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Protein

Meso-diaminopimelate D-dehydrogenase

Gene

CYL77_13265

Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Meso-diaminopimelate D-dehydrogenase (ddh), Meso-diaminopimelate D-dehydrogenase (FM102_11500), Meso-diaminopimelate D-dehydrogenase (ddh), Meso-diaminopimelate D-dehydrogenase (CYL77_13265), Meso-diaminopimelate D-dehydrogenase (AUO95_02830), Meso-diaminopimelate D-dehydrogenase (CS176_2347)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00026.

Names & Taxonomyi

Protein namesi
Recommended name:
Meso-diaminopimelate D-dehydrogenaseUniRule annotation (EC:1.4.1.16UniRule annotation)
Short name:
DAPDHUniRule annotation
Short name:
Meso-DAP dehydrogenaseUniRule annotation
Gene namesi
ORF Names:CYL77_13265Imported
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)Imported
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 268DAPDH_CInterPro annotationAdd BLAST151

Sequence similaritiesi

Belongs to the diaminopimelate dehydrogenase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR032094. DAPDH_C.
IPR010190. Diaminopimelate_DH_Ddh.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF16654. DAPDH_C. 1 hit.
PIRSFiPIRSF025648. DDH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01921. DAP-DH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A2H5I2T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIRVAIVG YGNLGRSVEK LIAKQPDMDL VGIFSRRATL DTKTPVFDVA
60 70 80 90 100
DVDKHADDVD VLFLCMGSAT DIPEQAPKFA QFACTVDTYD NHRDIPRHRQ
110 120 130 140 150
VMNEAATAAG NVALVSTGWD PGMFSINRVY AAAVLAEHQQ HTFWGPGLSQ
160 170 180 190 200
GHSDALRRIP GVQKAVQYTL PSEDALEKAR RGEAGDLTGK QTHKRQCFVV
210 220 230 240 250
ADAADHERIE NDIRTMPDYF VGYEVEVNFI DEATFDSEHT GMPHGGHVIT
260 270 280 290 300
TGDTGGFNHT VEYILKLDRN PDFTASSQIA FGRAAHRMKQ QGQSGAFTVL
310 320
EVAPYLLSPE NLDDLIARDV
Length:320
Mass (Da):35,199
Last modified:February 28, 2018 - v1
Checksum:iD29D3EB6DFDA35DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025533 Genomic DNA. Translation: AUI02600.1.
RefSeqiWP_011015254.1. NZ_LOQS01000006.1.

Similar proteinsi

Entry informationi

Entry nameiA0A2H5I2T1_CORGT
AccessioniPrimary (citable) accession number: A0A2H5I2T1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)