280 290 300
QITKIDKIKS ALIEGTRIYA EMRKLGVGIR YVDIGGGLGV DYDGSKSSYF
310 320 330 340 350
SSVNYSIEEY ANDVIYQIKN ICEDAGVECP NIISESGRAT AAHYSVLVTN
360 370 380 390 400
LLNTNTSNAM PDFEETLNGT EKLAPTVKKL VDIYKSIDRY SLREDYHDTV
410 420 430 440 450
QLIQEAVSLF NLGYLTLNER AMAEWLHGKI LRKINGIVEK IKPIPEELQN
460 470 480 490 500
FQLSLRQTYF ANFSLFQSIP DSWAIDQLFP IVPIQRLNQK PDVMASIADI
510 520 530 540 550
TCDSDGEITS FVGENGRTKY LPLHKMRKDE DYFVGFFLIG AYQEILGDMH
560 570 580 590 600
NLFGDTNAVH VTFNKKTGYK IDTVIHGDAT WESLKYVQYK GPEILKHVRD
610 620 630
TLEKDVALRK VTIEESSHFL ELLDRTLLGY TYLGE
Length:635
Mass (Da):71,637
Last modified:November 28, 2006 - v1
Checksum:i5688D3984B1DAF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR35910.1
RefSeqiNP_953583.1, NC_002939.5
WP_010943173.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR35910; AAR35910; GSU2537
GeneIDi2687789
KEGGigsu:GSU2537
PATRICifig|243231.5.peg.2566

Similar proteinsi

Entry informationi

Entry nameiSPEA_GEOSL
AccessioniPrimary (citable) accession number: A0A4W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health