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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1D

Organism
Colobus angolensis palliatus (Peters' Angolan colobus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1DImported
OrganismiColobus angolensis palliatus (Peters' Angolan colobus)Imported
Taxonomic identifieri336983 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus
Proteomesi
  • UP000233080 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei154 – 171HelicalSequence analysisAdd BLAST18
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei223 – 242HelicalSequence analysisAdd BLAST20
Transmembranei295 – 318HelicalSequence analysisAdd BLAST24
Transmembranei374 – 395HelicalSequence analysisAdd BLAST22
Transmembranei407 – 429HelicalSequence analysisAdd BLAST23
Transmembranei547 – 565HelicalSequence analysisAdd BLAST19
Transmembranei585 – 608HelicalSequence analysisAdd BLAST24
Transmembranei677 – 696HelicalSequence analysisAdd BLAST20
Transmembranei749 – 776HelicalSequence analysisAdd BLAST28
Transmembranei911 – 929HelicalSequence analysisAdd BLAST19
Transmembranei949 – 969HelicalSequence analysisAdd BLAST21
Transmembranei981 – 1007HelicalSequence analysisAdd BLAST27
Transmembranei1027 – 1057HelicalSequence analysisAdd BLAST31
Transmembranei1154 – 1179HelicalSequence analysisAdd BLAST26
Transmembranei1233 – 1251HelicalSequence analysisAdd BLAST19
Transmembranei1263 – 1283HelicalSequence analysisAdd BLAST21
Transmembranei1358 – 1376HelicalSequence analysisAdd BLAST19
Transmembranei1450 – 1473HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1607 – 1641Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili779 – 810Sequence analysisAdd BLAST32
Coiled coili1568 – 1588Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR005452 LVDCC_a1dsu
IPR014873 VDCC_a1su_IQ
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF139 PTHR10037:SF139, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01636 LVDCCALPHA1D
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K5H750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMNLPTFSS DLILLKNTIY QEIDARYKGK VISEAETKGY FSLAFGEANY
60 70 80 90 100
ARGTRLPLSG EGPTSQPNSS KQTVLSWQAA IDAARQAKAA QTMSTSAPPP
110 120 130 140 150
VGSLSQRKRQ QYAKSKKQGN SSNSRPARAL FCLSLNNPIR RACISIVEWK
160 170 180 190 200
PFDIFILLAI FANCVALAIY IPFPEDDSNS TNHNLEKVEY AFLIIFTVET
210 220 230 240 250
FLKIIAYGLL LHPNAYVRNG WNLLDFVIVI VGLFSVILEQ LTKETEGGNH
260 270 280 290 300
SSGKSGGFDV KALRAFRVLR PLRLVSGVPS LQVVLNSIIK AMVPLLHIAL
310 320 330 340 350
LVLFVIIIYA IIGLELFIGK MHKTCFFADS DIVAEEDPAP CAFSGNGRQC
360 370 380 390 400
TANGTECRSG WVGPNGGITN FDNFAFAMLT VFQCITMEGW TDVLYWVNDA
410 420 430 440 450
IGWEWPWVYF VSLIILGSFF VLNLVLGVLS GEFSKEREKA KARGDFQKLR
460 470 480 490 500
EKQQLEEDLK GYLDWITQAE DIDPENEEEG GEEGKRNTSM PTSETESVNT
510 520 530 540 550
ENVSGEGETR GCCGSLCQAI SKSKLSRRWR RWNRFNRRRC RAAVKSVTFY
560 570 580 590 600
WLVIVLVFLN TLTISSEHYN QPDWLTQIQD IANKVLLALF TCEMLVKMYS
