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Protein
Submitted name:

MDM2 proto-oncogene

Gene

MDM2

Organism
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
MDM2 proto-oncogeneImported
Gene namesi
Name:MDM2Imported
OrganismiRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)Imported
Taxonomic identifieri61621 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
Proteomesi
  • UP000233180 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 277RanBP2-typeInterPro annotationAdd BLAST30
Domaini387 – 428RING-typeInterPro annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 134Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063539

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15 PTHR13844:SF15, 2 hits
PfamiView protein in Pfam
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500700 MDM2, 2 hits
PIRSF006748 p53_MDM_2/4, 2 hits
SUPFAMiSSF47592 SSF47592, 2 hits
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6KDW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEVISDSFSF LSESSDSGTS VSENRCHLEG GSDQKDLVQE LQEEKPSSSH
110 120 130 140 150
LVSRPSTSSR RRAISETEEN SDELSGERQR KRHKSDSISL SFDESLALCV
160 170 180 190 200
IREICCERSS SSESTGTPSN PDLDAGVSEH SGDWLDQDSV SDQFSVEFEV
210 220 230 240 250
ESLDSEDYSL SEEAQELSDE DDEVYRVTVY QAGESDTDSF EEDPEISLAD
260 270 280 290 300
YWKCTSCNEM NPPLPSHCNR CWALRENWLP EDKGKDKGEI SEKAKLENST
310 320 330 340 350
QAEEGFDVPD CKKTIVNDSK ESCVEENDDK ITQASQSQES EDYSQPSTSS
360 370 380 390 400
SIIYSSQEDV KEFEREETQD KEESVESSLP LNAIEPCVIC QGRPKNGCIV
410 420 430 440
HGKTGHLMAC FTCAKKLKKR NKPCPVCRQP IQMIVLTYFP
Length:440
Mass (Da):49,032
Last modified:March 28, 2018 - v1
Checksum:i29A1031D88EC4F32
GO

Genome annotation databases

EnsembliENSRBIT00000033060; ENSRBIP00000009444; ENSRBIG00000028561

Similar proteinsi

Entry informationi

Entry nameiA0A2K6KDW0_RHIBE
AccessioniPrimary (citable) accession number: A0A2K6KDW0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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