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Protein

Argininosuccinate synthase

Gene

argG

Organism
bacterium HR38
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei84CitrullineUniRule annotation1
Binding sitei89CitrullineUniRule annotation1
Binding sitei114ATP; via amide nitrogenUniRule annotation1
Binding sitei116AspartateUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei120CitrullineUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei173CitrullineUniRule annotation1
Binding sitei182CitrullineUniRule annotation1
Binding sitei258CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 14ATPUniRule annotation9

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotationImported
ORF Names:HRbin38_00383Imported
Organismibacterium HR38Imported
Taxonomic identifieri2035433 [NCBI]
Taxonomic lineageiBacteria

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 2 hits.
3.90.1260.10. 2 hits.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR11587. PTHR11587. 1 hit.
PfamiView protein in Pfam
PF00764. Arginosuc_synth. 1 hit.
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiView protein in PROSITE
PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2H6ARJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVLAYSGG LDTSIILKWL KETYKAEVIA FTADIGQGEE VEEARQKALR
60 70 80 90 100
TGASKAIALD LREEFVRDFV FPMFRAGAVY EGYYLLGTSI ARPLIAKYLV
110 120 130 140 150
RIAEEEGAEA IAHGATGKGN DQVRFELTAY ALKPDIRVIA PWREWHFKGR
160 170 180 190 200
QEMMAYAEAH GIPVPVTQEK PYSMDANLLH ISYEGGVLED PWAEPPKGMF
210 220 230 240 250
RMTVDPEEAP DTPEYVEVAF ERGDPVAVNG ERLSPAALLQ RLNEIGGRHG
260 270 280 290 300
VGRVDLVENR FVGMKSRGVY ETPGGTLLYH ARRAVESLTL DREVLHQRDQ
310 320 330 340 350
LAPKYAELVY YGFWYAPERE ALQAYFDHVA QAVTGVARLK LYKGNVYVVG
360 370 380 390 400
RKAPKSLYQK DLVSFDELGG YDQKDAEGFI RINALRLRVR ALVEALPSGN

EGEGKGHGA
Length:409
Mass (Da):45,625
Last modified:February 28, 2018 - v1
Checksum:i7B0DFFFCC915997E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BEIO01000094 Genomic DNA. Translation: GBD40521.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2H6ARJ5_9BACT
AccessioniPrimary (citable) accession number: A0A2H6ARJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported