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A0A4W3

- SPEA_GEOSL

UniProt

A0A4W3 - SPEA_GEOSL

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Protein

Biosynthetic arginine decarboxylase

Gene
speA, GSU2537
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGSUL243231:GH27-2570-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:GSU2537
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylaseUniRule annotationPRO_1000068491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU2537.

Structurei

3D structure databases

ProteinModelPortaliA0A4W3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiDSEDMVE.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A4W3-1 [UniParc]FASTAAdd to Basket

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MERWSINESA KIYNLPNWGA DLFSINKKGN VCVHPSPTSK HSIDLRALVD    50
DLIKRKIKPP ILLRFMDVLQ GRIASINRVF KNAIDENDYP ATYQTFYPIK 100
VNQQRQVVEA IAKFGKRYNI GLEVGSKPEL VIGISFATGN GIPIICNGYK 150
DTEYIETVLY ATKIGYDITI VVEKMFELEK IIALSKKTGI KPKLGIRVKL 200
SSKGTGKWAT SGGEDAKFGL RMSEIIAAIG LLEQNDLLDR VKLLHFHIGS 250
QITKIDKIKS ALIEGTRIYA EMRKLGVGIR YVDIGGGLGV DYDGSKSSYF 300
SSVNYSIEEY ANDVIYQIKN ICEDAGVECP NIISESGRAT AAHYSVLVTN 350
LLNTNTSNAM PDFEETLNGT EKLAPTVKKL VDIYKSIDRY SLREDYHDTV 400
QLIQEAVSLF NLGYLTLNER AMAEWLHGKI LRKINGIVEK IKPIPEELQN 450
FQLSLRQTYF ANFSLFQSIP DSWAIDQLFP IVPIQRLNQK PDVMASIADI 500
TCDSDGEITS FVGENGRTKY LPLHKMRKDE DYFVGFFLIG AYQEILGDMH 550
NLFGDTNAVH VTFNKKTGYK IDTVIHGDAT WESLKYVQYK GPEILKHVRD 600
TLEKDVALRK VTIEESSHFL ELLDRTLLGY TYLGE 635
Length:635
Mass (Da):71,637
Last modified:November 28, 2006 - v1
Checksum:i5688D3984B1DAF99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35910.1.
RefSeqiNP_953583.1. NC_002939.5.
WP_010943173.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35910; AAR35910; GSU2537.
GeneIDi2687789.
KEGGigsu:GSU2537.
PATRICi22027923. VBIGeoSul17553_2566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35910.1 .
RefSeqi NP_953583.1. NC_002939.5.
WP_010943173.1. NC_002939.5.

3D structure databases

ProteinModelPortali A0A4W3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU2537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR35910 ; AAR35910 ; GSU2537 .
GeneIDi 2687789.
KEGGi gsu:GSU2537.
PATRICi 22027923. VBIGeoSul17553_2566.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi DSEDMVE.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci GSUL243231:GH27-2570-MONOMER.

Family and domain databases

Gene3Di 3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiSPEA_GEOSL
AccessioniPrimary (citable) accession number: A0A4W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 28, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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