610 620 630 640 650
LGLQAYFVSL FNRFDCFVVC GGITETILVE LEIMSPLGIS VFRCVRLLRI
660 670 680 690 700
FKVTRHWTSL SNLVASLLNS MKSIASLLLL LFLFIIIFSL LGMQLFGGKF
710 720 730 740 750
NFDETQTKRS TFDNFPQALL TVFQILTGED WNAVMYDGIM AYGGPSSSGM
760 770 780 790 800
IVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLNTAQK EEAEEKERKK
810 820 830 840 850
IARKESLENK KNNKPEVNQI ANSDNKVTID DYREEDEDKD PYPPCDVPVG
860 870 880 890 900
EEEEEEEEDE PEVPAGPRPR RISELNMKEK IAPIPEGSAF FILSKTNPIR
910 920 930 940 950
VGCHKLINHH IFTNLILVFI MLSSAALAAE DPIRSHSFRN TILGYFDYAF
960 970 980 990 1000
TAIFTVEILL KMTTFGAFLH KGAFCRNYFN LLDMLVVGVS LVSFGIQSSA
1010 1020 1030 1040 1050
ISVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIMIVTTLLQ
1060 1070 1080 1090 1100
FMFACIGVQL FKGKFYRCTD EAKSNPEECR GLFILYKDGD VDSPVVRERI
1110 1120 1130 1140 1150
WQNSDFNFDN VLSAMMALFT VSTFEGWPAL LYKAIDSNGE NIGPIYNHRV
1160 1170 1180 1190 1200
EISIFFIIYI IIVAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV
1210 1220 1230 1240 1250
EYALKARPLR RYIPKNPYQY KFWYVVNSSP FEYMMFVLIM LNTLCLAMQH
1260 1270 1280 1290 1300
YEQSKMFNDA MDILNMVFTG VFTVEMVLKV IAFKPKGYFS DAWNTFDSLI
1310 1320 1330 1340 1350
VIGSIIDVAL SEADNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW
1360 1370 1380 1390 1400
TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT
1410 1420 1430 1440 1450
FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSNFAI
1460 1470 1480 1490 1500
VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE
1510 1520 1530 1540 1550
YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD
1560 1570 1580 1590 1600
GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ
1610 1620 1630 1640 1650
VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ
1660 1670 1680 1690 1700
AGLRTLHDIG PEIRRAISCD LQDDEPEETK REEEDDVFKR NGALLGNHVN
1710 1720 1730 1740 1750
HVNSDRRDSL QQTNTTHRPL HVQRPSIPPA SDTEKPLFPP AGNSVCHNHH
1760 1770 1780 1790 1800
NHNSIGKQVP TSTNVNLNNA NMSKAAHGKR PSIGNLEHVS ENGHHSSHKH
1810 1820 1830 1840 1850
DREPQRRSSV KRTRYYETYI RSDSGDEQLP TICREDPEIH GYFRDAHCLG
1860 1870 1880 1890 1900
EQEYFSSEEC YEDDSSPTWS RQNYGYYSRY PGRNVDFERP RGYHHPQGFL
1910 1920 1930 1940 1950
EDDDSPICYD SRRSPRRRLL PPTPASHRRS SFNFECLRRQ SSQEEVPSSP
1960 1970 1980 1990 2000
TFPHRTALPL HLMQQQIMAV AGLDSSKAQK YSPSHSTRSW ATPPATPPYR
2010 2020 2030 2040 2050
DWTPCYTPLI QVEQSEALDQ MNGSLPSLHR SSWYTDEPDI SYRTFTPASL
2060 2070 2080 2090 2100
TVPSSFRNKN SDKQRSADSL VEAVLISEGL GRYARDPKFV SATKHEIADA
2110 2120 2130 2140 2150
CDLTIDEMES AASTLLNGNV CPRANGDVGP LSHRQDYELQ DFGPGYSDEE
2160 2170
PDPGRDEEDL ADEMICITTL
Length:2,170
Mass (Da):246,189
Last modified:March 28, 2018 - v1
Checksum:i107ADFF48FDD00A9
GO

Genome annotation databases

EnsembliENSCANT00000000618; ENSCANP00000000179; ENSCANG00000000117

Similar proteinsi

Entry informationi

Entry nameiA0A2K5H750_COLAP
AccessioniPrimary (citable) accession number: A0A2K5H750
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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